Pathophysiology of cancer-related anemia

Anemia of Chronic Disease

2005 • 3,522 citations

Chemotherapy-Induced Anemia in Adults: Incidence and Treatment

1999 • 918 citations

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1979 • 907 citations

Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency

1997 • 869 citations

Erythropoietin

1991 • 852 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Decreased Erythropoietin Response in Patients with the Anemia of Cancer

1990 • 680 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 612 citations

Effect of inflammatory cytokines on hypoxia-induced erythropoietin production

1992 • 518 citations

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.

1986 • 492 citations

CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

1988 • 490 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 475 citations

Erythropoietin Treatment of Anemia Associated with Multiple Myeloma

1990 • 459 citations

21-TRISOMY/NORMAL MOSAICISM IN AN INTELLIGENT CHILD WITH SOME MONGOLOID CHARACTERS

1963 • 438 citations

Phase I study of recombinant tumor necrosis factor in cancer patients.

1987 • 430 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Anemia of Chronic Disorders

1984 • 419 citations

GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression

1999 • 364 citations

Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2

1996 • 348 citations

The molecular mechanism of erythropoietin action

1992 • 274 citations

Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis

1999 • 262 citations

Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis

1988 • 257 citations

Serum Immunoreactive Erythropoietin in HIV-Infected Patients

1989 • 236 citations

Cachectin/tumor necrosis factor‐α alters red blood cell kinetics and induces anemia in vivo

1989 • 230 citations

Blunted erythropoietin response to anaemia in rheumatoid arthritis

1987 • 221 citations

Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys

1992 • 209 citations

Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

1999 • 206 citations

Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor.

1989 • 195 citations

Pathogenesis of the anemia of chronic disease: A cytokine‐mediated anemia

1995 • 194 citations

Prediction of response to erythropoietin treatment in chronic anemia of cancer [see comments]

1994 • 194 citations

Regulation of iron metabolism in the acute‐phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

1998 • 178 citations

Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice

1989 • 171 citations

Large-scale UK audit of blood transfusion requirements and anaemia in patients receiving cytotoxic chemotherapy

2000 • 163 citations

Cisplatin-associated anemia: an erythropoietin deficiency syndrome.

1995 • 158 citations

Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin [see comments]

1991 • 158 citations

Tumor necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells.

1987 • 155 citations

Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?

1999 • 154 citations

Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.

1993 • 150 citations

Inhibition of human erythroid colony‐forming units by interleukin‐1 is mediated by gamma interferon

1992 • 147 citations

Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.

1993 • 145 citations

The anemia of chronic disease: Spectrum of associated diseases in a series of unselected hospitalized patients

1989 • 144 citations

In vivo hematopoietic effects of recombinant interleukin-1 alpha in mice: stimulation of granulocytic, monocytic, megakaryocytic, and early erythroid progenitors, suppression of late-stage erythropoiesis, and reversal of erythroid suppression with erythropoietin

1989 • 141 citations

Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias

1987 • 140 citations

Radioimmunoassay of tumor necrosis factor in serum.

1987 • 138 citations

Prediction of response to erythropoietin treatment in chronic anemia of cancer [see comments]

1994 • 131 citations

Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease

1971 • 129 citations

Subcutaneous erythropoietin for treatment of refractory anemia in hematologic disorders. Results of a phase I/II clinical trial [see comments]

1992 • 127 citations

Regulation of Cellular Iron Metabolism by Erythropoietin: Activation of Iron-Regulatory Protein and Upregulation of Transferrin Receptor Expression in Erythroid Cells

1997 • 125 citations

Role of Cytokines in the Pathogenesis of Anemia of Chronic Disease in Rheumatoid Arthritis

1999 • 111 citations

In vivo suppression of erythropoiesis by tumor necrosis factor-alpha (TNF-alpha): reversal with exogenous erythropoietin (EPO).

1990 • 111 citations

Bone Marrow Erythropoiesis in the Anemia of Infection, Inflammation, and Malignancy

1974 • 107 citations

The Frequency of Red Cell Transfusion for Anemia in Patients Receiving Chemotherapy A Retrospective Cohort Study

1993 • 106 citations

Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection

1993 • 102 citations

Erythropoiesis in multiple myeloma: defective red cell production due to inappropriate erythropoietin production

1992 • 101 citations

Serum erythropoietin levels in patients receiving intensive chemotherapy and radiotherapy

1990 • 100 citations

Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro.

