Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System

The chemical basis of morphogenesis

1952 • 11,233 citations

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

1998 • 1,565 citations

Hedgehog signalling in the mouse requires intraflagellar transport proteins

2003 • 1,377 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Pattern formation by local self-activation and lateral inhibition

2000 • 611 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut

2005 • 602 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Establishment of vertebrate left–right asymmetry

2002 • 530 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination

2005 • 466 citations

Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus

1996 • 459 citations

Left–right asymmetry in embryonic development: a comprehensive review

2004 • 447 citations

Abnormal Nodal Flow Precedes Situs Inversus in iv and inv mice

1999 • 421 citations

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination

2000 • 420 citations

Argosomes

2001 • 413 citations

The zebrafish Nodal signal Squint functions as a morphogen

2001 • 328 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

2004 • 283 citations

Nodal activity in the node governs left-right asymmetry

2002 • 281 citations

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

1998 • 241 citations

Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2

2000 • 236 citations

Embryonic Dorsal-Ventral Signaling: Secreted Frizzled-Related Proteins as Inhibitors of Tolloid Proteinases

2006 • 221 citations

Two-Step Regulation of Left–Right Asymmetric Expression of Pitx2

2001 • 214 citations

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion

2002 • 197 citations

Role of Notochord in Specification of Cardiac Left–Right Orientation in Zebrafish andXenopus

1996 • 197 citations

Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal Signaling

2002 • 162 citations

Left–right patterning of the mouse lateral plate requires nodal produced in the node

2003 • 132 citations

Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2

2001 • 130 citations

Zebrafish Leopard gene as a component of the putative reaction-diffusion system

1999 • 128 citations

The reaction‐diffusion system: a mechanism for autonomous pattern formation in the animal skin

2002 • 110 citations

Nodal signaling induces the midline barrier by activatingNodalexpression in the lateral plate

2003 • 104 citations

Roles of nodal‐lefty regulatory loops in embryonic patterning of vertebrates

2001 • 90 citations

Organizer and axes formation as a self-organizing process.

2001 • 86 citations

Do we know anything about how left–right asymmetry is first established in the vertebrate embryo?

2005 • 66 citations

Two nodal‐responsive enhancers control left–right asymmetric expression of Nodal

2005 • 34 citations

Identification of a novel left–right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily

2004 • 19 citations