Assessing the Outcome of Experimental Therapies in Multiple Sclerosis Patients

“Mini-mental state”

1975 • 82,784 citations

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

Handbook of clinical neurology

1986 • 1,951 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

International Classification of Impairments, Disabilities and Handicaps

1984 • 1,293 citations

International classification of impairments, disabilities, and handicaps

1980 • 1,209 citations

Intensive Immunosuppression in Progressive Multiple Sclerosis

1983 • 813 citations

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

1990 • 590 citations

Major differences in the dynamics of primary and secondary progressive multiple sclerosis

1991 • 473 citations

THE ROLE OF NMR IMAGING IN THE ASSESSMENT OF MULTIPLE SCLEROSIS AND ISOLATED NEUROLOGICAL LESIONS

1987 • 471 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

Loss of Suppressor T Cells in Active Multiple Sclerosis

1980 • 446 citations

Screening for Organic Mental Syndromes in the Medically III

1977 • 426 citations

Neuropsychology of multiple sclerosis: A critical review

1986 • 392 citations

On the evaluation of disability in multiple sclerosis

1961 • 328 citations

In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis

1985 • 307 citations

A New Scale for Evaluating Disability in Multiple Sclerosis

1955 • 291 citations

Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

1990 • 289 citations

Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study.

1990 • 285 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Proteins of the nervous system

1966 • 266 citations

Upper extremity function in multiple sclerosis: improving assessment sensitivity with box-and-block and nine-hole peg tests.

1988 • 264 citations

Radioimmunoassay of Myelin Basic Protein in Spinal Fluid

1976 • 259 citations

Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients

1989 • 251 citations

A neurologic rating scale (NRS) for use in multiple sclerosis

1984 • 245 citations

Cognitive Function in Patients With Multiple Sclerosis

1980 • 242 citations

Immunocytochemical observations on the distribution of myelin‐associated glycoprotein and myelin basic protein in multiple sclerosis lesions

1980 • 240 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

Inter‐ and intrarater scoring agreement using grades 1.0 to 3.5 of the Kurtzke Expanded Disability Status Scale (EDSS)

1992 • 208 citations

Heterogeneity of blood‐brain barrier changes in multiple sclerosis

1990 • 201 citations

Myelin encephalitogenic protein fragments in cerebrospinal fluid of persons with multiple sclerosis

1977 • 195 citations

Screening for Cognitive Impairment in Multiple Sclerosis

1990 • 187 citations

Multiple sclerosis

1988 • 186 citations

Proteins of the Nervous System

1971 • 180 citations

Correlation of neuropsychological and MRI findings in chronic/progressive multiple sclerosis

1988 • 179 citations

Quantification of neurologic deficit

1990 • 175 citations

PROTEOLYTIC ACTIVITY AND BASIC PROTEIN LOSS IN AND AROUND MULTIPLE SCLEROSIS PLAQUES: COMBINED BIOCHEMICAL AND EIISTOCHEMICAL OBSERVATIONS

1972 • 162 citations

Magnetic Resonance Imaging Correlates of Dementia in Multiple Sclerosis

1987 • 161 citations

A RADIOIMMUNOASSAY FOR MYELIN BASIC PROTEIN AND ITS USE FOR QUANTITATIVE MEASUREMENTS

1975 • 158 citations

Temporal Lobe Involvement in Multiple Sclerosis Patients With Psychiatric Disorders

1987 • 150 citations

Interrater Reliability in Assessing Functional Systems and Disability on the Kurtzke Scale in Multiple Sclerosis

1988 • 139 citations

Scales for rating impairment in multiple sclerosis

1988 • 135 citations

A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluid

1980 • 133 citations

Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders

1980 • 133 citations

Quantification of neurologic deficit

1989 • 117 citations

Serial study of gadolinium‐DTPA MRI enhancement in multiple sclerosis

1990 • 116 citations

Benign versus chronic progressive multiple sclerosis: Magnetic resonance imaging features

1989 • 115 citations

Leukoencephalopathy and Elevated Levels of Myelin Basic Protein in the Cerebrospinal Fluid of Patients with Acute Lymphoblastic Leukemia

1980 • 94 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid

1989 • 88 citations

Lymphocyte subpopulations in patients with multiple sclerosis.

