A propagated wave of mpf activation accompanies surface contraction waves at first mitosis in xenopus

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.

1980 • 358 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control

1996 • 338 citations

The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle

1987 • 312 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

1995 • 279 citations

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

1991 • 279 citations

The metaphase II arrest in mouse oocytes is controlled through microtubule-dependent destruction of cyclin B in the presence of CSF.

1993 • 273 citations

Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.

1992 • 271 citations

On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.

1991 • 262 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesis.

1992 • 197 citations

Severing of stable microtubules by a mitotically activated protein in xenopus egg extracts

1991 • 196 citations

Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation.

1991 • 176 citations

Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis.

1983 • 169 citations

Cyclin B targets p34cdc2 for tyrosine phosphorylation.

1991 • 152 citations

In VivoRegulation of the Early Embryonic Cell Cycle inXenopus

1996 • 148 citations

Cell cycle control of microtubule-based membrane transport and tubule formation in vitro.

1991 • 142 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.

1994 • 126 citations

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

1995 • 123 citations

Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control.

1993 • 122 citations

Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.

1990 • 109 citations

Evidence for the involvement of microtubules, ER, and kinesin in the cortical rotation of fertilized frog eggs.

1991 • 100 citations

Dynamics of Germ Plasm Localization and Its Inhibition by Ultraviolet Irradiation in Early Cleavage Xenopus Embryos

1993 • 95 citations

p34^cdc2 Kinase is localized to distinct domains within the mitotic apparatus

1990 • 91 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Effect on microtubule dynamics of XMAP230, a microtubule-associated protein present in Xenopus laevis eggs and dividing cells [published erratum appears in J Cell Biol 1995 Mar;128(5):following 988]

1994 • 87 citations

Cinematographic observation of ?surface contraction waves? (SCW) during the early cleavage of axolotl eggs

1971 • 75 citations

cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells.

1992 • 72 citations

Surface contraction waves in amphibian eggs

1982 • 67 citations

Organization and regulation of cortical microtubules during the first cell cycle ofXenopuseggs

1992 • 63 citations

Role of nuclear material in the early cell cycle of xenopus embryos

1988 • 61 citations

Distribution of the cytoplasmic activity inducing germinal vesicle breakdown in frog oocytes

1972 • 61 citations

The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm

1997 • 60 citations

CYCLIC SURFACE CHANGES IN THE NON‐NUCLEATE EGG FRAGMENT OF XENOPUS LAEVIS

1981 • 54 citations

An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts.

1996 • 38 citations

The interval of the cytoplasmic cycle observed in non-nucleate egg fragments is longer than that of the cleavage cycle in normal eggs of Xenopus laevis

1983 • 37 citations

Axis establishment and microtubule-mediated waves prior to first cleavage in Beroe ovata

1993 • 37 citations

The Egg Nucleus Regulates the Behavior of Sperm Nuclei as Well as Cycling of MPF in Physiologically Polyspermic Newt Eggs

1993 • 29 citations

Localization of the factors producing the periodic activities responsible for synchronous cleavage in Xenopus embryos.

1985 • 26 citations

Independence of two microtubule systems in fertilized frog eggs: the sperm aster and the vegetal parallel array

1993 • 24 citations

Purification of microtubule proteins from Xenopus egg extracts: Identification of a 230K MAP4‐like protein

1994 • 21 citations

Microtubule-entrained kinase activities associated with the cortical cytoskeleton during cytokinesis

1997 • 18 citations

Cytoplasmic and cortical factors participating in cleavage furrow formation in eggs of three amphibian genera; Ambystoma, Xenopus and Cynops

1983 • 11 citations

Insensitivity to cytochalasin B of surface contractions keyed to cleavage in the Xenopus egg.

1982 • 11 citations

Relative Timing of Stiffening with Various Combinations of Nucleate and Enucleated Egg Fragments of Xenopus laevis

1992 • 10 citations

Nuclear Involvement in Localization of the Initiation Site of Surface Contraction Waves in Xenopus Eggs

1989 • 9 citations

Subcellular distribution of aster‐nucleated microtubule length: A more or less mitotic status of cytoplasmic areas during meiosis I of starfish oocytes

1994 • 9 citations

Furrow Formation in the Vegetal Hemisphere of Xenopus Eggs

1993 • 3 citations