Presynaptic Dopaminergic Dysfunction in Schizophrenia

Conflict monitoring and cognitive control.

2001 • 6,590 citations

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1987 • 3,683 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

The cognitive neuropsychology of schizophrenia

1993 • 1,847 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations

1985 • 1,604 citations

Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia.

1992 • 1,477 citations

The neuropsychology of schizophrenia

1991 • 1,376 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Three‐dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe

2003 • 1,156 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Measurement in Neurological Rehabilitation

1993 • 1,023 citations

Increased baseline occupancy of D ₂ receptors by dopamine in schizophrenia

2000 • 996 citations

Imaging Synaptic Neurotransmission within VivoBinding Competition Techniques: A Critical Review

2000 • 938 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

D1 receptors in prefrontal cells and circuits

2000 • 804 citations

Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort

1998 • 786 citations

Prefrontal Dopamine D₁Receptors and Working Memory in Schizophrenia

2002 • 724 citations

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

1997 • 707 citations

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

2002 • 640 citations

Differing patterns of striatal ¹⁸F‐dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy

1990 • 614 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D₂ Receptor Parameter Measurements in Ventral Striatum

2001 • 530 citations

Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function

1999 • 507 citations

Catecholamine regulation of the prefrontal cortex

1997 • 478 citations

Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

1999 • 452 citations

Anterior Cingulate Gyrus Dysfunction and Selective Attention Deficits in Schizophrenia: [¹⁵O]H₂O PET Study During Single-Trial Stroop Task Performance

1997 • 398 citations

Anterior Cingulate Cortex and Response Conflict: Effects of Response Modality and Processing Domain

2001 • 356 citations

Elevated dopa decarboxylase activity in living brain of patients with psychosis.

1994 • 335 citations

Human positron emission tomographic [¹⁸F]Fluorodopa studies correlate with dopamine cell counts and levels

1993 • 331 citations

SPECT imaging of striatal dopamine release after amphetamine challenge.

1995 • 330 citations

Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients

1995 • 323 citations

Neurotransmitter interactions in schizophrenia—therapeutic implications

1999 • 305 citations

Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(β-11C) DOPA and PET

1999 • 286 citations

Imaging dopamine transmission in schizophrenia. A review and meta-analysis.

1998 • 281 citations

Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia

1999 • 243 citations

Dysfunctions in Multiple Interrelated Systems as the Neurobiological Bases of Schizophrenic Symptom Clusters

1998 • 198 citations

PET Study of D₁ Dopamine Receptor Binding in Neuroleptic-Naive Patients With Schizophrenia

2002 • 170 citations

Correlation of striatal fluorodopa uptake in the MPTP Monkey with dopaminergic indices

1993 • 168 citations

High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers

2000 • 165 citations

Presynaptic dopaminergic function in the striatum of schizophrenic patients

1997 • 163 citations

Physical characteristics of the ECAT EXACT3D positron tomograph

2000 • 156 citations

Clustering and switching strategies in verbal fluency tasks: Comparison between schizophrenics and healthy adults

1998 • 154 citations

Regional changes in [¹⁸F]dopa metabolism in the striatum in Parkinson's disease

1996 • 145 citations

Endogenous dopamine release after pharmacological challenges in Parkinson's disease

2003 • 145 citations

The Stroop task and attention deficits in schizophrenia: A critical evaluation of card and single-trial Stroop methodologies.

1998 • 136 citations

Dopamine D2 densities and the schizophrenic brain

1998 • 119 citations

Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms

1998 • 113 citations

Regulation of Aromatic <scp>l</scp>‐Amino Acid Decarboxylase by Dopamine Receptors in the Rat Brain

1992 • 112 citations

Subchronic Haloperidol Downregulates Dopamine Synthesis Capacity in the Brain of Schizophrenic Patients In Vivo

2002 • 106 citations

6-18F-DOPA PET study in patients with schizophrenia

2000 • 101 citations

The effect of entacapone (OR‐611) on brain [ ¹⁸ F]‐6‐L‐fluorodopa metabolism

1994 • 99 citations

Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: Anin vivo neurochemical assessment in the rhesus monkey

1995 • 93 citations

FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa

1999 • 86 citations

Input functions for 6-[fluorine-18]fluorodopa quantitation in parkinsonism: comparative studies and clinical correlations.

1994 • 83 citations

Regulation of striatal aromatic L-amino acid decarboxylase: Effects of blockade or activation of dopamine receptors

1993 • 79 citations

Anterior Cingulate Metabolism Correlates with Stroop Errors in Paranoid Schizophrenia Patients

2001 • 69 citations

Regulation of tyrosine hydroxylase and aromatic l-amino acid decarboxylase by dopaminergic drugs

1997 • 65 citations

The nature of interactions involving prefrontal and striatal dopamine systems

1997 • 54 citations

Fluorodopa Positron Emission Tomography with an Inhibitor of Catechol-O-Methyltransferase: Effect of the Plasma 3-O-Methyldopa Fraction on Data Analysis

1996 • 53 citations

In Vivo Regulation of DOPA Decarboxylase by Dopamine Receptors in Rat Brain

1997 • 52 citations

Effect of apomorphine infusion on dopamine synthesis rate relates to dopaminergic tone

1998 • 38 citations

Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo

2001 • 33 citations

Quantification of Neuroreceptors in Living Human Brain. V. Endogenous Neurotransmitter Inhibition of Haloperidol Binding in Psychosis

2001 • 29 citations

Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET

2000 • 25 citations