1988 • 99 citations

Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix.

1986 • 98 citations

In vivo hematopoietic effects of recombinant interleukin-1 alpha in mice: stimulation of granulocytic, monocytic, megakaryocytic, and early erythroid progenitors, suppression of late-stage erythropoiesis, and reversal of erythroid suppression with erythropoietin

1989 • 97 citations

STUDIES OF THE ANEMIA AND IRON METABOLISM IN CANCER 1

1956 • 96 citations

Anemia of chronic disorders in systemic autoimmune diseases.

1997 • 96 citations

Increased plasma viscosity as a reason for inappropriate erythropoietin formation.

1993 • 95 citations

Circulating erythropoietin in patients with myelodysplastic syndromes

1989 • 94 citations

Red Blood Cell Precursor Mass as an Independent Determinant of Serum Erythropoietin Level

1998 • 89 citations

Clinical significance of neopterin for prognosis and follow-up in ovarian cancer.

1987 • 89 citations

Interferon γ Downregulates Stem Cell Factor and Erythropoietin Receptors But Not Insulin-Like Growth Factor-I Receptors in Human Erythroid Colony-Forming Cells

1997 • 85 citations

Radiotherapy-Associated Anemia: The Scope of the Problem

2000 • 82 citations

Predictive value of interleukin-6 and neopterin in patients with multiple myeloma.

1991 • 81 citations

Subunit dimers in sheep spleen apoferritin. The effect on iron storage.

1983 • 78 citations

Correlation between neopterin, interferon‐gamma and haemoglobin in patients with haematological disorders

1990 • 77 citations

Anemia in Children With Cancer Is Associated With Decreased Erythropoietic Activity and Not With Inadequate Erythropoietin Production

1998 • 70 citations

Mechanisms of abnormal erythropoiesis in malignancy

1983 • 70 citations

Reutilization of iron in anemia complicating malignant neoplasma.

1963 • 70 citations

Red Blood Cell Precursor Mass as an Independent Determinant of Serum Erythropoietin Level

1998 • 65 citations

Neopterin and prognosis in patients with adenocarcinoma of the colon.

1993 • 63 citations

Studies on the Anemia of Disseminated Malignant Neoplastic Disease. II. Study of the Life Span of the Erythrocyte

1956 • 61 citations

The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake

1994 • 60 citations

Inadequate Erythropoietin Response to Anaemia in HIV Patients: Relationship to Serum Levels of Tumour Necrosis Factor‐Alpha, Interleukin‐6 and Their Soluble receptors

1997 • 58 citations

Subcutaneous erythropoietin for treatment of refractory anemia in hematologic disorders [letter; comment]

1992 • 53 citations

Reutilization of Iron in Anemia Complicating Malignant Neoplasms

1963 • 50 citations

In vitro studies of erythropoietin-dependent regulation of erythropoiesis in myelodysplastic syndromes.

1990 • 49 citations

A Retrospective Review of Blood Transfusions in Cancer Patients with Anemia

1999 • 49 citations

Tumor necrosis factor exerts dose-dependent effects on erythropoiesis and myelopoiesis in vivo.

1990 • 48 citations

In vivo hematopoietic effects of tumor necrosis factor-alpha in normal and erythroleukemic mice: characterization and therapeutic applications

1988 • 48 citations

Mechanisms of erythroid suppression in the anemia of chronic disease.