1983 • 86 citations

Immunoregulatory T‐cells and lymphocytotoxic antibodies in active multiple sclerosis: Weekly analysis over a six‐month period

1983 • 84 citations

The lesion of multiple sclerosis

1989 • 84 citations

Chronic progressive multiple sclerosis: Serial magnetic resonance brain imaging over six months

1989 • 82 citations

The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D.

1979 • 82 citations

Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis

1989 • 80 citations

Quantitative Multiple Sclerosis Plaque Assessment With Magnetic Resonance Imaging

1990 • 78 citations

Systemic lymphoblastoid interferon therapy in chronic progressive multiple Sclerosis. I. Clinical and MRI evaluation

1990 • 77 citations

A Clinical and Laboratory Study of Benign Multiple Sclerosis

1986 • 77 citations

Tumor necrosis factor alpha (TNFα) and neurological diseases Failure in detecting TNFα in the cerebrospinal fluid from patients with multiple sclerosis, AIDS dementia complex, and brain tumours

1989 • 76 citations

Suppressor T‐lymphocytes in multiple sclerosis: Analysis of patients with acute relapsing and chronic progressive disease

1983 • 76 citations

Radioimmunoassay of human myelin basic protein in tissue extract, cerebrospinal fluid and serum and its clinical application to patients with head injury

1978 • 74 citations

Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis

1990 • 73 citations

Multiple sclerosis de novo CNS IgG synthesis

1980 • 71 citations

Magnetic Resonance Imaging in the Assessment of Disease Activity in Multiple Sclerosis

1988 • 64 citations

Molecular internalization of a region of myelin basic protein

1977 • 60 citations

Interleukin‐2 levels in serum and cerebrospinal fluid of multiple sclerosis patients

1988 • 60 citations

The Disability Status Scale for multiple sclerosis

1989 • 59 citations

Magnetic resonance imaging in the evaluation of treatment in multiple sclerosis

1988 • 56 citations

The neurological examination: advancements in its quantification.

1975 • 54 citations

Immunologic mechanisms in neurologic and psychiatric disease

1988 • 53 citations

Multiple sclerosis

1988 • 52 citations

ESTERASE, PEPTIDASE AND PROTEINASE ACTIVITIES OF HUMAN CEREBROSPINAL FLUID IN MULTIPLE SCLEROSIS

1968 • 51 citations

A correlation between cerebrospinal fluid mylein basic protein and anti–myelin basic protein in multiple sclerosis patients

1987 • 51 citations

Molecular features of immunoreactive myelin basic protein in cerebrospinal fluid of persons with multiple sclerosis

1980 • 49 citations

Evoked Potentials to Test a Treatment of Chronic Multiple Sclerosis

1987 • 49 citations

Elevated soluble interleukin‐2 receptor levels in patients with active multiple sclerosis

1990 • 48 citations

Increase in myelin basic protein in CSF after brain surgery

1980 • 47 citations

Lymphocyte function and the role of regulator cells in multiple Sclerosis

1978 • 45 citations

Immunologic mechanisms in neurologic and psychiatric disease

1990 • 44 citations

The presence of immunoreactive myelin basic protein peptide in urine of persons with multiple sclerosis

1987 • 44 citations

Soluble interleukin‐2 receptors in cerebrospinal fluid from individuals with various neurological disorders

1990 • 44 citations

Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases

1981 • 43 citations

A Working Protocol to Be Used as a Guideline for Trials in Multiple Sclerosis

1983 • 42 citations

Magnetic resonance imaging: serial observations in multiple sclerosis.

1984 • 41 citations

The significance of abnormal immune responses in patients with multiple sclerosis

1981 • 41 citations

Epitopes of immunoreactive myelin basic protein in human cerebrospinal fluid

1986 • 40 citations

Degradation of myelin basic protein by cerebrospinal fluid: Preservation of antigenic determinants under physiological conditions

1979 • 39 citations

Magnetic resonance imaging and clinical correlations in multiple sclerosis

1988 • 38 citations

Effect of Methylprednisolone on CSF IgG Parameters, Myelin Basic Protein and Anti-Myelin Basic Protein in Multiple Sclerosis Exacerbations

1986 • 37 citations

Levels in stroke patients of CSF astroprotein, an astrocyte-specific cerebroprotein.

