Endothelin Peptides and the Kidney

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

1989 • 496 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelins: multifunctional renal peptides.

1993 • 306 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs

1988 • 279 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Endothelin mediates the renal vasoconstriction induced by cyclosporine in the rat.

1990 • 176 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Endothelin inhibits renin release from isolated rat glomeruli

1988 • 165 citations

Endothelin-1 mRNA is widely expressed in porcine and human tissues.

1990 • 164 citations

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells

1992 • 163 citations

Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion.

1989 • 160 citations

Heterogeneity of cell surface endothelin receptors.

1990 • 159 citations

Increased renal endothelin production in rats with reduced renal mass

1991 • 154 citations

Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols

1989 • 154 citations

Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat.

1990 • 127 citations

Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.

1990 • 113 citations

Tissue specific distribution, clearance and vascular effects of endothelin in the pig

1989 • 110 citations

Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.

1991 • 109 citations

Production of endothelin-1 by rat cultured mesangial cells

1990 • 108 citations

Upregulation of renal endothelin receptors in rats with cyclosporine A-induced nephrotoxicity

1990 • 100 citations

Synthesis of the vasoconstrictor peptide endothelin in kidney cells

1989 • 99 citations

Endothelin stimulates atrial natriuretic peptide (ANP) release from rat atria

1988 • 87 citations

Endothelin-induced CA-independent contraction of the porcine coronary artery

1989 • 86 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Secretion of endothelin and related peptides from renal epithelial cell lines

1989 • 79 citations

Localization of endothelin-like immunoreactivity in rat kidneys

1991 • 78 citations

Endothelin stimulates PDGF secretion in cultured human mesangial cells

1990 • 76 citations

The Evolution of Peptide Hormones

1982 • 71 citations

Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.

1990 • 69 citations

Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells

1990 • 67 citations

The molecular mechanisms of cardiovascular and renal regulation by endothelin peptides.

1992 • 66 citations

Endothelins: a family of regulatory peptides. State-of-the-art lecture.

1991 • 65 citations

High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells

1989 • 65 citations

Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells

1991 • 63 citations

Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products.

1991 • 63 citations

Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.

1991 • 58 citations

Endothelin: isoforms, binding sites and possible implications in pathology

1990 • 57 citations

Renal effects and mesangial cell contraction induced by endothelin are mediated by PAF

1991 • 57 citations

Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats.

1989 • 55 citations

Effects of endothelin on in vitro renin secretion

1991 • 51 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1993 • 50 citations

Renal actions of endothelin: interaction with prostacyclin

1990 • 45 citations

Control of the renal microvasculature by vasoactive peptides ¹

1990 • 39 citations

Endothelin binding and receptor down regulation in rat glomerular mesangial cells.

1991 • 38 citations

Positive inotropic action, natriuresis and atrial natriuretic factor release induced by endothelin in the conscious rat

1990 • 35 citations

Similar distribution of [125I]sarafotoxin-6b and [125I]endothelin-1, -2, -3 binding sites in the human kidney

1990 • 34 citations

Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

1989 • 34 citations

Inhibitory effect of endothelin on renin release in vitro

1989 • 34 citations

Hemodynamic and tubular effects of endothelin and thromboxane in the isolated perfused rat kidney

1989 • 33 citations

Effects of endothelin on renal regional blood flow in dogs

1989 • 33 citations

Cyclooxygenase products and atrial natriuretic peptide modulate renal response to endothelin.

1990 • 23 citations

Natiuretic and Diuretic Effects of Endothelin in Isolated Perfused Rat Kidney.

1989 • 8 citations

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