In vitro cleavage of the simian virus 40 early polyadenylation site adjacent to a required downstream TG sequence.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1984 • 561 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

Are U4 small nuclear ribonucleoproteins involved in polyadenylation?

1984 • 379 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Transcription and RNA processing by the DNA tumour viruses

1980 • 228 citations

Site-specific polyadenylation in a cell-free reaction

1984 • 223 citations

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

1986 • 192 citations

Splicing of adenovirus RNA in a cell-free transcription system.

1983 • 159 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro.

1986 • 147 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.

1984 • 131 citations

Post-transcriptional regulation of the chicken thymidine kinase gene

1984 • 123 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation.

1984 • 109 citations

Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.

1985 • 105 citations

Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysate

1983 • 94 citations

Growth-Dependent Expression of Dihydrofolate Reductase mRNA from Modular cDNA Genes

1983 • 91 citations

Identification of a Sequence Element on the 3′ Side of AAUAAA Which Is Necessary for Simian Virus 40 Late mRNA 3′-End Processing

1985 • 59 citations

Addition of poly(A) to nuclear RNA occurs soon after RNA synthesis.

1980 • 46 citations

Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes.

1983 • 37 citations