Tocopherols and the Etiology of Colon Cancer

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Cancer statistics, 1997

1997 • 2,045 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

The causes and prevention of cancer.

1995 • 1,326 citations

Relation of Meat, Fat, and Fiber Intake to the Risk of Colon Cancer in a Prospective Study among Women

1990 • 1,258 citations

Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro

1981 • 1,071 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Reactions of oxyl radicals with DNA

1995 • 1,041 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma

1994 • 769 citations

Antioxidants in relation to lipid peroxidation

1987 • 684 citations

Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.

1993 • 591 citations

WOMEN AND MEN

1945 • 387 citations

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

1995 • 380 citations

Vitamin E: beyond antioxidant function

1995 • 371 citations

Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

1994 • 368 citations

Possible mutagens derived from lipids and lipid precursors

1990 • 340 citations

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

1993 • 337 citations

Free radicals and the etiology of colon cancer

1990 • 329 citations

Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins

1989 • 301 citations

d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

1995 • 290 citations

COMMENTARY: p⁵³ Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

1996 • 284 citations

Oral α-Tocopherol Supplements Decrease Plasma γ-Tocopherol Levels in Humans

1985 • 267 citations

Absorption, Transport and Distribution of Vitamin E

1990 • 265 citations

Reduced risk of colon cancer with high intake of vitamin E : the Iowa Women's Health Study.

1993 • 237 citations

Types of dietary fat and the incidence of cancer at five sites

1990 • 235 citations

Effect of phytyl side chain of vitamin E on its antioxidant activity.

1985 • 218 citations

A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps.

1988 • 204 citations

Purification and characterization of the α‐tocopherol transfer protein from rat liver

1991 • 199 citations

Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo

1995 • 196 citations

Dietary iron and colorectal cancer risk

1992 • 192 citations

Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.

1980 • 189 citations

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.

1986 • 183 citations

Lipid Peroxidation in Vivo during Vitamin E and Selenium Deficiency in the Rat as Monitored by Ethane Evolution

1977 • 175 citations

Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI chemoprevention drug development program

1994 • 172 citations

Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects

1993 • 168 citations

Epidemiologic evidence for vitamin C and vitamin E in cancer prevention

1995 • 165 citations

Absorption, Transport and Metabolism of Vitamin E

1991 • 160 citations

Recent hypotheses for the origin of colon cancer.

1987 • 158 citations

Rat liver α-tocopherol binding protein

1977 • 156 citations

Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins

1993 • 153 citations

Vitamin E: a sensor and an information transducer of the cell oxidation state

1995 • 142 citations

Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition1

1974 • 136 citations

Vitamin E and cancer prevention: recent advances and future potentials.

1992 • 132 citations

Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition

1974 • 129 citations

Determinants of plasma vitamin E concentrations

1994 • 129 citations

Role of the Gastrointestinal Mucosa and Microflora in the Bioactivation of Dietary and Environmental Mutagens or Carcinogens

1992 • 126 citations

Epidemiologic studies of antioxidants and cancer in humans.

1995 • 121 citations

Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes

1996 • 121 citations

In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids.

1984 • 116 citations

Biokinetics in humans of RRR-α-tocopherol: The free phenol, acetate ester, and succinate ester forms of vitamin E

1995 • 111 citations

Comparison of plasma α and γ tocopherol levels following chronic oral administration of either all-rac-α-tocopheryl acetate or RRR-α-tocopheryl acetate in normal adult male subjects

1986 • 107 citations

Serum α-Tocopherol Concentration in Relation to Subsequent Colorectal Cancer: Pooled Data From Five Cohorts

1992 • 106 citations

Effect of Vitamin A, C, and E Supplementation on Rectal Cell Proliferation in Patients With Colorectal Adenomas

1992 • 102 citations

Products of γ-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells

1995 • 101 citations

Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model

1994 • 99 citations

The effect of iron on experimental colorectal carcinogenesis.

1989 • 98 citations

Lipid peroxidation and prostaglandins in colorectal cancer

1994 • 92 citations

A comparison of the intestinal absorption, lymph and plasma transport, and tissue uptake of α- and γ-tocopherols in the rat

1972 • 90 citations

Neutrophil-mediated nitrosamine formation: Role of nitric oxide in rats

1992 • 88 citations

Biodiscrimination of the Eight α-Tocopherol Stereoisomers Results in Preferential Accumulation of the Four 2R Forms in Tissues and Plasma of Rats

1996 • 86 citations

RRR‐α‐tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways

1995 • 86 citations

Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4-hydroxy-2-nonenal

1996 • 84 citations

The effect of dietary ascorbic acid and α-tocopherol on fecal mutagenicity

1982 • 82 citations

Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes

1995 • 78 citations

Enhancing Effect of Vitamin E on Murine Intestinal Tumorigenesis by 1 ,2-Dimethylhydrazine Dihydrochloride<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 77 citations

A fish oil diet inhibits colon cancer in mice

1991 • 76 citations

Structural requirements for stimulation of colonic cell proliferation by oxidized fatty acids.

1988 • 67 citations

Free Radical Generating Mechanisms in the Colon: Their Role in the Induction and Promotion of Colorectal Cancer?

1989 • 65 citations

Alpha- and Gamma-Tocopherol in the Rat: in vitro and in vivo Tissue Uptake and Metabolism

1971 • 65 citations

Quantitative review of studies of dietary fat and rat colon carcinoma

1991 • 55 citations

Dietary Oxidized Frying Oil Enhances Tissue α-Tocopherol Depletion and Radioisotope Tracer Excretion in Vitamin E-Deficient Rats

1996 • 53 citations

Comparative uptake of α‐ and γ‐tocopherol by human endothelial cells

1992 • 50 citations

Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells

1995 • 49 citations

Metabolism of dietary genotoxins by the human colonic microflora; the fecapentaenes and heterocyclic amines

1990 • 48 citations

NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells

1993 • 48 citations

Occurrence of alpha-tocopherolquinone and alpha-tocopherolquinol in microorganisms

1982 • 48 citations

Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice

1993 • 46 citations

Roles of endogenous substances and bacteria in colorectal cancer

1993 • 44 citations

Study on the Specificity of -Tocopheryl (Vitamin E) Acid Succinate Effects on Melanoma, Glioma and Neuroblastoma Cells in Culture

1983 • 40 citations

n-3 pufa and α-tocopherol control of tumor cell proliferation

1993 • 36 citations

Evidence from cancer intervention and biomarker studies and the development of biochemical markers

1995 • 36 citations

Prostaglandin E2 Down-Regulates the Expression of HLA-DR Antigen in Human Colon Adenocarcinoma Cell Lines

1995 • 35 citations

Rectal cell proliferation and colorectal cancer risk level in patients with nonfamilial adenomatous polyps of the large bowel

1991 • 33 citations

Chemo- and dietary prevention of colorectal cancer

1995 • 33 citations

Increased cell membrane arachidonic acid in experimental colorectal tumours.

1991 • 33 citations

Effects of vitamin E deficiency on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats.

1985 • 20 citations

Use of alpha-tocopherylquinone in the treatment of ulcerative colitis.

1986 • 16 citations

Ulcerative colitis: The result of an altered bacterial metabolism of bile acids or cholesterol

1986 • 10 citations

The Internet Biologist

1995 • 9 citations

Is Chemoprevention Overrated or Underfunded?

1996 • 8 citations

Announcement

1990 • 5 citations

Stat Bite: Top 5 Causes of Cancer Death in U.S. Women and Men

1995 • 2 citations

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