X-Ray Crystallographic Studies of Immunoglobulins

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Structure of Hæmoglobin: A Three-Dimensional Fourier Synthesis at 5.5-Å. Resolution, Obtained by X-Ray Analysis

1960 • 1,270 citations

Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds

1960 • 901 citations

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

1969 • 869 citations

Progress in immunology

1968 • 577 citations

Electron microscopy of an antibody-hapten complex

1967 • 505 citations

Segmental flexibility in an antibody molecule

1970 • 465 citations

Antigenicity: Some Molecular Aspects

1969 • 418 citations

The Antibody Problem

1969 • 347 citations

Progress in Biophysics and Molecular Biology

1978 • 275 citations

Foetal “Antigens” in Cancer

1972 • 268 citations

THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS

1966 • 258 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

The Nature of an Antigenic Determinant

1966 • 217 citations

Molecular Mechanism of Formation of an Antigen–Antibody Complex

1965 • 184 citations

Bence-Jones Proteins and Light Chains of Immunoglobulins

1969 • 143 citations

Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization

1968 • 116 citations

Small angle x-ray scattering of a homogeneous γGl immunoglobulin

1970 • 110 citations

Structure of Fab New at 6 Å Resolution

1972 • 95 citations

The Use of X‐Ray Diffraction in the Study of Protein and Nucleic Acid Structure

1965 • 95 citations

Dissociation, Reaggregation, and Subunit Structure Studies of Some Human γM-Globulins

1967 • 93 citations

The Principles and Practice of Medicine.

1972 • 77 citations

Structure and Evolution of Kappa and Lambda Light Chains

1967 • 75 citations

The serological specificity of the poly-alanine immune system

1964 • 71 citations

Gross conformation of free polypeptide chains from rabbit immunoglobulin G. II. Light chain

1971 • 70 citations

A Structural Feature of Human Immunoglobulin Light Chains

1972 • 58 citations

Modifications in the Heterogeneity of the Antibody Response

1967 • 55 citations

A Crystallographic Investigation of a Human IgG Immunoglobulin

1970 • 47 citations

Crystallization of Fragment Fab of human IgG myeloma proteins

1968 • 47 citations

MAPPING OF THE COMBINING SITES OF ANTIBODIES SPECIFIC TO POLYALANINE CHAINS

1971 • 41 citations

A CRYSTALLINE _γ^G1 HUMAN MONOCLONAL PROTEIN WITH AN EXCESSIVE H CHAIN DELETION*

1971 • 35 citations

Affinity Labeling of the Heavy and Light Chains of a Myeloma Protein with Anti-2,4-Dinitrophenyl Activity

1970 • 35 citations

The Ultraviolet Rotatory Dispersion and Conformation of Bence-Jones Proteins

1966 • 33 citations

Electron microscopy of complexes between IgA (MOPC 315) and a bifunctional hapten

1971 • 33 citations

Properties of Crystallized Rabbit Anti-p-Azobenzoate Antibody

1967 • 33 citations

Gross conformation of free polypeptide chains from rabbit immunoglobulin G. I. Heavy chain

1971 • 30 citations

Peptide maps of rabbit γG-immunoglobulin heavy chains controlled by Allelic Genes

1966 • 29 citations

Human Fc fragment: Crystallographic evidence for two equivalent subunits

1968 • 29 citations

X-ray crystallographic study of the fab fragments from two human myeloma proteins

1969 • 28 citations

Studies on Fragments of Light Chains of Human Immunoglobulins: Genetic and Biochemical Implications

1967 • 27 citations

On the Structure of Antibody Active Sites

1967 • 27 citations

Structure of a λ-type Bence-Jones protein at 6-Ang. resolution

1972 • 27 citations

A Preliminary Crystallographic Investigation of a Human l-Type Bence-Jones Protein

1970 • 26 citations

Bence-Jones Proteins and Light Chains of Immunoglobulins

1970 • 26 citations

Crystallographic Data for the Fab Fragment of a Human Myeloma Immunoglobulin

1968 • 25 citations

Mercury derivatives of the Fab and Fc fragments of a human myeloma protein

1971 • 25 citations

CORRELATIONS BETWEEN AMINO ACID SEQUENCE AND CONFORMATION OF IMMUNOGLOBULIN LIGHT CHAINS

1969 • 24 citations

Crystallographic study of human myeloma Fc-fragment

1967 • 19 citations

Crystals of Fragment Fab′: Preparation from Pepsin Digests of Human IgG Myeloma Proteins

1969 • 18 citations

Crystallographic Studies of an IgG Immunoglobulin and the Bence-Jones Protein from One Patient

1972 • 18 citations

Localization of Affinity Lable within the Primary Structure of γ2 Chain from Guinea Pig IgG(2)**Supported by National Science Foundation Grant GB-7852.

1971 • 17 citations

Crystal Structure of an Immunoglobulin Molecule by X-Ray Diffraction and Electron Microscopy

1972 • 14 citations

Crystallographic Studies of Rabbit and Human Fc Fragments

1967 • 14 citations

Small-angle X-ray scattering of bence-jones protein

1963 • 12 citations

Papain fragmentation of rabbit γG-globulin: A crystallographic study

1966 • 12 citations

Health in the Tropics

1963 • 6 citations

X-Ray Crystallographic Studies of the Fab and Fc Fragments of Human Myeloma Immunoglobulins

1972 • 6 citations

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