A New Orphan Receptor Involved in Pulsatile Growth Hormone Release

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly

1982 • 1,263 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour

1982 • 1,092 citations

Peptidomimetic Regulation of Growth Hormone Secretion

1997 • 520 citations

A Nonpeptidyl Growth Hormone Secretagogue

1993 • 345 citations

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors

1997 • 341 citations

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

1995 • 323 citations

The Synergistic Effects of His-D-Trp-Ala-Trp-D-Phe- Lys-NH₂on Growth Hormone (GH)-Releasing Factor- Stimulated GH Release and Intracellular Adenosine 3',5'-Monophosphate Accumulation in Rat Primary Pituitary Cell Culture

1989 • 298 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6*

1997 • 285 citations

Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.

1993 • 272 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

1996 • 256 citations

Design, Synthesis, and Biological Activity of Peptides which Release Growth Hormone in Vitro*

1981 • 210 citations

Identification of a new G-protein-linked receptor for growth hormone secretagogues.

1996 • 199 citations

Hypothalamic Growth Hormone Secretagogue-Receptor (GHS-R) Expression Is Regulated by Growth Hormone in the Rat

1997 • 190 citations

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level.

1995 • 189 citations

Growth Hormone Releasing Peptides

1996 • 188 citations

Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons

1993 • 182 citations

Peptidomimetic Regulation of Growth Hormone Secretion

1997 • 164 citations

Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure¹

1998 • 163 citations

Somatostatin Receptor Subtype 2 Knockout Mice Are Refractory to Growth Hormone-Negative Feedback on Arcuate Neurons

1997 • 162 citations

Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus

1998 • 155 citations

Identification of a new G-protein-linked receptor for growth hormone secretagogues

1996 • 131 citations

Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues

1998 • 124 citations

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

1996 • 120 citations

Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

1998 • 115 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

1996 • 109 citations

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors

1997 • 103 citations

Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585

1996 • 101 citations

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6

1997 • 93 citations

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism1

1998 • 91 citations

Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by two mechanisms.

1994 • 90 citations

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level

1995 • 79 citations

Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.

1995 • 75 citations

Central Administration of a Growth Hormone (GH) Receptor mRNA Antisense Increases GH Pulsatility and Decreases Hypothalamic Somatostatin Expression in Rats

1996 • 74 citations

Peptidomimetic Growth Hormone Secretagogues. Design Considerations and Therapeutic Potential

1998 • 69 citations

Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults¹

1997 • 64 citations

The Growth Hormone Secretagogue, L-692,429, Induces Phosphatidylinositol Hydrolysis and Hormone Secretion by Human Pituitary Tumors

1995 • 58 citations

Somatostatin Receptor Subtype 2 Knockout Mice Are Refractory to Growth Hormone-Negative Feedback on Arcuate Neurons

1997 • 54 citations

Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults--a clinical research center study.

1996 • 54 citations

Hypothalamic Growth Hormone Secretagogue-Receptor (GHS-R) Expression Is Regulated by Growth Hormone in the Rat

1997 • 53 citations

Growth Hormone Secretagogues in Clinical Practice

1998 • 51 citations

Development of a High Specific Activity Sulfur-35-Labeled Sulfonamide Radioligand That Allowed the Identification of a New Growth Hormone Secretagogue Receptor

1996 • 50 citations

Growth Hormone Secretagogues

1996 • 49 citations

Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus

1998 • 47 citations

Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

1997 • 46 citations

A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue

1998 • 44 citations

GHRP-6 induces a biphasic calcium response in rat pituitary somatotrophs

1994 • 43 citations

Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues

1997 • 42 citations

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

1998 • 42 citations

Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by two mechanisms

1994 • 40 citations

1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540): A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue

1998 • 35 citations

Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults--a clinical research center study

1996 • 31 citations

Xenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides

1996 • 30 citations

Endogenous Growth Hormone (GH) Secretion in Male Rats Is Synchronized to Pulsatile GH Infusions Given at 3-Hour Intervals*

1990 • 30 citations

The Nonpeptide Growth Hormone Secretagogue, MK‐0677, Activates Hypothalamic Arcuate Nucleus Neurons in vivo

1998 • 26 citations

Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and non-peptide secretagogues

1998 • 15 citations

Growth Hormone Secretagogues in Clinical Practice

1998 • 4 citations