Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Fc Receptors

1991 • 1,220 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Comparative studies of human FcRIII-positive and negative natural killer cells.

1989 • 688 citations

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

1989 • 574 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

Age-related changes in human blood lymphocyte subpopulations

1992 • 446 citations

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians [see comments]

1993 • 443 citations

Perforin: structure and function

1995 • 361 citations

Structure and function of human perforin

1988 • 346 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes

1992 • 281 citations

Differential age-change in the numbers of CD4+CD45RA+ DC4+CD29+ T cell subsets in human peripheral blood

1992 • 239 citations

Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies

1997 • 221 citations

Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing.

1987 • 170 citations

Cell-mediated cytotoxicity

1989 • 165 citations

Perforin dependence of natural killer cell‐mediated tumor control in vivo

1995 • 161 citations

Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

1992 • 158 citations

Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study

1994 • 147 citations

Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1989 • 144 citations

Studies of human natural killer cells. I. in vivo parameters affecting normal cytotoxic function

1982 • 130 citations

Characterization of three serine esterases isolated from human IL-2 activated killer cells.

1988 • 114 citations

Cell-mediated cytotoxicity

1993 • 108 citations

Lymphocyte‐mediated Cytotoxicity in vitro and in vivo: Mechanisms and Significance

1995 • 95 citations

Role of Perforin in Lymphocyte-Mediated Cytolysis

1992 • 89 citations

Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes

1995 • 88 citations

GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody.

1989 • 85 citations

Development of Natural Killer Cytotoxicity during Childhood: Marked Increases in Number of Natural Killer Cells with Adequate Cytotoxic Abilities during Infancy to Early Childhood

1990 • 84 citations

Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways

1995 • 78 citations

Characteristics of Perforin Expressing Lymphocytes Within the First Trimester Decidua of Human Pregnancy

1995 • 72 citations

Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease

1994 • 68 citations

Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene.

1993 • 65 citations

Functional significance of two cytolytic pathways of cytotoxic T lymphocytes

1995 • 61 citations

Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.

1992 • 60 citations

Perforins in human cytolytic cells: the effect of age

1996 • 59 citations

Age‐related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL‐associated serine esterase genes and the perforin gene in mice

1990 • 46 citations

Perforin‐Expressing Lymphocytes in Peripheral Blood and Decidua of Human First‐Trimester Pathological Pregnancies

1997 • 34 citations

PERFORIN EXPRESSION IN PERIPHERAL BLOOD LYMPHOCYTES IN REJECTING AND TOLERANT KIDNEY TRANSPLANT RECIPIENTS1

1996 • 31 citations

Simultaneous measurement of cell surface and intracellular antigens by multiple flow cytometry

1991 • 29 citations

Age-related decline in the lethal hit but not the binding stage of cytotoxic T-cell activity in mice

1988 • 26 citations

Increased perforin expression in multiple sclerosis patients during exacerbation of disease in peripheral blood lymphocytes

1997 • 24 citations

Functional importance of CD4⁺ and CD8⁺ cells in cytotoxic lymphocytes activity and associated gene expression. Impact on the age‐related decline in lytic activity

1991 • 16 citations

Pore‐forming protein in individual cytotoxic T lymphocytes: the effect of senescence provides a probe for understanding the lytic mechanism

1992 • 15 citations

Human decidual lymphocytes: Phenotype, perforin expression, and function

1994 • 13 citations

T-cell Mediated Cytotoxicity

1993 • 4 citations