Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure.

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

High density lipoprotein as a protective factor against coronary heart disease

1977 • 5,019 citations

The plasma lecithin:cholesterol acyltransferase reaction

1968 • 2,415 citations

Plasma lipoproteins: apolipoprotein structure and function.

1984 • 1,130 citations

A protein cofactor of lecithin:Cholesterol acyltransferase

1972 • 722 citations

Structure and variation of human α1–antitrypsin

1982 • 616 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

ARE APOLIPOPROTEINS BETTER DISCRIMINATORS THAN LIPIDS FOR ATHEROSCLEROSIS?

1979 • 547 citations

Studies of the Proteins in Human Plasma Very Low Density Lipoproteins

1969 • 467 citations

Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin. Cholesterol acyltransferase

1975 • 392 citations

Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine.

1985 • 314 citations

Familial Deficiency of Apolipoproteins A-I and C-III and Precocious Coronary-Artery Disease

1982 • 308 citations

Secondary structures of proteins and peptides in amphiphilic environments. (A review).

1983 • 299 citations

Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots

1986 • 277 citations

Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia.

1988 • 249 citations

Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages.

1985 • 245 citations

Isolation and characterization of the human apolipoprotein A-I gene.

1983 • 243 citations

Variant apolipoprotein AI as a major constituent of a human hereditary amyloid

1988 • 229 citations

Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.

1987 • 215 citations

Structure and evolution of the apolipoprotein multigene family

1986 • 214 citations

The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide.

1980 • 204 citations

Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface.

1987 • 193 citations

Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes.

1986 • 190 citations

Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.

1983 • 161 citations

PHYLOGENIES CONSTRAINED BY THE CROSSOVER PROCESS AS ILLUSTRATED BY HUMAN HEMOGLOBINS AND A THIRTEEN-CYCLE, ELEVEN-AMINO-ACID REPEAT IN HUMAN APOLIPOPROTEIN A-I

1977 • 152 citations

Spontaneous mutation rates at enzyme loci in Drosophila melanogaster.

1977 • 148 citations

Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

1988 • 134 citations

Identification of apolipoproteins involved in the interaction of human high density lipoprotein3 with receptors on cultured cells.

1985 • 130 citations

Repeated helical pattern in apolipoprotein-A-I

1977 • 120 citations

AIMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission.

1985 • 119 citations

Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.

1984 • 103 citations

Studies of synthetic peptide analogs of the amphipathic helix. Correlation of structure with function.

1985 • 102 citations

Familial apolipoprotein A-I and C-III deficiency, variant II.

1985 • 98 citations

Comparative analysis of repeated sequences in rat apolipoproteins A-I, A-IV, and E.

1985 • 95 citations

Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I.

1989 • 95 citations

Lipid-Protein Interactions in High Density Lipoproteins

1974 • 92 citations

Hybridisoelectric focusing in rehydrated immobilized pH gradients with added carrier ampholytes: Demonstration of human globins

1985 • 92 citations

Chain length-function correlation of amphiphilic peptides. Synthesis and surface properties of a tetratetracontapeptide segment of apolipoprotein A-I.

1980 • 76 citations

Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids.

1985 • 73 citations

Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type.

1984 • 67 citations

Apolipoprotein A‐I_Giessen (Pro¹⁴³→Arg)

1984 • 60 citations

Studies of synthetic peptide analogs of the amphipathic helix. Competitive displacement of exchangeable apolipoproteins from native lipoproteins.

1983 • 50 citations

Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.

1987 • 49 citations

High performance liquid chromatography and time-of-flight secondary ion mass spectrometry: a new dimension in structural analysis of apolipoproteins.

1988 • 36 citations

Pouring reproducible gradients in gels under computer control: new devices for simultaneous delivery of two independent gradients, for more flexible slope and pH range of immobilized pH gradients.

1984 • 36 citations

Structure and expression of dog apolipoprotein C-II and C-III mRNAs. Implications for the evolution and functional constraints of apolipoprotein structure.

1987 • 35 citations

Apolipoprotein AIMarburg: Studies on two kindreds with a mutant of human apolipoprotein AI

1982 • 33 citations

Activation of phosphatidylcholine–sterol acyltransferase by human apolipoprotein E isoforms

1985 • 32 citations

The complete sequence of chick apolipoprotein AI mRNA and its expression in the developing chick

1987 • 32 citations

Functional differentiation of amphiphilic helices of the apolipoproteins by hydrophobic moment analysis

1987 • 25 citations

A revised estimate of the amount of genetic variation in human proteins: implications for the distribution of DNA polymorphisms.

1984 • 25 citations

The primary structure of cynomolgus monkey apolipoprotein a-1 deduced from the cdna sequence: comparison to the human sequence

1986 • 21 citations

Apolipoprotein A-I (Glu 198→Lys): A Mutant of the Major Apolipoprotein of High-Density Lipoproteins Occurring in a Family with Dyslipoproteinemia

1988 • 17 citations

Genetic studies of an apoA-I lipoprotein variant

1983 • 15 citations