Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

1994 • 1,043 citations

Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay

1985 • 860 citations

Statistical Concepts and Methods

1980 • 717 citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

1991 • 686 citations

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

1995 • 637 citations

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

1993 • 606 citations

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

1994 • 584 citations

Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)

1995 • 524 citations

Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase

1994 • 512 citations

Mortality in Patients with the Acquired Immunodeficiency Syndrome Treated with either Foscarnet or Ganciclovir for Cytomegalovirus Retinitis

1992 • 482 citations

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

1992 • 429 citations

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

1995 • 397 citations

A Controlled Trial Comparing Foscarnet with Vidarabine for Acyclovir-Resistant Mucocutaneous Herpes Simplex in the Acquired Immunodeficiency Syndrome

1991 • 364 citations

Antiviral effects of phosphonoformate (PFA, foscarnet sodium)

1982 • 339 citations

Site-specific mutagenesis of AIDS virus reverse transcriptase

1987 • 319 citations

Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes

1991 • 278 citations

Zidovudine Resistance and HIV-1 Disease Progression during Antiretroviral Therapy

1995 • 259 citations

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1992 • 236 citations

INHIBITION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE III IN VITRO BY PHOSPHONOFORMATE

1985 • 221 citations

Foscarnet Therapy in Five Patients with AIDS and Acyclovir-resistant Varicella-Zoster Virus Infection

1991 • 218 citations

Combination Therapy with Zidovudine and Didanosine Selects for Drug-Resistant Human Immunodeficiency Virus Type 1 Strains with Unique Patterns of pol Gene Mutations

1994 • 208 citations

Mechanism of action of foscarnet against viral polymerases

1992 • 189 citations

Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity.

1989 • 162 citations

Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance

1995 • 146 citations

Prevalence and Clinical Significance of Zidovudine Resistance Mutations in Human Immunodeficiency Virus Isolated from Patients after Long-Term Zidovudine Treatment

1995 • 141 citations

Combination Therapy with Zidovudine and Didanosine Compared with Zidovudine Alone in HIV-1 Infection

1993 • 136 citations

Review of HIV-1 reverse transcriptase three-dimensional structure: Implications for drug design

1993 • 131 citations

A Mutation in Human Immunodeficiency Virus Reverse Transcriptase and Decline in CD4 Lymphocyte Numbers in Long-Term Zidovudine Recipients

1993 • 129 citations

An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine

1996 • 110 citations

Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells

1990 • 109 citations

HIV-1 sensitivity to zidovudine and clinical outcome in children

1992 • 108 citations

Foscarnet Therapy for Severe Acyclovir-Resistant Herpes Simplex Virus Type-2 Infections in Patients with the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 107 citations

Drug Resistance and Heterogeneous Long-Term Virologic Responses of Human Immunodeficiency Virus Type 1-Infected Subjects to Zidovudine and Didanosine Combination Therapy

1995 • 105 citations

Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance

1994 • 98 citations

Phase I/II Evaluation of Nevirapine Alone and in Combination with Zidovudine for Infection with Human Immunodeficiency Virus

1995 • 93 citations

Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro

1989 • 88 citations

Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase: Nevirapine as a Prototype Drug

1992 • 87 citations

PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase

1986 • 84 citations

Effect of Foscarnet therapy on infection with human immunodeficiency virus in patients with AIDS.

1988 • 80 citations

Altered Sensitivity to Antiviral Drugs of Herpes Simplex Virus Isolates from a Patient with the Acquired Immunodeficiency Syndrome

1990 • 75 citations

Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

1995 • 70 citations

Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the Multicentre Canadian AZT Trial

1993 • 68 citations

Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

1989 • 66 citations

Characterisation of Foscarnet-Resistant Strains of Human Immunodeficiency Virus Type 1

1995 • 39 citations

Caseous lymphadenitis vaccine development: site-specific inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene

1995 • 31 citations

ISOLATION OF HIV FROM AUSTRALIAN PATIENTS WITH AIDS, AIDS RELATED CONDITIONS AND HEALTHY ANTIBODY POSITIVE INDIVIDUALS*

1987 • 28 citations

Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines

1994 • 25 citations

Foscarnet Decreases Human Immunodeficiency Virus RNA

1995 • 24 citations

Randomized study of didanosine monotherapy and combination therapy with zidovudine in hemophilic and nonhemophilic subjects with asymptomatic human immunodeficiency virus-1 infection. AIDS Clinical Trial Groups

1995 • 23 citations

Inhibition of human immunodeficiency virus reverse transcriptase by 2?,3?-dideoxynucleoside triphosphates: Template dependence, and combination with phosphonoformate

1989 • 20 citations

Reverse transcriptase mutations in sequential HIV‐1 isolates in a patient with AIDS

1995 • 20 citations

Investigation of Topoisomerase Inhibitors for Activity against Human Immunodeficiency Virus: Inhibition by Coumermycin A1

1990 • 15 citations

Long‐term foscarnet therapy not associated with the development of foscarnet‐resistant human immunodeficiency virus type 1 in an acquired immunodeficiency syndrome patient

1994 • 8 citations

Viral phenotype and genotype as markers in clinical trials.

1995 • 7 citations