Structurally inherent antigenic sites. Localization of the antigenic sites of the α-chain of human haemoglobin in three host species by a comprehensive synthetic approach

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

A simplified method for cyanogen bromide activation of agarose for affinity chromatography

1974 • 1,951 citations

Hydrolysis of Proteins with p-Toluenesulfonic Acid

1971 • 1,052 citations

Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic Model

1968 • 908 citations

Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins

1975 • 474 citations

Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2·5 Å resolution: Refinement of the atomic model

1975 • 431 citations

Die Konstitution des normalen adulten Humanhämoglobins

1961 • 386 citations

Preparation and Properties of α- and β-Chains from Human Hemoglobin

1969 • 363 citations

Precise determination of the entire antigenic structure of lysozyme: Molecular features of protein antigenic structures and potential of ‘surface-simulation’ synthesis—a powerful new concept for protein binding sites

1978 • 246 citations

Immunochemistry of sperm whale myoglobin. I. Specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen

1968 • 200 citations

Amino Acid Substitution and the Antigenicity of Globular Proteins

1975 • 163 citations

The Structure of Human Hemoglobin

1962 • 122 citations

Periodate oxidation of sperm-whale myoglobin and the role of the methionine residues in the antigen-antibody reaction

1967 • 115 citations

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the α-chain of human haemoglobin

1980 • 114 citations

Immunochemistry of sperm-whale myoglobin—XVI: Accurate delineation of the single region in sequence 1–55 by immunochemical studies of synthetic peptides. Some conclusions concerining antigenic structures of proteins

1974 • 104 citations

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites

1980 • 96 citations

Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites

1979 • 90 citations

The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species

1980 • 65 citations

Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin

1977 • 58 citations

Solid phase peptide synthesis

2002 • 54 citations

Localization and verification by synthesis of five antigenic sites of bovine serum albumin

1979 • 52 citations

The demonstration of two γ-globulin subclasses in the goat

1969 • 36 citations

Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal Autoreactivity in rabbits of antibodies to spermwhale myoglobin

1977 • 34 citations

The detection of five antigenically reactive regions in the soybean leghemoglobin a molecule

1978 • 31 citations

Antibodies to a continuous region at residues 38-54 of hen egg white lysozyme found in a small fraction of anti-hen egg white lysozyme antibodies

1980 • 31 citations

Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites

1980 • 27 citations

Haemoglobin binding with haptoglobin. Unequivocal demonstration that the β-chains of human haemoglobin bind to haptoglobin

1980 • 27 citations

Nearest-neighbour analysis of myoglobin antigenic sites. Nearest-neighbour residues whose replacement can alter the environment of binding-site residue(s) and thus change their characteristics and binding capability

1980 • 26 citations

Chemical studies on haemoglobins A1 and A0

1964 • 26 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN:.

1981 • 23 citations

Properties of goat anti-human hemoglobin antibodies fractionated on subunit affinity columns

1976 • 22 citations

Conformation-specific antibodies to the alpha chain COOH terminus of hemoglobin A0.

1979 • 17 citations

Enzymic and immunochemical properties of lysozome—XV

1976 • 15 citations

Immunochemistry of Proteins

1977 • 12 citations

Additional antigenic sites on human hemoglobin evident upon separation of antibody populations

1980 • 10 citations

Iodination of immunoadsorbed antibodies: Chloramine T vs lactoperoxidase

1977 • 8 citations

Faculty Opinion on Changes in Medical Education

1974 • 1 citations