Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Genomic sequencing.

1984 • 8,343 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

A series of normal stages in the development of the chick embryo

1992 • 1,860 citations

Vertebrate Paleontology and Evolution

1988 • 1,723 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

1997 • 1,066 citations

Gene duplications and the origins of vertebrate development

1994 • 951 citations

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1997 • 909 citations

Fossils, genes and the evolution of animal limbs

1997 • 796 citations

Vertebrate paleontology and evolution

1988 • 749 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

Vertebrate Limb and Somite Morphogenesis

1979 • 613 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

1997 • 536 citations

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1997 • 529 citations

Analysis of Hox gene expression in the chick limb bud

1996 • 480 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 335 citations

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

1995 • 318 citations

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 314 citations

The T-box gene family

1998 • 307 citations

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

1995 • 303 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Mesoderm formation in response to Brachyury requires FGF signalling

1995 • 276 citations

Evidence of a role for T-☐ genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

1996 • 271 citations

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

1995 • 268 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

Hox9 genes and vertebrate limb specification

1997 • 214 citations

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

1997 • 208 citations

Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds.

1995 • 205 citations

Evolution of Mouse T-box Genes by Tandem Duplication and Cluster Dispersion

1996 • 189 citations

Ectoderm — mesoderm relationship in the development of the chick embryo limb bud

1955 • 176 citations

Ectodermal control of the dorsoventral axis in the leg bud of the chick embryo,

1974 • 159 citations

Morphogenetic and axial self‐differentiation of transplanted limb primordia of 2‐day chick embryos

1938 • 156 citations

Vertebrate limb development

1995 • 154 citations

Expression of T-box genes Tbx2–Tbx5 during chick organogenesis

1998 • 147 citations

The influence of embryonic mesoderm on the regional specification of epidermal derivatives in the chick

1954 • 125 citations

The role of the apical ridge of ectoderm in the differentiation of the morphological structure and inductive specificity of limb parts in the chick

1957 • 123 citations

Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4

1998 • 119 citations

An Additional Limb Can Be Induced from the Flank of the Chick Embryo by FGF4

1995 • 105 citations

The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure

1997 • 98 citations

Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity

1995 • 97 citations

The differentiation of prospective thigh mesoderm grafted beneath the apical ectodermal ridge of the wing bud in the chick embryo

1959 • 91 citations

Control of cell fate and polarity in the adult abdominal segments of Drosophila by optomotor-blind

1997 • 78 citations

Wholemount in situ hybridization of vertebrate embryos

1992 • 78 citations

Discovering fossil fishes

1996 • 73 citations

The effect of removing posterior apical ectodermal ridge of the chick wing and leg on pattern formation

1981 • 47 citations

The ulnar‐mammary syndrome: an autosomal dominant pleiotropic gene

1987 • 47 citations

Newly Identified Paralogous Groups on Mouse Chromosomes 5 and 11 Reveal the Age of a T-Box Cluster Duplication

1997 • 43 citations

Limb mutants: what can they tell us about normal limb development?

1997 • 41 citations

Genetics and limb development

1996 • 35 citations

Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb

1995 • 13 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 13 citations

Chick Limb Buds

1993 • 3 citations

Deleted Work

1955 • 0 citations