Molecular Biology of P2X Purinoceptors

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

A proton-gated cation channel involved in acid-sensing

1997 • 1,314 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Purinoceptors: Are there families of P2X and P2Y purinoceptors?

1994 • 1,079 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

Primary structure and functional expression of a mouse inward rectifier potassium channel

1993 • 1,004 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

A basis for distinguishing two types of purinergic receptor

1978 • 725 citations

A transient calcium‐dependent chloride current in the immature Xenopus oocyte.

1983 • 627 citations

The past, present and future of purine nucleotides as signalling molecules

1997 • 550 citations

ATP mediates fast synaptic transmission in mammalian neurons

1992 • 549 citations

The Permeabilizing ATP Receptor, P2X7

1997 • 486 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Distinct ATP receptors on pain-sensing and stretch-sensing neurons

1997 • 452 citations

Suramin: a reversible P₂‐purinoceptor antagonist in the mouse vas deferens

1988 • 426 citations

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals

1997 • 418 citations

Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.

1996 • 405 citations

An antagonist-insensitive P2X receptor expressed in epithelia and brain.

1996 • 404 citations

Nucleotide receptors

1997 • 399 citations

Further subclassification of ATP receptors based on agonist studies

1991 • 374 citations

Purinergic receptors: their role in nociception and primary afferent neurotransmission

1996 • 356 citations

P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

1996 • 339 citations

Receptor for ATP in the membrane of mammalian sensory neurones

1983 • 335 citations

P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

1995 • 323 citations

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1995 • 319 citations

Suramin antagonizes responses to P₂‐purinoceptor agonists and purinergic nerve stimulation in the guinea‐pig urinary bladder and taenia coli

1990 • 317 citations

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

1997 • 306 citations

Cell membrane receptors for drugs and hormones : a multidisciplinary approach

1978 • 282 citations

Recent research on the biological activity of suramin.

1993 • 281 citations

A P2X purinoceptor cDNA conferring a novel pharmacological profile

1995 • 279 citations

P2x receptors bring new structure to ligand-gated ion channels

1995 • 277 citations

The regulation of vascular function by P2 receptors: multiple sites and multiple receptors

1998 • 274 citations

P2X Receptors: An Emerging Channel Family

1996 • 265 citations

ATP P_2XReceptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal Cord

1997 • 264 citations

Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.

1996 • 257 citations

P₂‐purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P_2y‐ but not the P_2x‐purinoceptor

1987 • 245 citations

Pore loops: An emerging theme in ion channel structure

1995 • 237 citations

Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization.

1994 • 235 citations

The ATP4- receptor of rat mast cells

1980 • 227 citations

Characterization of Recombinant Human P2X₄ Receptor Reveals Pharmacological Differences to the Rat Homologue

1997 • 220 citations

Identification of amino acid residues contributing to the pore of a P2X receptor

1997 • 207 citations

Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones.

1995 • 200 citations

The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes

1997 • 195 citations

Signal Transduction by P₂-Purinergic Receptors for Extracellular ATP

1991 • 193 citations

ATP mediates fast synaptic potentials in enteric neurons

1994 • 188 citations

Different Sensitivities to pH of ATP-Induced Currents at Four Cloned P2X Receptors

1997 • 181 citations

Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides

1989 • 172 citations

How should P2x purinoceptors be classified pharmacologically?

1995 • 163 citations

Desensitization of the P2X₂ receptor controlled by alternative splicing

1997 • 160 citations

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels

1995 • 156 citations

ATP‐activated channels gate calcium entry in single smooth muscle cells dissociated from rabbit ear artery.

1989 • 153 citations

Families of ion channels with two hydrophobic segments

1996 • 150 citations

Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors

1998 • 149 citations

Role of ATP in fast excitatory synaptic potentials in locus coeruleus neurones of the rat

1997 • 146 citations

ATP-activated channels in rat and bullfrog sensory neurons: current- voltage relation and single-channel behavior

1990 • 145 citations

Effects of extracellular pH on agonism and antagonism at a recombinant P2X₂ receptor

1997 • 144 citations

Purines and their roles in apoptosis

1997 • 144 citations

Domains of P2X receptors involved in desensitization

1996 • 140 citations

Localization and Functional Expression of Splice Variants of the P2X₂Receptor

1997 • 140 citations

Localization of P2X purinoceptor transcripts in the rat nervous system.

