Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry?

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

The role of phospholipids and factor Va in the prothrombinase complex.

1980 • 672 citations

Changes in membrane phospholipid distribution during platelet activation

1983 • 551 citations

Cytoplasmic free Ca²⁺ in human platelets: Ca²⁺ thresholds and Ca‐independent activation for shape‐change and secretion

1982 • 537 citations

International Encyclopedia of Pharmacology and Therapeutics

1972 • 497 citations

Generation of Prothrombin‐Converting Activity and the Exposure of Phosphatidylserine at the Outer Surface of Platelets

1982 • 472 citations

Book Review: International Encyclopedia of Pharmacology and Therapeutics

1967 • 313 citations

Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear.

1982 • 310 citations

Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

1977 • 274 citations

Incorporation and translocation of aminophospholipids in human erythrocytes

1985 • 264 citations

The role of activated human platelets in prothrombin and factor X activation

1985 • 240 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

Interactions between membrane skeleton proteins and the intrinsic domain of the erythrocyte membrane

1982 • 235 citations

Outside-inside translocation of aminophospholipids in the human erythrocyte membrane is mediated by a specific enzyme

1986 • 224 citations

Calcium-dependent proteolysis occurs during platelet aggregation.

1983 • 185 citations

Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells.

1985 • 182 citations

On the association of glycoprotein Ib and actin-binding protein in human platelets.

1985 • 165 citations

Involvement of spectrin in the maintenance of phase-state asymmetry in the erythrocyte membrane

1982 • 159 citations

ATP‐dependent translocation of amino phospholipids across the human erythrocyte membrane

1986 • 157 citations

Thrombin and ionomycin can raise platelet cytosolic Ca2+ to micromolar levels by discharge of internal Ca2+ stores: Studies using fura-2

1986 • 149 citations

Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion

1984 • 147 citations

Isolation of calcium-dependent platelet proteins that interact with actin

1981 • 128 citations

An analysis of the mechanism of local anesthetic inhibition of platelet aggregation and secretion.

1976 • 128 citations

Spectrin-phospholipid interaction

1980 • 124 citations

Identification of talin as a major cytoplasmic protein implicated in platelet activation

1985 • 121 citations

Purification and characterization of a calcium dependent sulfhydryl protease from human platelets

1981 • 118 citations

Local anesthetics, chlorpromazine and propranolol inhibit stimulus-activation of phospholipase A2 in human platelets.

1979 • 113 citations

Modulation of membrane structure by Ca2+ and dibucaine as detected by 31P NMR

1979 • 112 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: Differential inhibition by PGE1, local anesthetics and a serine-protease inhibitor

1977 • 104 citations

Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

1986 • 101 citations

Purification of human platelet calcium-activated protease. Effect on platelet and endothelial function.

1983 • 95 citations

Topology of amino‐phospholipids in the red cell membrane

1978 • 88 citations

Measurement of ionized calcium in blood platelets with a new generation calcium indicator

1985 • 72 citations

Cross-linking of SH-groups in the erythrocyte membrane enhances transbilayer reorientation of phospholipids. Evidence for a limited access of phospholipids to the reorientation sites

1984 • 69 citations

The filamins: properties and functions

1985 • 69 citations

Ultrastructural studies of the interaction of spectrin with phosphatidylserine liposomes

1986 • 69 citations

Demonstration of a relationship between talin and P235, a major substrate of the calcium‐dependent protease in platelets

1986 • 68 citations

The involvement of cytoskeleton in the regulation of transbilayer movement of phospholipids in human blood platelets

1985 • 67 citations

Red cell membrane abnormalities in chronic myeloid leukaemia

1983 • 62 citations

Stabilizing factors of phospholipid asymmetry in the erythrocyte membrane

1984 • 60 citations

Cleavage of cytoskeletal proteins by two forms of Ca2+ activated neutral proteases in human platelets

1982 • 58 citations

Activation of cellular protein kinase C and mode of inhibitory action of phospholipid-interacting compounds

