Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells

1985 • 1,257 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy

1982 • 822 citations

Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.

1993 • 778 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

1987 • 735 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23

1990 • 585 citations

Genetic analysis of immortalizing functions of Epstein–Barr virus in human B lymphocytes

1989 • 553 citations

Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis

1991 • 525 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B.

1992 • 416 citations

Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity

1988 • 403 citations

Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation

1993 • 392 citations

Epstein–Barr virus latent membrane protein inhibits human epithelial cell differentiation

1990 • 377 citations

Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes

1992 • 360 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

Different Epstein--Barr virus--B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line

1990 • 347 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein

1984 • 311 citations

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

1990 • 299 citations

Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

1988 • 280 citations

Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells

1985 • 274 citations

Monoclonal Antibodies to the Latent Membrane Protein of Epstein-Barr Virus Reveal Heterogeneity of the Protein and Inducible Expression in Virus-transformed Cells

1987 • 267 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus

1986 • 232 citations

Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: implications for sites of viral latency.

1988 • 222 citations

Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity

1992 • 211 citations

Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells

1992 • 206 citations

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation

1991 • 194 citations

Epstein‐barr virus‐infected b cells persist in the circulation of acyclovir‐treated virus carriers

1989 • 180 citations

5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael

1989 • 149 citations

Expression of bcl-2 in Burkitt's lymphoma cell lines: induction by latent Epstein-Barr virus genes

1992 • 133 citations

Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes

1993 • 103 citations

Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellular activation and DNA synthesis.

1992 • 101 citations

Epstein‐Barr virus status and tumour cell phenotype in sporadic Burkitt's lymphoma

1986 • 96 citations

Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association

1991 • 91 citations

HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families.

1993 • 87 citations

Flow cytometric detection of the mitochondrial BCL‐2 protein in normal and neoplastic human lymphoid cells

1992 • 81 citations

Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2

1993 • 77 citations

Transient expression of the Epstein-Barr virus LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells, and hematopoietic cell lines: cell-type-independent-induction of CD23, CD21, and ICAM-1.

1993 • 53 citations

Epstein-Barr virus, lymphomas and Hodgkin's disease.

1992 • 50 citations

A 5' Portion of the ICAM-1 Gene Confers Tissue-Specific Differential Expression Levels and Cytokine Responsiveness

1993 • 46 citations

HIV-1 Induces Down-Regulation of bcl-2 Expression and Death by Apoptosis of EBV-Immortalized B Cells: A Model for a Persistent "Self-Limiting" HIV-1 Infection

1994 • 40 citations

The latent membrane protein oncoprotein resembles growth factor receptors in the properties of its turnover.

1991 • 37 citations

Signal transduction through the T cell receptor-CD3 complex. Evidence for heterogeneity in receptor coupling.

1990 • 34 citations