The Human Kidney Is a Progesterone-Metabolizing and Androgen-Producing Organ

Transport of Steroid Hormones: Binding of 21 Endogenous Steroids to Both Testosterone-Binding Globulin and Corticosteroid-Binding Globulin in Human Plasma

1981 • 1,207 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.

1993 • 714 citations

Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1‒AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

2000 • 574 citations

Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

1998 • 537 citations

Neurosteroid metabolism in the human brain

2001 • 525 citations

Testosterone Exacerbates Hypertension and Reduces Pressure-Natriuresis in Male Spontaneously Hypertensive Rats

1998 • 318 citations

Purification and Characterization of the Corticosteroid 1lβ-Dehydrogenase Component of the Rat Liver 1lβ-Hydroxysteroid Dehydrogenase Complex*

1988 • 308 citations

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

1993 • 299 citations

INHIBITION OF THE SODIUM-RETAINING INFLUENCE OF ALDOSTERONE BY PROGESTERONE*†

1958 • 269 citations

Characteristics of a Highly Labile Human Type 5 17β-Hydroxysteroid Dehydrogenase1

1999 • 255 citations

The regulation of 17,20 lyase activity

1997 • 236 citations

The Role of Cytochrome b5 in the Biosynthesis of Androgens by Human P450c17

1995 • 224 citations

Transcortin: A Corticosteroid-Binding Protein of Plasma. X. Cortisol and Progesterone Interplay and Unbound Levels of These Steroids in Pregnancy

1969 • 211 citations

Gender Differences in Hypertension in Spontaneously Hypertensive Rats

1999 • 195 citations

Expression and Characterization of Recombinant Type 2 3α-Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3α/17β-HSD Activity and Cellular Distribution

1997 • 194 citations

THE METABOLIC EFFECTS OF PROGESTERONE IN MAN*†

1955 • 188 citations

Molecular Modeling of Human P450c17 (17α-Hydroxylase/ 17,20-Lyase): Insights into Reaction Mechanisms and Effects of Mutations

1999 • 183 citations

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.

1993 • 167 citations

Physiological modulation of GABAA receptor plasticity by progesterone metabolites

1999 • 154 citations

Close kinship of human 20α‐hydroxysteroid dehydrogenase gene with three aldo‐keto reductase genes

2000 • 145 citations

cDNA cloning, expression and characterization of human prostaglandin F synthase¹

1999 • 127 citations

Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor

2002 • 121 citations

ROLE OF ANDROGENS IN MEDIATING HYPERTENSION AND RENAL INJURY

1999 • 110 citations

Characterization of a human 20alpha-hydroxysteroid dehydrogenase

2000 • 105 citations

Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.

1993 • 102 citations

Type 5 17β-hydroxysteroid dehydrogenase: its role in the formation of androgens in women

2001 • 101 citations

Regional distribution of cytosolic and particulate 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductases in female rat brain

1997 • 96 citations

Antimineralocorticoid Action of Progesterone in the Rat: Correlation of the Effect on Electrolyte Excretion and Interaction with Renal Mineralocorticoid Receptors*

1978 • 91 citations

Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

2001 • 91 citations

Effect of Progesterone on Renal Sodium Handling in Man: Relation to Aldosterone Excretion and Plasma Renin Activity

1975 • 86 citations

Human Types 1 and 3 3α-Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution1

2001 • 73 citations

Expression and Characterization of Recombinant Type 2 3 -Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3 /17 -HSD Activity and Cellular Distribution

1997 • 66 citations

Recurrent Secretion of Progesterone in Large Amounts: An Endocrine/Metabolic Disorder Unique to Young Women?*

1991 • 62 citations

Progesterone Metabolism in the Human Kidney and Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 2 by Progesterone and Its Metabolites1

1999 • 55 citations

Effects of Progesterone and Estrogen on the Sensitivity to Angiotensin II

1967 • 51 citations

Progesterone Levels in Amniotic Fluid and Plasma from Women I. Levels during Normal Pregnancy

1971 • 50 citations

Clinical implications of glucocorticoid metabolism by 11beta-hydroxysteroid dehydrogenases in target tissues

2001 • 47 citations

The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.

1995 • 40 citations

Human Types 1 and 3 3 -Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution

2001 • 34 citations

Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney

2001 • 33 citations

Renal action of progesterone: effect on calcium reabsorption

2002 • 25 citations

The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent

1995 • 20 citations

Progesterone Metabolism in the Human Kidney and Inhibition of 11 -Hydroxysteroid Dehydrogenase Type 2 by Progesterone and Its Metabolites

1999 • 14 citations

Tissue progesterone concentrations of placentas in pre-eclamptic patients

1966 • 5 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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