Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation.

1990 • 1,515 citations

Improved technique of heart transplantation in rats

1969 • 1,338 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Ras and Rho GTPases

2000 • 779 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

2000 • 619 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Immunosuppressive strategies in transplantation

1999 • 461 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

2001 • 443 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection

2000 • 255 citations

Differential Requirements for DOCK2 and Phosphoinositide-3-Kinase γ during T and B Lymphocyte Homing

2004 • 224 citations

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

2001 • 222 citations

The expanding world of co-stimulation: the two-signal model revisited

2001 • 214 citations

Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28−/− mice

2001 • 202 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

1998 • 185 citations

Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice

1998 • 178 citations

Chemokines and their receptors in allograft rejection

2000 • 177 citations

Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection

2001 • 167 citations

Chemokines: directing leukocyte infiltration into allografts

2002 • 150 citations

The International Society for Heart Transplantation

1982 • 148 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Deficiency of Small Gtpase Rac2 Affects T Cell Activation

2001 • 117 citations

CD28-independent Costimulation of T Cells in Alloimmune Responses

2001 • 117 citations

DOCK2 Is Essential for Antigen-Induced Translocation of TCR and Lipid Rafts, but Not PKC-θ and LFA-1, in T Cells

2003 • 116 citations

ACUTE REJECTION OF VASCULARIZED HEART ALLOGRAFTS IN THE ABSENCE OF IFN??1,2

1996 • 112 citations

Cells Mediating Allograft Rejection

1984 • 94 citations

CELL ADHESION MOLECULES IN CLINICAL RENAL TRANSPLANTATION1

1998 • 94 citations

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

2001 • 86 citations

Perforin-Mediated Effector Function Within the Central Nervous System Requires IFN-γ-Mediated MHC Up-Regulation

2003 • 85 citations

Heterologous immunity and homeostatic proliferation as barriers to tolerance

2004 • 75 citations

Routes to Transplant Tolerance versus Rejection

2004 • 73 citations

Chemokines, their receptors, and transplant outcome1

2002 • 64 citations

Secondary Lymphoid Organs Are Important But Not Absolutely Required for Allograft Responses

2003 • 62 citations

PROLONGATION OF ALLOGRAFT SURVIVAL IN CCR7-DEFICIENT MICE

2004 • 42 citations

ISLET REJECTION IN PERFORIN-DEFICIENT MICE

1997 • 38 citations

Enforced c-REL deficiency prolongs survival of islet allografts1

2002 • 33 citations

INTERLEUKIN-2 AND INTERFERON-?? DOUBLE KNOCKOUT MICE REJECT HETEROTOPIC CARDIAC ALLOGRAFTS

2000 • 26 citations

Targeting proximal T cell receptor signaling in transplantation

2003 • 6 citations