Islet amyloid polypeptide and type 2 diabetes

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

1987 • 957 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

1990 • 782 citations

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1988 • 506 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

United Kingdom Prospective Diabetes Study 17: A 9-Year Update of a Randomized, Controlled Trial on the Effect of Improved Metabolic Control on Complications in Non-Insulin-dependent Diabetes Mellitus

1996 • 468 citations

Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin

1996 • 439 citations

Evidence of Cosecretion of Islet Amyloid Polypeptide and Insulin by β-Cells

1990 • 435 citations

Protofibrillar Islet Amyloid Polypeptide Permeabilizes Synthetic Vesicles by a Pore-like Mechanism that May Be Relevant to Type II Diabetes

2002 • 290 citations

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1996 • 282 citations

In vitro autoradiographic localization of amylin binding sites in rat brain

1994 • 264 citations

Identification of a novel human islet amyloid polypeptide β-sheet domain and factors influencing fibrillogenesis

2001 • 233 citations

Hyperproinsulinemia and Amyloid in NIDDM: Clues to Etiology of Islet β-Cell Dysfunction?

1989 • 186 citations

Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population

1993 • 163 citations

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin)

1998 • 156 citations

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

1999 • 153 citations

Missense Mutation of Amylin Gene (S20G) in Japanese NIDDM Patients

1996 • 147 citations

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

1998 • 143 citations

Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin

1999 • 138 citations

The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH2-Terminal Cleavage Site

2001 • 109 citations

Identification of a Heparin Binding Domain in the N-terminal Cleavage Site of Pro-islet Amyloid Polypeptide

2001 • 101 citations

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

1994 • 100 citations

Amyloid and polypeptide hormones: What is their interrelationship?

1994 • 93 citations

Rapid deposition of amyloid in human islets transplanted into nude mice

1995 • 89 citations

Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans

1989 • 79 citations

Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.

1999 • 74 citations

Multiple Ramp Domains Are Required for Generation of Amylin Receptor Phenotype from the Calcitonin Receptor Gene Product

2000 • 72 citations

Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.

1998 • 70 citations

Intracellular Amyloidogenesis by Human Islet Amyloid Polypeptide Induces Apoptosis in COS-1 Cells

1999 • 69 citations

Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

2000 • 63 citations

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

1999 • 57 citations

Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 Type 2 (non-insulin-dependent) diabetic patients

1990 • 51 citations

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