1987 • 48 citations

Activation of Hematopoietic Progenitor Kinase-1 by Erythropoietin

1999 • 45 citations

Macrophage control of normal and leukemic erythropoiesis: identification of the macrophage-derived erythroid suppressing activity as interleukin-1 and the mediator of its in vivo action as tumor necrosis factor

1990 • 43 citations

Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures

1993 • 40 citations

Anemia in malignant neoplastic disease

1963 • 39 citations

Inhibition of erythropoietin production in vitro by human interferon gamma

1994 • 38 citations

Anaemia of lung cancer is due to impaired erythroid marrow response to erythropoietin stimulation as well as relative inadequacy of erythropoietin production

1997 • 35 citations

Anemia in Cancer

1985 • 35 citations

Serum erythropoietin and erythropoiesis in patients with myelodysplastic syndromes

1990 • 35 citations

Serum erythropoietin level in anemic cancer patients

2000 • 34 citations

The role of interleukin 1, erythropoietin and red cell bound immunoglobulins in the anaemia of rheumatoid arthritis.

1991 • 34 citations

Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.

1992 • 33 citations

Neopterin as a prognostic parameter in patients with squamous-cell carcinomas of the oral cavity

1998 • 30 citations

Haematologic effects of TNF

1993 • 30 citations

Iron stores and serum transferrin receptor levels during recombinant human erythropoietin treatment of anemia in rheumatoid arthritis

1992 • 29 citations

Serum erythropoietin concentrations in patients with myelodysplastic syndromes

1991 • 29 citations

Decreased affinity and number of transferrin receptors on erythroblasts in the anemia of rheumatoid arthritis

1993 • 26 citations

Erythropoietin prevents chemotherapy-induced anemia: Case report

1990 • 25 citations

Erythropoietic effect of plasma from patients with advanced cancer.

1971 • 25 citations

Reduced erythropoitein levels as a cause of anaemia in patients with lung cancer

1986 • 24 citations

Serum erythropoietin in chronic lymphocytic leukaemia

1996 • 23 citations

Anemia-inducing substance from plasma of patients with advanced malignant neoplasms.

1995 • 22 citations

Effects of neopterin and 7,8‐dihydroneopterin on hypoxia‐induced renal erythropoietin production

1999 • 21 citations

An epidemiological review of red cell transfusions in cancer chemotherapy.

1999 • 21 citations

A Phase II combination trial with recombinant human tumor necrosis factor and gamma interferon in patients with colorectal cancer

1991 • 21 citations

879 An epidemiological review of anaemia in cancer chemotherapy in Canada

1995 • 20 citations

Serum erythropoietin titers in hematological malignancies and related diseases

1992 • 20 citations

Testosterone, erythropoietin and anaemia in patients with disseminated bronchial cancer

1984 • 19 citations

Fas Antigen (CD95) in pure erythroid cell line AS-E2 is induced by interferon-γ and tumor necrosis factor-α and potentiates apoptotic death

1999 • 19 citations

The secretory erythropoietin response in patients with multiple myeloma and Waldenstrom's macroglobulinaemia

1990 • 18 citations

Specific binding of interferon-gamma to high affinity receptors on human erythroid colony-forming cells.

1997 • 16 citations

Serum neopterin levels in haematological malignancies.

1993 • 13 citations

Preliminary results of amifostine administration in combination with recombinant human erythropoietin in patients with myelodysplastic syndromes.

2001 • 11 citations

Erythropoietin response in anaemic patients with multiple myeloma and other lymphoid malignancies infiltrating the bone marrow

1992 • 11 citations

Inhibition of Erythropoietin Production by Cytokines and Chemotherapy May Contribute to the Anemia in Malignant Diseases

1994 • 10 citations

Serum erythropoietin increase in patients receiving adjuvant therapy with 5-fluorouracil and leucovorin.

1994 • 10 citations

The secretory erythropoietin response in patients with multiple myeloma and Waldenstrom's macroglobulinaemia

1990 • 10 citations

Elimination of anemia-inducing substance by cyclic plasma perfusion of tumor-bearing rabbits.

1999 • 10 citations

Phase II Trial of Recombinant DNA ?? -Interferon in Advanced Colorectal Cancer: A Southwest Oncology Group Study

1991 • 9 citations

Serum erythropoietin levels in patients with solid tumours

1994 • 8 citations

Circulating Erythropoietin Levels in Pathophysiological Conditions^a

1994 • 3 citations

Inappropriate Increase in Plasma Erythropoietin Levels Following PEB Chemotherapy

1992 • 2 citations

Erythropoietin stimulates serine kinase activity in erythropoietin-dependent cells.

1994 • 2 citations