Tumor radiosensitization with concomitant vone marrow radioprotection: A study in mice using diethyldithiocarbamate (DDC) under oxygenated and hypoxic conditions

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

A New Mouse Tumor Model System (RIF-1) for Comparison of End-Point Studies<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 382 citations

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

1980 • 300 citations

Superoxide dismutase and glutathione peroxidase activities in tumors

1977 • 110 citations

Repair of potentially lethal lesions in x-irradiated, density-inhibited Chinese hamster cells: metabolic effects and hypoxia.

1973 • 86 citations

Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages.

1980 • 81 citations

Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its mechanisms of action

1983 • 70 citations

Clinical trials of WR-2721 with radiation therapy

1982 • 64 citations

Diethyldithiocarbamate Enhancement of Radiation and Hyperthermic Effects on Chinese Hamster Cells in Vitro

1979 • 58 citations

Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses

1979 • 56 citations

Repair of Potentially Lethal Lesions in X-Irradiated, Density-Inhibited Chinese Hamster Cells: Metabolic Effects and Hypoxia

1973 • 50 citations

Radioprotection of mouse skin by WR-2721: The critical influence of oxygen tension

1982 • 49 citations

Diethyldithiocarbamate, a superoxide dismutase inhibitor, decreases the radioresistance of Chinese hamster cells.

1980 • 49 citations

The treatment of acute nickel carbonyl poisoning with sodium diethyldithiocarbamate.

1971 • 41 citations

Modification of the bone marrow toxicity of cis-diamminedichloroplatinum(II) in mice by diethyldithiocarbamate.

1984 • 39 citations

Diethyldithiocarbamate, a Superoxide Dismutase Inhibitor, Decreases the Radioresistance of Chinese Hamster Cells

1980 • 39 citations

Low radioprotection by thiol in lung: the role of local tissue oxygenation

1983 • 33 citations

Phase I clinical trials of WR-2721 with alkylating agent chemotherapy

1982 • 28 citations

On the relative importance of hypoxic cells for the radiotherapy of human tumours

1974 • 25 citations

Modification of the sensitivity and repair of potentially lethal damage by diethyldithiocarbamate during and following exposure of plateau-phase cultures of mammalian cells to radiation and cis-diamminedichloroplatinum(II).

1982 • 24 citations

Colony-forming units and survival of irradiated mice treated with AET or endotoxin.

1969 • 22 citations

An in vivo study of the radioprotective effect of diethyldithiocarbamate (DDC)

1983 • 21 citations

Clinical trial of the effect of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) (NSC 296961) on the toxicity of cyclophosphamide.

1983 • 19 citations

Enhancement of heat sensitivity and modification of repair of potentially lethal heat damage in plateau-phase cultures of mammalian cells by diethyldithiocarbamate.

1983 • 18 citations

Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

1984 • 17 citations

Qualitative Alteration in Radiation Injury Under Hypoxic Conditions

1968 • 14 citations

Enhancement of Heat Sensitivity and Modification of Repair of Potentially Lethal Heat Damage in Plateau-Phase Cultures of Mammalian Cells by Diethyldithiocarbamate

1983 • 14 citations

Colony-Forming Units and Survival of Irradiated Mice Treated with AET or Endotoxin

1969 • 12 citations

Evaluation of diethyldithiocarbamate as a radioprotector of bone marrow

1984 • 11 citations

Combined Chemical and Hypoxic Protection against Whole-Body X-Irradiation in the Nestling Rat

1968 • 4 citations

In vivo radioprotection of normal tissues and a tumor by diethyldithiocarbamate (DDC)

1984 • 1 citations