1995 • 139 citations

ATP is a potent stimulator of the activation and formation of rodent osteoclasts

1998 • 138 citations

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method.

1998 • 136 citations

Full sensitivity of P_2times2 purinoceptor to ATP revealed by changing extracellular pH

1996 • 136 citations

The structure-activity relationships of ectonucleotidases and of excitatory P2-purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency

1987 • 134 citations

An ATP‐activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.

1990 • 129 citations

Molecular cloning and functional expression of a novel rat heart P2X purinoceptor

1996 • 126 citations

P1- and P2-purinoceptor subtypes--an update.

1990 • 126 citations

Baculovirus Expression Provides Direct Evidence for Heteromeric Assembly of P2X₂and P2X₃Receptors

1997 • 123 citations

ATP analogues and the guinea-pig taenia coli: a comparison of the structure-activity relationships of ectonucleotidases with those of the P2-purinoceptor

1986 • 123 citations

Neuronal ATP receptors and their mechanism of action

1993 • 119 citations

Characterization of P2‐purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electrophysiological responses

1994 • 118 citations

Different P2-purinergic receptor subtypes of endothelium and smooth muscle in canine blood vessels.

1987 • 117 citations

Selective antagonism by PPADS at P_2X‐purinoceptors in rabbit isolated blood vessels

1994 • 117 citations

Characterization and chromosomal localization of a human P2X receptor from the urinary bladder.

1995 • 117 citations

A Domain Contributing to the Ion Channel of ATP-Gated P2X₂Receptors Identified by the Substituted Cysteine Accessibility Method

1998 • 117 citations

Zn2+ potentiates ATP-activated currents in rat sympathetic neurons

1993 • 114 citations

UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y ₂ receptor

1997 • 113 citations

The Involvement of an ATP-Gated Ion Channel, P2X1, in Thymocyte Apoptosis

1996 • 110 citations

Cloning and Tissue Distribution of a Novel P2X Receptor from Rat Brain

1996 • 109 citations

Zn2+ potentiates excitatory action of ATP on mammalian neurons.

1993 • 107 citations

Coexpression of mRNAs for P2X<sub>1</sub>, P2X<sub>2</sub> and P2X<sub>4</sub> Receptors in Rat Vascular Smooth Muscle: An in situ Hybridization and RT-PCR Study

1998 • 106 citations

Molecular characterization and pharmacological properties of the human P2X3 purinoceptor

1997 • 105 citations

P2X purinoceptors in cultured myenteric neurons of guinea‐pig small intestine.

1996 • 101 citations

The antagonist trinitrophenyl‐ATP reveals co‐existence of distinct P2X receptor channels in rat nodose neurones

1998 • 101 citations

Characterization of a P_2X‐purinoceptor in cultured neurones of the rat dorsal root ganglia

1996 • 97 citations

Pharmacological analysis of ecto‐ATPase inhibition: evidence for combined enzyme inhibition and receptor antagonism in P_2X‐purinoceptor ligands

1994 • 96 citations

Cloning and Pharmacological Characterization of a Fourth P2X Receptor Subtype Widely Expressed in Brain and Peripheral Tissues Including Various Endocrine Tissues

1996 • 94 citations

Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system

1997 • 92 citations

Pharmacological properties of P2X₃‐receptors present in neurones of the rat dorsal root ganglia

1998 • 91 citations

P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore‐forming P2Z‐like phenotype

1997 • 91 citations

Identification of a unique membrane receptor for adenosine 5‘,5“‘-P1,P4-tetraphosphate.

1991 • 90 citations

Receptors for ATP in rat sensory neurones: the structure‐function relationship for ligands

1988 • 89 citations

Zn²⁺ modulation of ATP‐responses at recombinant P2X₂ receptors and its dependence on extracellular pH

1998 • 89 citations

The P2 Nucleotide Receptors

1998 • 85 citations

Cloning of P2XM, a novel human P2X receptor gene regulated by p53.

