A NOVEL APPROACH FOR LOCALIZATION OF THE CONTINUOUS PROTEIN ANTIGENIC SITES BY COMPREHENSIVE SYNTHETIC SURFACE SCANNING: ANTIBODY AND T-CELL ACTIVITY TO SEVERAL INFLUENZA HEMAGGLUTININ SYNTHETIC SITES

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

1981 • 1,603 citations

Hydrolysis of Proteins with p-Toluenesulfonic Acid

1971 • 1,052 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Immunogenic structure of the influenza virus hemagglutinin

1982 • 759 citations

Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins

1975 • 474 citations

Tapping the immunological repertoire to produce antibodies of predetermined specificity

1982 • 473 citations

Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice.

1977 • 361 citations

Precise determination of the entire antigenic structure of lysozyme: Molecular features of protein antigenic structures and potential of ‘surface-simulation’ synthesis—a powerful new concept for protein binding sites

1978 • 246 citations

Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75

1980 • 243 citations

Antibodies That React with Predetermined Sites on Proteins

1983 • 221 citations

Studies on the origin of pandemic influenza

1973 • 210 citations

Immunochemistry of sperm whale myoglobin. I. Specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen

1968 • 200 citations

Antibodies of Predetermined Specificity in Biology and Medicine

1984 • 194 citations

Lymphocyte Specificity to Protein Antigens

1977 • 175 citations

Anti-influenza response achieved by immunization with a synthetic conjugate.

1982 • 172 citations

A proposal for the nomenclature of antigenic sites in peptides and proteins

1978 • 166 citations

Amino Acid Substitution and the Antigenicity of Globular Proteins

1975 • 163 citations

Preparation and properties of an artificial antigen immunologically related to tobacco mosaic virus

1963 • 125 citations

ANTIBODIES TO A UNIQUE REGION IN LYSOZYME PROVOKED BY A SYNTHETIC ANTIGEN CONJUGATE

1969 • 124 citations

Genetic control of immune response to sperm whale myoglobin in mice. II. T lymphocyte proliferative response to the synthetic antigenic sites.

1979 • 121 citations

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the α-chain of human haemoglobin

1980 • 114 citations

Immunochemistry of sperm-whale myoglobin

1973 • 109 citations

Immunochemistry of sperm-whale myoglobin—XVI: Accurate delineation of the single region in sequence 1–55 by immunochemical studies of synthetic peptides. Some conclusions concerining antigenic structures of proteins

1974 • 104 citations

Topographic determinants on cytochrome c. I. The complete antigenic structures of rabbit, mouse, and guanaco cytochromes c in rabbits and mice1.

1977 • 100 citations

Genetic Control of Immune Response to Sperm Whale Myoglobin in Mice

1979 • 99 citations

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites

1980 • 96 citations

Properties of different artificial antigens immunologically related to tobacco mosaic virus

1965 • 92 citations

Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control.

1978 • 86 citations

Immunity and protection against influenza virus by synthetic peptide corresponding to antigenic sites of hemagglutinin.

1984 • 85 citations

Structurally inherent antigenic sites. Localization of the antigenic sites of the α-chain of human haemoglobin in three host species by a comprehensive synthetic approach

1982 • 81 citations

Immunochemistry of Proteins

1977 • 78 citations

Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin.

1983 • 69 citations

Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by ‘surface simulation’ synthesis

1977 • 69 citations

Topographic Determinants on Cytochrome c

1977 • 66 citations

Immunochemistry of sperm-whale myoglobin

1974 • 66 citations

The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species

1980 • 65 citations

Genetic control of the immune response to myoglobin. IV. Mouse antibodies in outbred and congenic strains against sperm-whale myoglobin recognize the same antigenic sites that are recognized by antibodies raised in other species

1981 • 63 citations

Delineation of the third antigenic site of lysozyme by application of a novel ‘surface-simulation’ synthetic approach directly linking the conformationally adjacent residues forming the site

1976 • 63 citations

Genetic Control of Immune Response to Sperm Whale Myoglobin in Mice

1978 • 61 citations

Molecular Localization of the Full Profile of the Continuous Regions Recognized by Myoglobin Primed T-Cells Using Synthetic Overlapping Peptides Encompassing the Entire Molecule

1983 • 56 citations

Localization and verification by synthesis of five antigenic sites of bovine serum albumin

1979 • 52 citations

Antigenic Determinants of Proteins of Defined Sequences

1972 • 50 citations

Production of Monoclonal Antibodies to Surface Regions that are Non-Immunogenic in a Protein Using Free Synthetic Peptide as Immunogens: Demonstration with Sperm-Whale Myoglobin

1983 • 45 citations

Antibodies to Sperm-Whale Myoglobin Evoked by Free Synthetic Peptides of an Antigenic Site

1982 • 44 citations

Immune recognition of serum albumin—XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin

1981 • 42 citations

Production of monoclonal antibodies with preselected submolecular binding specificities to protein antigenic sites: Antibodies to sperm whale myoglobin sites

1983 • 39 citations

Enzymic and immunochemical properties of lysozyme

1977 • 39 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN*

1979 • 39 citations

The specificity of antibodies to a peptide determinant of the tobacco mosaic virus protein induced by immunization with the peptide conjugate

1971 • 38 citations

The Antigenic Structure of Hen Egg-White Lysozyme: A Model for Disulfide-Containing Proteins

1977 • 37 citations

Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal Autoreactivity in rabbits of antibodies to spermwhale myoglobin

1977 • 34 citations

Production of monoclonal antibodies with pre-selected submolecular binding specificities to protein determinants: Demonstration with sperm whale myoglobin

1982 • 32 citations

Immunochemistry of the Tobacco Mosaic Virus Protein

1977 • 30 citations

Genetic control of the immune response to myoglobin. VI. Inter-site influences in T-lymphocyte proliferative response from analysis of cross-reactions of ten myoglobins in terms of substitutions in the antigenic sites and in environmental residues of the sites

1981 • 28 citations

Production of autoantibodies by immunization with rabbit myoglobin

1978 • 26 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: III. VARIANT A_β (bm 12) BUT NOT A_e (D2.GD) Ia POLYPEPTIDES ALTER IMMUNE RESPONSIVENESS TOWARDS THE α‐SUBUNIT OF HUMAN HAEMOGLOBIN

1981 • 26 citations

Immune recognition of cytochrome c. I. Investigation by synthesis whether antigenic sites of polymeric cytochrome coincide with locations of sequence differences between the immunizing and host cytochromes

1981 • 25 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: I. DEMONSTRATION OF SEPARATE GENETIC CONTROL OF THE RESPONSES TO THE α‐ AND β‐SUBUNITS BY IN VITRO LYMPHOCYTE PROLIFERATION

1981 • 24 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN:.

1981 • 23 citations

Immune recognition of serum albumin. 15

1982 • 23 citations

Antigenic determinants of influenza virus hemagglutinin—IX. The carbohydrate side chains from an Asian strain

1982 • 19 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN

1984 • 7 citations