Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release

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Inhibition of islet nitric oxide synthase increases arginine-induced insulin release

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Inhibition of Nitric Oxide Synthesis Enhances the Expression of Inducible Nitric Oxide Synthase mRNA and Protein in a Model of Chronic Liver Inflammation

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Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production

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Cytokines, nitric oxide and insulin secreting cells.

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Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3′ : 5′-cyclic monophosphate and adenosine 3′ : 5′-cyclic monophosphate concentrations

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Protective action by hemin against interleukin-1β induced inhibition of rat pancreatic islet function

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Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats*

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