Combination Therapy with Zidovudine and Didanosine Selects for Drug-Resistant Human Immunodeficiency Virus Type 1 Strains with Unique Patterns of pol Gene Mutations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

1992 • 429 citations

Ordered Appearance of Zidovudine Resistance Mutations during Treatment of 18 Human Immunodeficiency Virus-Positive Subjects

1992 • 369 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes

1991 • 278 citations

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1992 • 236 citations

Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.

1993 • 230 citations

HIV-1-Specific Reverse Transcriptase Inhibitors Show Differential Activity against HIV-1 Mutant Strains Containing Different Amino Acid Substitutions in the Reverse Transcriptase

1993 • 152 citations

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study.

1993 • 132 citations

Two-Drug Combinations of Zidovudine, Didanosine, and Recombinant Interferon- A Inhibit Replication of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Synergistically In Vitro

1991 • 131 citations

A Mutation in Human Immunodeficiency Virus Reverse Transcriptase and Decline in CD4 Lymphocyte Numbers in Long-Term Zidovudine Recipients

1993 • 129 citations

Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

1993 • 118 citations

Detection of Mutations Associated with Zidovudine Resistance in Human Immunodeficiency Virus by Use of the Polymerase Chain Reaction

1991 • 111 citations

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

1991 • 82 citations

Didanosine and zidovudine resistance patterns in clinical isolates of human immunodeficiency virus type 1 as determined by a replication endpoint concentration assay

1992 • 46 citations

Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Genomes Detected in Plasma Distinct from Viral Genomes in Peripheral Blood Mononuclear Cells

1993 • 40 citations

Zidovudine susceptibility testing of human immunodeficiency virus type 1 (HIV) clinical isolates

1993 • 14 citations

Zidovudine-resistant and -sensitive HIV-1 isolates from patients on drug therapy

1992 • 7 citations