Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy.

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 • 1,702 citations

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials

1998 • 1,090 citations

Adjuvant Cyclophosphamide, Methotrexate, and Fluorouracil in Node-Positive Breast Cancer — The Results of 20 Years of Follow-up

1995 • 1,027 citations

Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence

1999 • 933 citations

Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies

1994 • 717 citations

The metabolism of homocysteine: pathways and regulation

1998 • 583 citations

The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

1992 • 562 citations

Disorders of propionate and methylmalonate metabolism

1982 • 531 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study

1999 • 443 citations

The Metabolic Basis of Inherited Disease.

1991 • 409 citations

Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations

1995 • 296 citations

Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency

1993 • 265 citations

Cobalamin, the stomach, and aging

1997 • 226 citations

Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial.

1991 • 222 citations

Pemetrexed Disodium: A Novel Antifolate Clinically Active Against Multiple Solid Tumors

2001 • 205 citations

There are no bad anticancer agents, only bad clinical trial designs--twenty-first Richard and Hinda Rosenthal Foundation Award Lecture.

1998 • 185 citations

Folate-based thymidylate synthase inhibitors as anticancer drugs

1995 • 157 citations

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

1998 • 142 citations

Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency

1993 • 127 citations

A prospective randomized trial of methotrexate versus cisplatin in the treatment of recurrent squamous cell carcinoma of the head and neck

1983 • 120 citations

Can Dietary Supplements with Folic Acid or Vitamin B6 Reduce Cardiovascular Risk? Design of Clinical Trials to Test the Homocysteine Hypothesis of Vascular Disease

1998 • 102 citations

A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid

1996 • 53 citations

Folate–Homocysteine Interrelations: Potential New Markers of Folate Status

1999 • 26 citations