Ischemia, reperfusion, and the determinants of tissue injury

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog.

1960 • 762 citations

Reversible ischemic left ventricular dysfunction: Evidence for the “hibernating myocardium”

1986 • 733 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Reperfusion-induced arrhythmias: Mechanisms and prevention

1984 • 574 citations

Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts.

1984 • 572 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Reperfusion of the ischemic myocardium

1977 • 469 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with "anti-free radical" interventions and a free radical-generating system in the isolated perfused rat heart.

1986 • 396 citations

Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats.

1980 • 377 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs

1981 • 359 citations

Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)

1988 • 349 citations

Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias

1987 • 339 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Myocardial ischemia revisited. The osmolar load, membrane damage, and reperfusion

1986 • 313 citations

Reperfusion arrhythmia: A marker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction

1983 • 277 citations

Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.

1984 • 265 citations

Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.

1986 • 242 citations

Protection of the Ischemic Myocardium: Cardioplegia

1982 • 227 citations

Time course and determinants of recovery of function after reversible ischemia in conscious dogs

1988 • 218 citations

Myocardial consequences of reperfusion

1987 • 212 citations

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 • 205 citations

Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release

1976 • 177 citations

Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.

1987 • 168 citations

Protection of the Ischemic Myocardium: Cardioplegia

1981 • 166 citations

Cyclic AMP levels in ischaemic and non-ischaemic myocardium following coronary artery ligation: Relation to ventricular fibrillation

1978 • 147 citations

Oxygen-induced enzyme release: Early events and a proposed mechanism

1979 • 120 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

Abnormal electrical activity induced by free radical generating systems in isolated cardiocytes

1988 • 112 citations

Free radicals and calcium: Simultaneous interacting triggers as determinants of vulnerability to reperfusion-induced arrhythmias in the rat heart

1988 • 112 citations

Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias.

1987 • 109 citations

Ventricular fibrillation caused by myocardial reperfusion in Prinzmetal's angina

1983 • 103 citations

Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel.

1991 • 101 citations

Rapid electrophysiological changes leading to arrhythmias in the aerobic rat heart. Photosensitization studies with rose bengal-derived reactive oxygen intermediates.

1989 • 79 citations

Singlet oxygen and myocardial injury: Ultrastructural, cytochemical and electrocardiographic consequences of photoactivation of rose bengal

1990 • 73 citations

Life-Threatening arrhythmias during ischemia and infarction

1988 • 65 citations

Singlet oxygen-induced arrhythmias. Dose- and light-response studies for photoactivation of rose bengal in the rat heart.

1989 • 60 citations

Can beta blockers limit myocardial infarct size?

1986 • 52 citations

Circadian Blood Pressure Variations and Their Impact on Disease

1988 • 50 citations

The protection of the ischemic myocardium: Surgical success v clinical failure?

1988 • 44 citations

Life-threatening arrhythmias during ischemia and infarction

1987 • 37 citations

Microbiopsy metabolite and paired flow analysis: a new rapid procedure for homogenisation, extraction and analysis of high energy phosphates and other intermediates without any errors from tissue loss

1984 • 37 citations

Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

1989 • 34 citations

Circadian patterns of myocardial ischemia

1989 • 30 citations

Reperfusion-induced arrhythmias in the isolated rabbit heart: Characterization of the influence of the duration of regional ischemia and the extracellular potassium concentration

1988 • 27 citations

Early Arrhythmias, Myocardial Extracellular Potassium and pH

1982 • 19 citations

Circadian Patterns of Myocardial Ischemia

1988 • 17 citations

Synthesis of cardiac glycogen in relation to its 24-hr rhythm in rats

1971 • 15 citations

Ischemia at the crossroads?

1988 • 13 citations

Free Radicals and Myocardial Injury during Ischemia and Reperfusion: A Short-Lived Phenomenon?

1989 • 12 citations

The sarcolemma in low-flow and total ischemia of canine left ventricle

1986 • 5 citations

Diagnosis of myocardial ischemia in man. Concluding remarks: the "stunned" cardiologist.

1986 • 4 citations