Loss of CD4⁺T Cells in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Is Associated with Increased Lymphocyte Apoptosis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Quantitation of HIV-1 RNA in Plasma Predicts Outcome after Seroconversion

1995 • 922 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

1996 • 499 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

1995 • 386 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry

1994 • 319 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections.

1994 • 250 citations

Macrophage-dependent Apoptosis of CD4+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor

1997 • 242 citations

Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1

1997 • 206 citations

Evidence for rapid disappearance of initially expanded HIV-specific CD8⁺T cell clones during primary HIV infection

1997 • 201 citations

Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells

1997 • 194 citations

Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection.

1996 • 161 citations

Pathogenic diversity of simian immunodeficiency viruses

1994 • 153 citations

Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

1994 • 152 citations

AIDS as immune system activation: a model for pathogenesis.

1988 • 129 citations

Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype.

1997 • 123 citations

Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method

1994 • 117 citations

Lack of T Cell Dysfunction and Programmed Cell Death in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Correlates with Absence of Monocytotropic Variants

1993 • 105 citations

Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection

1995 • 93 citations

HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells.

1994 • 87 citations

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication

1997 • 85 citations

Superinfection of a chimpanzee with a second strain of human immunodeficiency virus

1987 • 82 citations

A chimpanzee-passaged human immunodeficiency virus isolate is cytopathic for chimpanzee cells but does not induce disease

1991 • 79 citations

Role of apoptosis in HIV disease pathogenesis

1995 • 79 citations

Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule.

1997 • 75 citations

The resistance of HIV‐infected chimpanzees to progression to AIDS correlates with absence of HIV‐related T‐cell dysfunction

1993 • 74 citations

Immunohistopathology of lymph nodes in HTLV-III infected homosexuals with persistent adenopathy or AIDS.

1985 • 68 citations

Nonhuman Primate Models for AIDS

1993 • 66 citations

Transient Increases in Numbers of Infectious Cells in an HIV-infected Chimpanzee Following Immune Stimulation

1992 • 55 citations

Long-Term Observations of Human Immunodeficiency Virus-Infected Chimpanzees

1993 • 50 citations

Extensive Diversification of Human Immunodeficiency Virus Type 1 Subtype B Strains during Dual Infection of a Chimpanzee That Progressed to AIDS

1998 • 46 citations

Prolonged CD4+ Lymphocytopenia and Thrombocytopenia in a Chimpanzee Persistently Infected with Human Immunodeficiency Virus Type 1

1991 • 45 citations

Apoptosis-Related Mortality in Vitro of Mononuclear Cells from Patients with HIV Infection Correlates with Disease Severity and Progression

1995 • 42 citations

The inability of human immunodeficiency virus to infect chimpanzee monocytes can be overcome by serial viral passage in vivo

1991 • 41 citations

HIV-2 EHO Isolate Has a Divergent Envelope Gene and Induces Single Cell Killing by Apoptosis

1994 • 38 citations

Frequency of Provirus-Bearing CD4⁺Cells in HIV Type 1 Infection Correlates with Extent ofin VitroApoptosis of CD8⁺but Not of CD4⁺Cells

1995 • 31 citations

Impairment in T-lymphocyte responses during early infection with the human immunodeficiency virus

1989 • 29 citations

Immune and hematopoietic parameters in HIV‐1‐infected chimpanzees during clinical progression toward AIDS

1997 • 25 citations

Apoptosis in HIV-Infected Individuals Is an Early Marker Occurring Independently of High Viremia

1997 • 24 citations

Apoptosis-Related Mortality in Vitro of Mononuclear Cells from Patients with HIV Infection Correlates with Disease Severity and Progression

1995 • 23 citations

From Cell Activation to Cell Depletion

1995 • 22 citations

Cell Activation and Apoptosis in HIV Infection

1995 • 15 citations