Signaling mechanisms of elevated neutrophil O 2 − generation after burn injury

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Adult Respiratory-Distress Syndrome

1982 • 554 citations

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.

1982 • 554 citations

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

1984 • 520 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

The pulmonary vascular lesions of the adult respiratory distress syndrome.

1983 • 418 citations

Hypermetabolism, organ failure, and metabolic support.

1987 • 362 citations

Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils.

1982 • 309 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes.

1974 • 230 citations

Ca2+ imaging in single living cells: Theoretical and practical issues

1990 • 215 citations

Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.

1989 • 213 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage

1988 • 196 citations

Protein kinase C in transmembrane signalling

1990 • 194 citations

Oxygen Radical Dependent Lung Damage following Thermal Injury of Rat Skin

1983 • 182 citations

Burns

1985 • 176 citations

Development and analysis of a small animal model simulating the human postburn hypermetabolic response

1978 • 175 citations

Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage

1988 • 158 citations

Generation of superoxide radicals by human peripheral neutrophils activated by chemotactic factor. Evidence for the role of calcium.

1979 • 156 citations

Tyrosine phosphorylation in human neutrophil

1989 • 140 citations

Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size.

1987 • 130 citations

Protein kinase C isotypes and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC

1993 • 126 citations

The respiratory burst oxidase

1987 • 121 citations

The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.

1987 • 117 citations

Primed stimulation of isolated perfused rabbit lung by endotoxin and platelet activating factor induces enhanced production of thromboxane and lung injury.

1990 • 105 citations

Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages.

1972 • 99 citations

Multiple Organ Failure

1990 • 98 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Activation of the respiratory burst oxidase in neutrophils: On the role of membrane-derived second messengers, Ca++, and protein kinase C

1988 • 83 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

Calcium channel blockers nifedipine and diltiazem inhibit Ca2+ release from intracellular stores in neutrophils.

1992 • 78 citations

Complement Activation and Hematologic, Hemodynamic, and Respiratory Reactions Early after Soft-tissue Injury

1978 • 76 citations

Calcium channel antagonist induced inhibition of superoxide production in human neutrophils

1986 • 70 citations

N-Acetylsphingosine (C2--ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx

1995 • 68 citations

[22] Assays of plasma membrane NADPH oxidase

1994 • 59 citations

Neutrophil stimulation: receptor, membrane, and metabolic events.

1984 • 57 citations

The role of the neutrophil in inflammatory diseases of the lung.

1990 • 57 citations

Calcium Channel Blockade Inhibits Release of TNFα and Improves Survival in a Rat Model of Acute Pancreatitis

1996 • 42 citations

Humoral-Phagocyte Axis of Immune Defense in Burn Patients

1982 • 39 citations

Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox

1996 • 39 citations

Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox

1996 • 39 citations

Oxidative Activity of Polymorphonuclear Leukocytes After Thermal Injury

1989 • 36 citations

Verapamil impairs human neutrophil chemotaxis by a non-calcium-mediated mechanism.

1986 • 34 citations

Inhibition by verapamil of neutrophil responses to formylmethionylleucylphenylalanine and phorbol myristate acetate. Mechanisms involving Ca2+ changes, cyclic AMP and protein kinase C

1985 • 30 citations

Temporal analysis of human leucocyte surface antigen expression and neutrophil respiratory burst activity after thermal injury

1993 • 30 citations

Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1981 • 28 citations

Auranofin modulated cytoplasmic free calcium in neutrophils by mobilizing intracellular calcium and inhibiting protein kinase.

1990 • 25 citations

Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity

1987 • 22 citations

Granulocyte oxidative activity after thermal injury.

1992 • 21 citations

Protein kinases potentially capable of catalyzing the phosphorylation of p47-phox in normal neutrophils and neutrophils of patients with chronic granulomatous disease

1993 • 18 citations

In vitro modulation of human neutrophil superoxide anion generation by various calcium channel antagonists used in ischemia-reperfusion resuscitation

1989 • 18 citations

Medical progress. Burns.

1986 • 15 citations

ELEVATED EXPRESSION OF p47PHOX AND p67PHOX PROTEINS IN NEUTROPHILS FROM BURNED RATS

1997 • 13 citations

Inhibition by calcium channel blockers of the binding of platelet-activating factor to human neutrophil granulocytes

1990 • 13 citations

Parameters of neutrophil activation: models of priming and deactivation.

1989 • 12 citations

Inhibition of human neutrophil function by tolfenamic acid involves inhibition of Ca2+ influx

1995 • 8 citations

Inositol phosphates. Metabolism and site of action in neutrophil granulocytes.

1992 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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