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Type 2 diabetes mellitus as a conformational disease.

Data up to Jan 2025

Published2005
Citations124
References96

Total Citations Per Year

Abstract

References (96)

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Protein degradation and protection against misfolded or damaged proteins

2003 • 2,022 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

2003 • 1,622 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

Oxidative stress: From basic research to clinical application

1991 • 1,302 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Chaperone-Mediated Protein Folding

1999 • 1,043 citations

The mechanism of Z α1-antitrypsin accumulation in the liver

1992 • 1,030 citations

Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes

2004 • 1,017 citations

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

Neurodegenerative diseases and oxidative stress

2003 • 986 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

IRS proteins and the common path to diabetes

2002 • 907 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Oxidative damage to DNA in diabetes mellitus

1996 • 789 citations

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

1990 • 782 citations

Successful Islet Transplantation

2002 • 727 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 606 citations

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1999 • 600 citations

Disulfide Bonds and Protein Folding

2000 • 575 citations

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.

2002 • 516 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

Caspase‐12 and ER‐Stress‐Mediated Apoptosis

2003 • 475 citations

Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress

2004 • 445 citations

Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress

2001 • 416 citations

Kinetic partitioning of protein folding and aggregation

2002 • 414 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

Glucose Sensing in Pancreatic β-Cells

2001 • 396 citations

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

1989 • 338 citations

Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology

2001 • 283 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

1987 • 274 citations

Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus

2004 • 268 citations

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

2002 • 266 citations

Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat)

2004 • 260 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Review: Mechanisms of Disaggregation and Refolding of Stable Protein Aggregates by Molecular Chaperones

2001 • 237 citations

Structure of carbohydrate of hemoglobin AIc.

1977 • 225 citations

Increase in the glucosylated form of erythrocyte Cu-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity

1987 • 209 citations

Glucosylation of human collagen in aging and diabetes mellitus.

1980 • 208 citations

Effects of beta cell granule components on human islet amyloid polypeptide fibril formation

1996 • 194 citations

Islet amyloid polypeptide and type 2 diabetes

2003 • 193 citations

Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase

2001 • 189 citations

Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: A short review

2004 • 177 citations

Serum proinsulin levels at fasting and after oral glucose load in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1988 • 176 citations

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

2002 • 171 citations

Oxidative Stress Response

2013 • 164 citations

Endoplasmic Reticulum Stress and Diabetes Mellitus.

2003 • 149 citations

Missense Mutation of Amylin Gene (S20G) in Japanese NIDDM Patients

1996 • 147 citations

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

1998 • 143 citations

Dislocation and degradation from the ER are regulated by cytosolic stress

2002 • 129 citations

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

2002 • 123 citations

Molecular chaperones, stress proteins and redox homeostasis

2003 • 120 citations

Amyloidogenicity and cytotoxicity of islet amyloid polypeptide

2001 • 120 citations

Replication Increases β-Cell Vulnerability to Human Islet Amyloid Polypeptide-Induced Apoptosis

2003 • 116 citations

Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide

2004 • 111 citations

Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

2003 • 110 citations

Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

2004 • 106 citations

Oxidative Stress Is a Mediator of Glucose Toxicity in Insulin-secreting Pancreatic Islet Cell Lines

2004 • 105 citations

Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

1998 • 102 citations

Vitamin C metabolites and microangiopathy in diabetes mellitus.

1987 • 101 citations

Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum

2002 • 89 citations

Rapid deposition of amyloid in human islets transplanted into nude mice

1995 • 89 citations

Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus.

2002 • 78 citations

Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history.

2000 • 72 citations

Molecular Basis for Defective Secretion of the Z Variant of Human Alpha-1-Proteinase Inhibitor: Secretion of Variants Having Altered Potential for Salt Bridge Formation between Amino Acids 290 and 342

1989 • 72 citations

A role for intermolecular disulfide bonds in prion diseases?

2001 • 69 citations

S20G mutation of the amylin gene is associated with Type II diabetes in Japanese

2001 • 65 citations

Enhancedin vitroproduction of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide

2001 • 63 citations

Glutathione and Its Redox System in Diabetic Polymorphonuclear Leukocytes

1984 • 61 citations

The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: Evidence for associations with type 2 diabetes and cholesterol levels

2001 • 57 citations

Pancreatic pathology in non-insulin dependent diabetes (NIDDM)

1995 • 53 citations

"A" is for amylin and amyloid in type 2 diabetes mellitus.

2001 • 53 citations

Nitrosative Injury and Antioxidant Therapy in the Management of Diabetic Neuropathy

2004 • 45 citations

Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus.

2002 • 44 citations

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP)

2000 • 43 citations

Pharmaceutical Strategies Against Amyloidosis: Old and New Drugs in Targeting a “Protein Misfolding Disease”

2004 • 42 citations

Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation

1998 • 39 citations

Macrophages and pancreatic islet amyloidosis

1998 • 39 citations

Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid

1992 • 38 citations

Nitric oxide and neuronal and pancreatic beta cell death

2000 • 36 citations

Relative Hypersecretion of Proinsulin in Rat Model of NIDDM

1991 • 35 citations

Non-enzymatic glycosylation of tissue protein in diabetes in the rat

1983 • 27 citations

Preferential release of proinsulin relative to insulin in non-insulin-dependent diabetes mellitus

1988 • 26 citations

Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori

2003 • 25 citations

beta-cell neogenesis in type 2 diabetes.

2001 • 24 citations

Anti-Aggregating Antibodies, a New Approach Towards Treatment of Conformational Diseases

2002 • 22 citations

Amyloid in Human Islets of Langerhans: Immunologic Evidence That Islet Amyloid Polypeptide Is Modified in Amyloidogenesis

2000 • 16 citations

Apoptosis and the β-Cell in Type 1 and Type 2 Diabetes

2004 • 9 citations

S20G mutation of the amylin gene in Japanese patients with type 2 diabetes

2000 • 7 citations

[The impact of the missense mutation-ser20gly in islet amyloid polypeptide gene on NIDDM in Chinese].

1998 • 2 citations

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