1997 • 84 citations

P2 purinoceptors : localization, function, and transduction mechanisms

1996 • 82 citations

New insights on P2X purinoceptors

1995 • 80 citations

P_2x‐purinoceptors of myenteric neurones from the guinea‐pig ileum and their unusual pharmacological properties

1996 • 76 citations

Identification of a Short Form of the P2xR1-Purinoceptor Subunit Produced by Alternative Splicing in the Pituitary and Cochlea

1995 • 76 citations

P2X purinoceptor plethora

1996 • 76 citations

The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci

1989 • 72 citations

Distribution and Roles of Purinoceptor Subtypes

1991 • 71 citations

P₂ receptor: Subclassification and structure‐activity relationships

1993 • 70 citations

A study on P₂x purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens

1995 • 69 citations

Nonselective cationic currents elicited by extracellular ATP in human B-lymphocytes

1995 • 69 citations

P2X receptors in autonomic and sensory neurons

1996 • 67 citations

The human P2×1 receptor: molecular cloning, tissue distribution, and localization to chromosome 171

1996 • 67 citations

Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons

1996 • 65 citations

Expression of the P2X2 receptor subunit of the ATP-gated ion channel in the retina

1997 • 65 citations

Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart

1998 • 64 citations

Potentiation of ATP‐responses at a recombinant P_2X2 receptor by neurotransmitters and related substances

1997 • 64 citations

Block by calcium of ATP-activated channels in pheochromocytoma cells.

1993 • 63 citations

Properties of ATP receptor-mediated synaptic transmission in the rat medial habenula

1997 • 62 citations

A Pyridoxine Cyclic Phosphate and Its 6-Azoaryl Derivative Selectively Potentiate and Antagonize Activation of P2X₁ Receptors

1998 • 61 citations

Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells

1996 • 56 citations

Solubilization and molecular size determination of the P2x purinoceptor from rat vas deferens.

1992 • 55 citations

An assessment of the antagonistic activity of reactive blue 2 at P1- and P2-purinoceptors: supporting evidence fro purinergic innervation of the rabbit portal vein

1987 • 51 citations

The human P2X4 receptor gene is alternatively spliced

1998 • 49 citations

Identification of a P2X1Purinoceptor Expressed on Human Platelets

1998 • 48 citations

Acidosis reduces neuronal apoptosis

1998 • 48 citations

Properties of ATP-gated channels recorded from rat sympathetic neurons: voltage dependence and regulation by Zn2+ ions

1995 • 45 citations

The selective P2X purinoceptor agonist, ?,?-methylene-L-adenosine 5?-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors

1995 • 45 citations

L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli

1985 • 43 citations

Radiolabeling of the rat P2X4 purinoceptor: evidence for allosteric interactions of purinoceptor antagonists and monovalent cations with P2X purinoceptors.

1997 • 39 citations

Adenosine 5′-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle

1988 • 38 citations

A comparison of the binding characteristics of recombinant P_2×1 and P_2×2 purinoceptors

1996 • 36 citations

Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron

1996 • 35 citations

Reactive red 2: a P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase

1995 • 33 citations

A role for calcineurin in the desensitization of the P2X3 receptor

1997 • 32 citations

Cu2+ potently enhances ATP-activated current in rat nodose ganglion neurons

1996 • 31 citations

Electrophysiological effects of ATP on brain neurones

1996 • 26 citations

P2X Purinoceptors in Postmortem Human Cerebral Arteries

1998 • 26 citations

ATP‐induced Secretion in PC12 Cells and Photoaffinity Labeling of Receptors

1993 • 25 citations

Transduction Mechanisms of P2Z Purinoceptors

2007 • 19 citations

Evidence that [³H]‐α,β‐methylene ATP may label an endothelial‐derived cell line 5′‐nucleotidase with high affinity

1995 • 16 citations

Zn2+ potentiates steady-state ATP activated currents in rat nodose ganglion neurons by increasing the burst duration of a 35 pS channel

1995 • 16 citations

P2X Receptors

1998 • 16 citations

Triphosphate, the key structure of the ATP molecule responsible for interaction with P2X-purinoceptors

1993 • 12 citations

Zn2+ modulation of ATP-responses at recombinant P2X receptors: dependence on extracellular pH

1997 • 11 citations

P2 Receptor Modeling and Identification of Ligand Binding Sites

1998 • 9 citations

Coexpression of mRNAs forP2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situhybridization and RT-PCR study. J Vasc Res. 1998 May-Jun;35(3):179-85. PubMedPMID: 9647332.

1998 • 1 citations