Differential distribution of protein kinase C isozymes in the various regions of brain.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Neurobiology of learning and memory

1985 • 1,024 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples.

1981 • 815 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Chemical Anatomy of the Brain

1984 • 411 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.

1985 • 361 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell

1986 • 268 citations

Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding

1986 • 267 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells

1986 • 233 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

Distinct patterns of expression of different protein kinase C mRNAs in rat tissues

1987 • 227 citations

Two types of complementary DNAs of rat brain protein kinase C

1986 • 212 citations

Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 183 citations

Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.

1987 • 156 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

Cloning of rat brain protein kinase C complementary DNA

1986 • 124 citations

A rapid and sensitive assay method for protein kinase

1976 • 121 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

Immunochemical characterization of rat brain protein kinase C.

1986 • 110 citations

Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester

1984 • 109 citations

Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsim

1986 • 74 citations

Redistribution of protein kinase C during mitogenesis of human B lymphocytes

1986 • 68 citations

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

1986 • 62 citations

Formation of a phorbol ester-binding fragment from protein kinase C by proteolytic digestion.

1986 • 61 citations