Rat Metallothionein-1 Structural Gene and Three Pseudogenes, One of which Contains 5′-Regulatory Sequences

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

1978 • 1,117 citations

Promoter Sequences of Eukaryotic Protein-Coding Genes

1980 • 971 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

On the formation of spontaneous deletions: The importance of short sequence homologies in the generation of large deletions

1982 • 690 citations

A mew computer method for the storage and manipulation of DNA gel reading data

1980 • 679 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.

1982 • 625 citations

Atlas of Protein Sequence and Structure 1969

1970 • 623 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Pseudogenes as a paradigm of neutral evolution

1981 • 526 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements

1981 • 478 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

A history of the human fetal globin gene duplication

1981 • 349 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.

1983 • 314 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.

1982 • 279 citations

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence

1984 • 272 citations

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

1985 • 271 citations

Improvements of DNA sequencing gels

1981 • 269 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

RNA-Mediated Gene Duplication: the Rat Preproinsulin I Gene Is a Functional Retroposon

1985 • 256 citations

Los Alamos sequence analysis package for nucleic acids and proteins

1982 • 233 citations

Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNA

1984 • 195 citations

Evolution of Genetic Systems

1973 • 186 citations

Preparation and properties of the major copper-binding component in human fetal liver. Its identification as metallothionein.

1978 • 169 citations

Involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection.

1978 • 168 citations

Zinc accumulation and metabolism in primary cultures of adult rat liver cells. Regulation by glucocorticoids

1978 • 167 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.

1984 • 167 citations

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

1984 • 153 citations

Dexamethasone Stimulation of Metallothionein Synthesis in HeLa Cell Cultures

1979 • 131 citations

Rapidly evolving mouse alpha-globin-related pseudo gene and its evolutionary history.

1981 • 131 citations

Regulation of liver metallothionein and plasma zinc by the glucocorticoid dexamethasone

1979 • 130 citations

The ontogeny of expression of murine metallothionein: Comparison with the α-fetoprotein gene

1984 • 127 citations

Alternatives for splicing: Recognizing the ends of introns

1980 • 113 citations

Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers.

1984 • 112 citations

Molecular structures of human argininosuccinate synthetase pseudogenes. Evolutionary and mechanistic implications.

1984 • 72 citations

Molecular Cloning of the Rat Metallothionein 1 (MT-1) mRNA Sequence

1983 • 71 citations

Magic Enhancers?

1984 • 70 citations

Turnover of metallothioneins in rat liver

1978 • 70 citations

Levels of Metallothionein Messenger RNA in Foetal, Neonatal and Maternal Rat Liver

1983 • 60 citations

Nucleotide triphosphate utilization by cardiac and skeletal muscle sarcoplasmic reticulum. Evidence for a hydrolysis cycle not coupled to intermediate acyl phosphate formation and calcium translocation.

1981 • 52 citations

Metallothionein Synthesis in Foetal, Neonatal and Maternal Rat Liver

1983 • 42 citations

Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells

1980 • 40 citations

Metallothionein II. Proceedings of the "Second International Meeting on Metallothionein and Other Low Molecular Weight Metal-binding Proteins". Zürich, August 21-24, 1985.

1987 • 31 citations

Change in repeated DNA in evolution.

1972 • 30 citations

A 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Nonproliferative Variant of 3T3 Cells Is Resistant to TPA-Enhanced Gene Amplification

1985 • 16 citations