1985 • 56 citations

Ultrastructural studies of the interaction of spectrin with phosphatidylserine liposomes

1986 • 54 citations

Ca²⁺‐dependent association between a Ca²⁺‐activated neutral proteinase (CaANP) and its specific inhibitor

1981 • 54 citations

Bacterial cytotoxins, amphotericin B and local anesthetics enhance transbilayer mobility of phospholipids in erythrocyte membranes. Consequences for phospholipid asymmetry

1986 • 52 citations

Platelet prothrombin converting activity in hereditary disorders of platelet function

1986 • 51 citations

Hydrolytic and Autolytic Behavior of Two Forms of Calcium-Activated Neutral Protease (CANP)

1985 • 49 citations

Calcium-dependent proteins in platelets response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agents

1980 • 47 citations

The Nature of the Binding Site for Prothrombinase at the Platelet Surface as Revealed by Lipolytic Enzymes

1982 • 45 citations

Effects of local anesthetics on human platelets: filopodial suppression and endogenous proteolysis

1979 • 45 citations

Effects of tertiary amine local anesthetics on von Willebrand factor- dependent platelet function: alteration of membrane reactivity and degradation of GPIb by a calcium-dependent protease(s)

1982 • 43 citations

Human platelet activation in the absence of aggregation: a calcium- dependent phenomenon independent of thromboxane formation

1982 • 42 citations

A 2H-NMR study on the interactions of the local anesthetic tetracaine with membranes containing phosphatidylserine

1986 • 41 citations

Intracellular calcium storage and release in the human platelet. Chlorotetracycline as a continuous monitor.

1984 • 40 citations

Development of Procoagulant Binding Sites on the Platelet Surface

1985 • 35 citations

Two forms of Ca++-activated neutral protease in platelets

1981 • 32 citations

The structural organization of skeletal proteins influences lipid translocation across erythrocyte membrane.

1985 • 31 citations

Activity of Human Blood Platelets in Prothrombin and in Factor X Activation Induced by Ionophore A23187

1983 • 31 citations

Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents II. Effects of different inhibitors

1978 • 30 citations

Phospholipid asymmetry in the membranes of intact human erythrocytes and in spectrin-free microvesicles derived from them

1984 • 29 citations

Platelet membrane alterations induced by the local anesthetic dibucaine

1986 • 23 citations

Measurement of Thromboxane A2 Elevation of Ionized Calcium in Collagen-Stimulated Platelets with the Photoprotein, Aequorin

1986 • 21 citations

Disruption of phospholipid asymmetry in erythrocyte vesicles deficient in spectrin

1985 • 20 citations

Effects of diamide and dibucaine on platelet glycoprotein Ib, actin-binding protein and cytoskeleton

1985 • 20 citations

The Effect of Local Anaesthetics and Antiarrhythmic Agents on the Responses of Rabbit Platelets to ADP and Thrombin

1981 • 19 citations

Regulation of Mammalian Cytosolic Ca2+-Requiring Neutral Proteinases

1985 • 17 citations

Lipids of the platelet membrane.

1986 • 15 citations

Differential effects of local anesthetics and propranolol on arachidonic acid and adenosine 5′-diphosphate-induced aggregation in rabbit platelets

1980 • 14 citations

Interrelationship between secretion, protein phosphorylation and intracellular Ca2+ concentration in platelets stimulated by thrombin or thromboxane A2 analogue

1986 • 14 citations

The effect of verapamil, lanthanum and local anesthetics on serotonin release from rabbit platelets

1982 • 12 citations

Characterization of the ATPase activities of myosins isolated from the membrane and the cytoplasmic fractions of human platelets

1984 • 12 citations

The proteolytic system involving calpains

1985 • 10 citations

The Inhibition of Platelet Prothrombinase Activity by Prostacyclin

1984 • 7 citations

Measurement of Intracellular Platelet Calcium with Aequorin and Quin 2

1985 • 4 citations