Cooperative interaction between Bcl-2 and Epstein-Barr virus latent membrane protein 1 in the growth transformation of human epithelial cells.

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA

1964 • 2,643 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells

1985 • 1,257 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Expression of Epstein–Barr Virus Transformation–Associated Genes in Tissues of Patients with EBV Lymphoproliferative Disease

1989 • 803 citations

Cooperation between oncogenes

1991 • 792 citations

Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.

1993 • 778 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis

1991 • 525 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

Epstein--Barr Virus Gene Expression in Nasopharyngeal Carcinoma

1988 • 479 citations

Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma

1988 • 447 citations

Antibodies to Epstein-Barr Virus in Nasopharyngeal Carcinoma, Other Head and Neck Neoplasms, and Control Groups<xref ref-type="fn" rid="FN2">2</xref>

1970 • 405 citations

Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity

1988 • 403 citations

Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation

1993 • 392 citations

Epstein–Barr virus latent membrane protein inhibits human epithelial cell differentiation

1990 • 377 citations

The role of c-myc in cell growth

1993 • 365 citations

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

1990 • 299 citations

Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

1988 • 280 citations

Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells

1985 • 274 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6

1990 • 249 citations

Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus

1986 • 232 citations

Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers

1994 • 207 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

Bcl‐2 proto‐oncogene expression in epstein‐barr‐virus‐associated nasopharyngeal carcinoma

1993 • 198 citations

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation

1991 • 194 citations

The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis (review).

1990 • 169 citations

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

1990 • 157 citations

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1990 • 147 citations

Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells.

1989 • 131 citations

An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes.

1987 • 121 citations

bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells [published erratum appears in J Cell Biol 1995 Nov;131(4):following 1121]

1995 • 106 citations

Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2

1993 • 77 citations

Induction of apoptosis in epithelial cells by Epstein--Barr virus latent membrane protein 1

1996 • 58 citations

Complementation by BCL2 and C-HA-RAS Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts

1990 • 42 citations

Immunofluorescent quantification of ribonucleotide reductase M1 subunit and correlation with DNA content by flow cytometry

1987 • 42 citations

Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts*1

1991 • 39 citations

BCL-2 ONCOGENE BLOCKS DIFFERENTIATION AND EXTENDS VIABILITY BUT DOES NOT IMMORTALIZE NORMAL HUMAN KERATINOCYTES

1994 • 15 citations