Stunning: Damaging or protective to the myocardium?

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

Reversibility of Cardiac Wall-Motion Abnormalities Predicted by Positron Tomography

1986 • 1,306 citations

Mechanism of myocardial "stunning".

1990 • 995 citations

Reversible ischemic left ventricular dysfunction: Evidence for the “hibernating myocardium”

1986 • 733 citations

A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina.

1985 • 589 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

A Randomized Trial of Intracoronary Streptokinase in the Treatment of Acute Myocardial Infarction

1983 • 536 citations

Kinetics of calcium accumulation in acute myocardial ischemic injury.

1972 • 507 citations

Reperfusion of the ischemic myocardium

1977 • 469 citations

Studies of experimental coronary artery reperfusion. Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage.

1983 • 363 citations

Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI).

1986 • 332 citations

Nitroglycerin to Unmask Reversible Asynergy Correlation with Post Coronary Bypass Ventriculography

1974 • 323 citations

Influence of Direct Myocardial Revascularization on Left Ventricular Asynergy and Function in Patients with Coronary Heart Disease

1973 • 294 citations

Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation

1986 • 279 citations

Exercise echocardiography: A clinically practical addition in the evaluation of coronary artery disease

1983 • 268 citations

Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.

1984 • 265 citations

The time of onset and severity of acidosis in myocardial ischaemia

1980 • 249 citations

Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina.

1986 • 238 citations

Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.

1983 • 231 citations

Immediate improvement of dysfunctional myocardial segments after coronary revascularization: Detection by intraoperative transesophageal echocardiography

1984 • 226 citations

Time course and determinants of recovery of function after reversible ischemia in conscious dogs

1988 • 218 citations

Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration

1985 • 215 citations

Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation

1984 • 210 citations

Postextrasystolic Potentiation as a Predictor of Potential Myocardial Viability: Preoperative Analyses Compared With Studies After Coronary Bypass Surgery

1977 • 198 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Altered myocardial states

1989 • 187 citations

Some unexpected lessons from large multicenter randomized clinical trials.

1985 • 187 citations

Augmentation of Left Ventricular Contraction Pattern in Coronary Artery Disease by an Inotropic Catecholamine

1974 • 184 citations

Studies of controlled reperfusion after ischemia

1990 • 181 citations

Identification of transient and persistent segmental wall motion abnormalities in patients with unstable angina by two-dimensional echocardiography.

1982 • 180 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Improved regional ventricular function after successful surgical revascularization

1984 • 176 citations

Preoperative Prediction of Reversible Myocardial Asynergy by Postexercise Radionuclide Ventriculography

1982 • 168 citations

Depression of Left Ventricular Function Due to Acute Myocardial Ischemia and Its Reversal after Aortocoronary Saphenous-Vein Bypass

1972 • 161 citations

Selective enhancement of function of stunned myocardium by increased flow.

1986 • 160 citations

Effect of verapamil on postischemic “stunned” myocardium: Importance of the timing of treatment

1988 • 160 citations

STUDIES OF CONTROLLED REPERFUSION AFTER ISCHEMIA

1986 • 154 citations

Coronary artery reperfusion in acute myocardial infarction: Beneficial effects of intracoronary streptokinase on left ventricular salvage and performance

1981 • 149 citations

Myocardial recovery during post-ischaemic reperfusion: Effects of nifedipine, calcium and magnesium

1986 • 146 citations

The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction

1987 • 133 citations

Inotropic stimulation of reperfused myocardium with dopamine: Effects on infarct size and myocardial function

1985 • 124 citations

Ischemia, reperfusion, and the determinants of tissue injury

1990 • 123 citations

Nifedipine administered after reperfusion ablates systolic contractile dysfunction of postischemic “stunned” myocardium

1989 • 98 citations

Determinants of Reversible Asynergy

1974 • 91 citations

Calcium, strontium, and barium movements during ischemia and reperfusion in rabbit ventricle. Implications for myocardial preservation.

1978 • 89 citations

Response of the left ventricle in coronary artery disease to postextrasystolic potentiation.

1975 • 81 citations

Nonuniform transmural recovery of contractile function in stunned myocardium

1989 • 79 citations

Studies on prolonged acute regional ischemia

1989 • 76 citations

Coronary vasospasm as a cause of stunned myocardium

1987 • 60 citations

Optimal calcium concentration in the initial reperfusate for post-ischemic myocardial performance (calcium concentration during reperfusion)

1986 • 56 citations

Analysis of reported randomized trials of streptokinase therapy for acute myocardial infarction in the 1980s

1987 • 48 citations

Effect of oxygen-derived free radical scavengers on infarct size following six hours of permanent coronary artery occlusion: salvage or delay of myocyte necrosis?

1987 • 48 citations

The assessment of contractile reserve after thrombolytic therapy for acute myocardial infarction

1986 • 46 citations

Effects of temperature on myocardial calcium homeostasis and mitochondrial function during ischemia and reperfusion

1990 • 36 citations

Effect of D-600 on ischemic and reperfused rabbit myocardium: relation with timing and modality of administration

1989 • 32 citations

Superoxide dismutase: Possible therapeutic use in cardiovascular disease

1989 • 29 citations

Is “stunned myocardium” a protective mechanism? Effect of acute recruitment and acute β-blockade on recovery of contractile function and high-energy phosphate stores at 1 day post-reperfusion

1989 • 24 citations

Changes in Glycolysis and in High-Energy Phosphates During Myocardial Ischemia with Intermittent Coronary Perfusion

1971 • 23 citations

Studies on prolonged acute regional ischemia. II. Implications of progression from dyskinesia to akinesia in the ischemic segment.

1989 • 22 citations

Left ventricular bands (false tendons): Echocardiographic and angiocardiographic delineation in children

1986 • 21 citations

Reversal of rest myocardial asynergy during exercise: A radionuclide scintigraphic study

1985 • 14 citations

Studies on prolonged acute regional ischemia

1989 • 14 citations

Importance of early recanalization of the occluded coronary artery in acute myocardial infarction for preservation of left ventricular function

1988 • 11 citations

Dynamic ventriculography with K-strophantin.

1978 • 7 citations