Type 2 diabetes mellitus as a conformational disease.
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References (96)
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
2000 • 5,125 citations
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
1999 • 3,119 citations
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
2000 • 2,696 citations
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003 • 2,663 citations
Protein degradation and protection against misfolded or damaged proteins
2003 • 2,022 citations
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
2000 • 1,764 citations
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003 • 1,622 citations
A trip to the ER: coping with stress
2003 • 1,330 citations
Oxidative stress: From basic research to clinical application
1991 • 1,302 citations
NMR structure of the mouse prion protein domain PrP(121–231)
1996 • 1,251 citations
Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells
1997 • 1,144 citations
Chaperone-Mediated Protein Folding
1999 • 1,043 citations
The mechanism of Z α1-antitrypsin accumulation in the liver
1992 • 1,030 citations
Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes
2004 • 1,017 citations
Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications
1984 • 1,012 citations
Neurodegenerative diseases and oxidative stress
2003 • 986 citations
Transcriptional and Translational Control in the Mammalian Unfolded Protein Response
2002 • 909 citations
IRS proteins and the common path to diabetes
2002 • 907 citations
Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
2002 • 858 citations
Oxidative damage to DNA in diabetes mellitus
1996 • 789 citations
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.
1990 • 782 citations
Successful Islet Transplantation
2002 • 727 citations
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
2002 • 606 citations
The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.
1999 • 600 citations
Disulfide Bonds and Protein Folding
2000 • 575 citations
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.
2002 • 516 citations
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
1999 • 483 citations
Caspase‐12 and ER‐Stress‐Mediated Apoptosis
2003 • 475 citations
Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress
2004 • 445 citations
Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress
2001 • 416 citations
Kinetic partitioning of protein folding and aggregation
2002 • 414 citations
Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum
2000 • 408 citations
Glucose Sensing in Pancreatic β-Cells
2001 • 396 citations
INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES
1989 • 338 citations
Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology
2001 • 283 citations
Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis
1995 • 277 citations
Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
1987 • 274 citations
Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus
2004 • 268 citations
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family
2002 • 266 citations
Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat)
2004 • 260 citations
P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling
2003 • 246 citations
Review: Mechanisms of Disaggregation and Refolding of Stable Protein Aggregates by Molecular Chaperones
2001 • 237 citations
Structure of carbohydrate of hemoglobin AIc.
1977 • 225 citations
Increase in the glucosylated form of erythrocyte Cu-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity
1987 • 209 citations
Glucosylation of human collagen in aging and diabetes mellitus.
1980 • 208 citations
Effects of beta cell granule components on human islet amyloid polypeptide fibril formation
1996 • 194 citations
Islet amyloid polypeptide and type 2 diabetes
2003 • 193 citations
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase
2001 • 189 citations
Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: A short review
2004 • 177 citations
Serum proinsulin levels at fasting and after oral glucose load in patients with Type 2 (non-insulin-dependent) diabetes mellitus
1988 • 176 citations
Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
2002 • 171 citations
Oxidative Stress Response
2013 • 164 citations
Endoplasmic Reticulum Stress and Diabetes Mellitus.
2003 • 149 citations
Missense Mutation of Amylin Gene (S20G) in Japanese NIDDM Patients
1996 • 147 citations
Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.
1998 • 143 citations
Dislocation and degradation from the ER are regulated by cytosolic stress
2002 • 129 citations
An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport
2002 • 123 citations
Molecular chaperones, stress proteins and redox homeostasis
2003 • 120 citations
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide
2001 • 120 citations
Replication Increases β-Cell Vulnerability to Human Islet Amyloid Polypeptide-Induced Apoptosis
2003 • 116 citations
Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide
2004 • 111 citations
Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid
2003 • 110 citations
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation
2004 • 106 citations
Oxidative Stress Is a Mediator of Glucose Toxicity in Insulin-secreting Pancreatic Islet Cell Lines
2004 • 105 citations
Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
1998 • 102 citations
Vitamin C metabolites and microangiopathy in diabetes mellitus.
1987 • 101 citations
Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum
2002 • 89 citations
Rapid deposition of amyloid in human islets transplanted into nude mice
1995 • 89 citations
Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus.
2002 • 78 citations
Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history.
2000 • 72 citations
Molecular Basis for Defective Secretion of the Z Variant of Human Alpha-1-Proteinase Inhibitor: Secretion of Variants Having Altered Potential for Salt Bridge Formation between Amino Acids 290 and 342
1989 • 72 citations
A role for intermolecular disulfide bonds in prion diseases?
2001 • 69 citations
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese
2001 • 65 citations
Enhancedin vitroproduction of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide
2001 • 63 citations
Glutathione and Its Redox System in Diabetic Polymorphonuclear Leukocytes
1984 • 61 citations
The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: Evidence for associations with type 2 diabetes and cholesterol levels
2001 • 57 citations
Pancreatic pathology in non-insulin dependent diabetes (NIDDM)
1995 • 53 citations
"A" is for amylin and amyloid in type 2 diabetes mellitus.
2001 • 53 citations
Nitrosative Injury and Antioxidant Therapy in the Management of Diabetic Neuropathy
2004 • 45 citations
Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus.
2002 • 44 citations
Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP)
2000 • 43 citations
Pharmaceutical Strategies Against Amyloidosis: Old and New Drugs in Targeting a “Protein Misfolding Disease”
2004 • 42 citations
Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation
1998 • 39 citations
Macrophages and pancreatic islet amyloidosis
1998 • 39 citations
Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid
1992 • 38 citations
Nitric oxide and neuronal and pancreatic beta cell death
2000 • 36 citations
Relative Hypersecretion of Proinsulin in Rat Model of NIDDM
1991 • 35 citations
Non-enzymatic glycosylation of tissue protein in diabetes in the rat
1983 • 27 citations
Preferential release of proinsulin relative to insulin in non-insulin-dependent diabetes mellitus
1988 • 26 citations
Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori
2003 • 25 citations
beta-cell neogenesis in type 2 diabetes.
2001 • 24 citations
Anti-Aggregating Antibodies, a New Approach Towards Treatment of Conformational Diseases
2002 • 22 citations
Amyloid in Human Islets of Langerhans: Immunologic Evidence That Islet Amyloid Polypeptide Is Modified in Amyloidogenesis
2000 • 16 citations
Apoptosis and the β-Cell in Type 1 and Type 2 Diabetes
2004 • 9 citations
S20G mutation of the amylin gene in Japanese patients with type 2 diabetes
2000 • 7 citations
[The impact of the missense mutation-ser20gly in islet amyloid polypeptide gene on NIDDM in Chinese].
1998 • 2 citations