Thiol Oxidation Enforces Phosphatidylserine Externalization in Apoptosis-Sensitive and -Resistant Cells Through a Δψm/Cytochrome c Release-Dependent Mechanism

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1991 • 1,017 citations

Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

2001 • 431 citations

Cellular thiols and reactive oxygen species in drug-induced apoptosis.

2001 • 341 citations

Mitochondria, oxygen free radicals, and apoptosis

2001 • 300 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis

2002 • 260 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Phosphatidylserine Exposure during Apoptosis Is a Cell-Type-Specific Event and Does Not Correlate with Plasma Membrane Phospholipid Scramblase Expression

1999 • 151 citations

Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells

1999 • 124 citations

Mitochondrial redox signaling during apoptosis.

1999 • 107 citations

Phosphatidylserine exposure in Fas type I cells is mitochondria‐dependent

2003 • 25 citations

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