1979 • 37 citations

Radioimmunoassay of serum myelin basic protein and its application to patients with cerebrovascular accident

1979 • 36 citations

Myelin basic protein in cerebrospinal fluid from children

1978 • 33 citations

Monoclonal idiotypic and anti-idiotypic antibodies produced by immunization with peptides specified by a region of human myelin basic protein mRNA and its complement

1989 • 33 citations

Handcuff neuropathies

1991 • 32 citations

NMR studies in experimental allergic encephalomyelitis (EAE): Normalization of T1 and T2 with parenchymal cellular infiltration

1986 • 30 citations

The relationship between levels of cerebrospinal fluid myelin basis protein and IgG measurements in patients with multiple sclerosis

1985 • 29 citations

The antigenic reactivity of small fragments derived from human myelin basic protein peptide 43-88.

1982 • 28 citations

Radioimmunoassay of myelin basic protein in cerebrospinal fluid and its clinical application to patients with neurological diseases

1980 • 28 citations

Serum degradation of myelin basic protein with loss of encephalitogenic activity: Evidence for an enzymatic process

1978 • 26 citations

Neuroepidemiology. Part II: Assessment of therapeutic trials

1986 • 26 citations

Serial Pattern Shift Visual Evoked Potentials in Multiple Sclerosis

1984 • 26 citations

Activity of 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase in human cerebrospinal fluid

1979 • 25 citations

Proteinases in inflammatory demyelinating disease

1985 • 25 citations

Human myelin basic protein peptide 69–89: Immunochemical features and use in immunoassays of cerebrospinal fluid

1988 • 25 citations

A derivative of myelin‐associated glycoprotein in cerebrospinal fluid of normal subjects and patients with neurological disease

1985 • 25 citations

The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis.

1988 • 24 citations

Serial Recordings of Multimodality Evoked Potentials in Multiple Sclerosis: A Four Year Follow-Up Study

1986 • 24 citations

Proteinase inhibitors in cerebrospinal fluid in multiple sclerosis

1979 • 23 citations

Metabolism of a peptide of human myeh basic protein in the rabbit

1980 • 22 citations

Cerebrospinal fluid levels of immunoreactive substance P and somatostatin in patients with multiple sclerosis and inflammatory CNS disease

1990 • 21 citations

CEREBROSPINAL FLUID CHOLESTEROLS AND PHOSPHOLIPIDS IN MULTIPLE SCLEROSIS

2009 • 20 citations

Neurobehavioural Aspects of Multiple Sclerosis

1992 • 20 citations

Conformational Correlates of the Epitopes of Human Myelin Basic Protein Peptide 80–89

1990 • 19 citations

Akinetic mutism caused by bilateral anterior cerebral tuberculous obliterative arteritis

1990 • 17 citations

Immunoreactive IFN-gamma in CSF in neurological disorders.

1987 • 17 citations

Variability of central conduction in the course of multiplesclerosis

1987 • 16 citations

Cerebrospinal fluid levels of myelin basic protein-like material and soluble interleukin-2 receptor in multiple sclerosis

1991 • 16 citations

Molecular size of myelin basic protein immunoactivity in spinal fluid

1984 • 16 citations

Multiple sclerosis: immunopathologic mechanisms in the progression and resolution of inflammatory demyelination.

1990 • 15 citations

Quantitative methods in assessment of neurologic function.

1981 • 14 citations

Reply

1990 • 13 citations

Inhibition by Serum of Encephalitogenic Activity of Myelin Basic Protein

1975 • 13 citations

Experimental allergic encephalomyelitis in the monkey: humoral immunity and blood-brain barrier function

1989 • 11 citations

Three possible laboratory indexes of disease activity in multiple sclerosis

1987 • 11 citations

Magnetic resonance imaging and degree of disability in multiple sclerosis.

1988 • 11 citations

The degradation of human myelin basic protein peptide 43–88 by human renal neutral proteinase

1983 • 10 citations

Diagnostic and therapeutic trials in multiple sclerosis

1989 • 10 citations

2′, 3′‐cyclic nucleotide 3′ ‐phosphodiesterase in cerebrospinal fluid

1981 • 10 citations

T-cell subsets in multiple sclerosis: Lack of correlation between helper and suppressor T cells and the clinical state

1985 • 9 citations

Deleted Work

1955 • 0 citations