Pore‐forming protein in individual cytotoxic T lymphocytes: the effect of senescence provides a probe for understanding the lytic mechanism

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Impaired Lymphocyte Function in Aged Humans

1974 • 350 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell.

1984 • 140 citations

Diminished calcium influx in lectin‐stimulated T cells from old mice

1987 • 133 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

1990 • 93 citations

Perforin‐Dependent and ‐Independent Pathways of Cytotoxicity Mediated by Lymphocytes

1988 • 86 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

Quantification of natural cytotoxicity by human lymphocyte subpopulations isolated by density: Heterogeneity of the effector cells

1983 • 76 citations

The Decline of Cell-mediated Immunity in Aging Mice

1974 • 63 citations

Change of Cell-Mediated Cytotoxicity with Aging

1975 • 59 citations

Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice

1989 • 55 citations

Age‐related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL‐associated serine esterase genes and the perforin gene in mice

1990 • 46 citations

Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli.

1988 • 38 citations

Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets.

1992 • 37 citations

Generation propagation, and targeting of human CD4+ helper/killer T cells induced by anti-CD3 monoclonal antibody plus recombinant IL-2. An efficient strategy for adoptive tumor immunotherapy.

1992 • 35 citations

How Killer Cells Kill

1988 • 35 citations

Age-related decline in the lethal hit but not the binding stage of cytotoxic T-cell activity in mice

1988 • 26 citations

Functional importance of CD4⁺ and CD8⁺ cells in cytotoxic lymphocytes activity and associated gene expression. Impact on the age‐related decline in lytic activity

1991 • 16 citations