Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

The aggregation of blood platelets

1963 • 2,125 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

A new solid-state reagent to iodinate proteins

1982 • 893 citations

Cytoplasmic free Ca²⁺ in human platelets: Ca²⁺ thresholds and Ca‐independent activation for shape‐change and secretion

1982 • 537 citations

Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN)

1981 • 374 citations

Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

1977 • 274 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)

1989 • 216 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

Calcium-dependent proteolysis occurs during platelet aggregation.

1983 • 185 citations

Calpain II Involvement in Mitosis

1988 • 163 citations

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

1988 • 139 citations

Cysteinyl Proteinases and Their Selective Inactivation

1990 • 136 citations

Brain spectrin, calpain and long-term changes in synaptic efficacy

1987 • 136 citations

Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules

1988 • 130 citations

Molecular cloning of the cDNA for the large subunit of the high-calcium-requiring form of human calcium-activated neutral protease

1988 • 129 citations

Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activation

1987 • 123 citations

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

1980 • 120 citations

Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease.

1986 • 113 citations

Calpain inhibition by peptide epoxides

1985 • 106 citations

Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d

1989 • 105 citations

The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor

1989 • 86 citations

Synergism of platelet-aggregating agents. Role of elevation of cytoplasmic calcium.

1987 • 79 citations

The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases

1980 • 75 citations

Ionomycin can elevate intraplatelet Ca2+ and activate phospholipase a without activating phospholipase C

1984 • 72 citations

Demonstration of a relationship between talin and P235, a major substrate of the calcium‐dependent protease in platelets

1986 • 68 citations

Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry?

1987 • 66 citations

Active center differences between cathepsins L and B: The S₁ binding region

1988 • 66 citations

Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibody

1984 • 60 citations

Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain

1989 • 47 citations

Calcium-dependent proteins in platelets response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agents

1980 • 47 citations

The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B

1987 • 46 citations

Shape change and uptake of 5-hydroxytryptamine in human blood platelets: Action of neuropsychotropic drugs

1979 • 46 citations

Gene organization of the small subunit of human calcium-activated neutral protease

1986 • 42 citations

Montreal platelet syndrome: a defect in calcium-activated neutral proteinase (calpain)

1989 • 40 citations

Platelet‐derived growth factor‐induced alterations in vinculin distribution in porcine vascular smooth muscle cells

1987 • 37 citations

The effects of autolysis on the structure of chicken calpain II

1987 • 35 citations

The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents

1989 • 33 citations

Synthesis and properties of peptidyl derivatives of arginylfluoromethanes

1988 • 31 citations

Probing of the structural stability of vimentin and desmin-type intermediate filaments with Ca2+-activated proteinase, thrombin and lysine-specific endoproteinase Lys-C.

1987 • 31 citations

Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movement

1988 • 30 citations

Degradation of Myocardial Structural Proteins in Myocardial Infarcted Dogs is Reduced by Ep459, a Cysteine Proteinase Inhibitor

1986 • 25 citations

Heterogeneity in late-onset metachromatic leukodystrophy. Effect of inhibitors of cysteine proteinases.

1986 • 19 citations

The thiol proteinase inhibitors, Z-Phe-PheCHN2 and Z-Phe-AlaCHN2, inhibit lysosomal protein degradation in isolated rat hepatocytes

1983 • 18 citations

Calpain I activation is not correlated with aggregation in human platelets

1989 • 18 citations

Collagen-stimulated human platelet aggregation is mediated by endogenous calcium-activated neutral protease.

1989 • 16 citations

Thiolprotease inhibitor, EST, can inhibit thrombin-induced platelet activation

1990 • 15 citations

Elucidation of calpain dependent phosphorylation of myosin light chain in human platelets.

1987 • 15 citations

Influence of a calcium dependent protease inhibitor on platelet activation and secretion

1987 • 14 citations

Synthetic fluoropeptides as pharmacologically useful compounds.

1988 • 5 citations