Transgenic mice expressing human apolipoprotein A-I have sera with modest trypanolytic activity in vitro but remain susceptible to infection by Trypanosoma brucei brucei.

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

High density lipoprotein metabolism.

1984 • 1,230 citations

Trypanosoma brucei: A rapid “matching” method for estimating the host's parasitemia

1976 • 664 citations

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

1990 • 660 citations

DEVELOPMENTAL CYCLES AND BIOLOGY OF PATHOGENIC TRYPANOSOMES

1985 • 622 citations

Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad.

1983 • 490 citations

Transgenic Animals

1988 • 473 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

[3] Comparative analysis of mammalian plasma lipoproteins

1986 • 318 citations

[32] Reconstitution of high-density lipoproteins

1986 • 316 citations

Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.

1991 • 272 citations

Identification of the trypanocidal factor in normal human serum: high density lipoprotein.

1978 • 208 citations

[10] Isolation and characterization of apolipoproteins A-I, A-II, and A-IV

1986 • 177 citations

Lysis of Trypanosoma brucei by a Toxic Subspecies of Human High Density Lipoprotein

1989 • 176 citations

[9] Delipidation of plasma lipoproteins

1986 • 117 citations

The testing of proven Trypanosoma brucei and T. rhodesiense strains by the blood incubation infectivity test.

1970 • 105 citations

Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure.

1990 • 105 citations

On computer-assisted analysis of biological sequences: proline punctuation, consensus sequences, and apolipoprotein repeats.

1990 • 100 citations

Degradation and reassembly of a human serum high-density lipoprotein. Evidence for differences in lipid affinity among three classes of polypeptide chains

1970 • 96 citations

Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I.

1989 • 95 citations

Expression of the human apolipoprotein A-I gene in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesteryl esters.

1991 • 72 citations

A Survey for a Trypanocidal Factor in Primate Sera

1990 • 55 citations

Studies in Chemotherapy

1930 • 55 citations

Trypanosoma brucei: Some properties of the cytotoxic reaction induced by normal human serum

1978 • 53 citations

Regulation of intestinal apolipoprotein B synthesis and secretion by Caco-2 cells. Lack of fatty acid effects and control by intracellular calcium ion.

1988 • 49 citations

Characteristics of the binding of human and bovine high-density lipoproteins by bloodstream forms of the African trypanosome, Trypanosoma brucei brucei

1992 • 46 citations

The trypanocidal action of human serum and of baboon plasma

1973 • 46 citations

[34] Reconstitution of the hydrophobic core of low-density lipoprotein

1986 • 43 citations

The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense

1976 • 42 citations

The differentiation of Trypanosoma rhodesiense from T. brucei by means of human serum

1973 • 29 citations

Comparison of the cytolytic effects in vitro on Trypanosoma brucei brucei of plasma, high density lipoproteins, and apolipoprotein A-I from hosts both susceptible (cattle and sheep) and resistant (human and baboon) to infection.

1992 • 26 citations

Trypanosoma brucei: Cytotoxicity of host high-density lipoprotein is not mediated by apolipoprotein A-I

1991 • 22 citations

Trypanosoma brucei brucei: differences in the trypanocidal activity of human plasma and its relationship to the level of high density lipoproteins

1991 • 21 citations

Interaction of high‐density lipoprotein with Trypanosoma brucei: Effect of membrane stabilizers

1983 • 20 citations

Role of phospholipids in the cytotoxic action of high density lipoprotein on trypanosomes

1991 • 18 citations

Nature of the trypanocidal factor in human serum.

1989 • 18 citations

Nature of the Trypanocidal Factor in Human Serum

1989 • 14 citations

Some supplementary observations on the blood incubation infectivity test.

1972 • 12 citations

Apolipoprotein variation among different species

1991 • 9 citations

The action of human serum upon Trypanosoma brucei.

1979 • 8 citations

The use of gene targeting to develop animal models for human genetic diseases

1990 • 7 citations