Role of Serine 10 Phosphorylation in p27 Stabilization Revealed by Analysis of p27 Knock-in Mice Harboring a Serine 10 Mutation

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

Principles of CDK regulation

1995 • 3,267 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

1997 • 1,055 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1997 • 929 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

1997 • 861 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1999 • 702 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1999 • 593 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

2001 • 467 citations

pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1995 • 460 citations

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

1996 • 432 citations

High level expression of p27 ^kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 ^kip1 and degree of malignancy in human breast and colorectal cancers

1997 • 364 citations

A CDK-Independent Function of Mammalian Cks1

2001 • 356 citations

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.

1997 • 354 citations

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.

1995 • 338 citations

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

1995 • 327 citations

The Prognostic Significance of Altered Cyclin-Dependent Kinase Inhibitors in Human Cancer

1999 • 323 citations

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

2001 • 291 citations

A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression

2002 • 281 citations

Phosphorylation of p27 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export

2002 • 267 citations

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

2001 • 254 citations

Down-regulation of p27 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

1999 • 231 citations

Degradation of p27 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

2001 • 210 citations

Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 , Increases Its Protein Stability

2000 • 209 citations

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

1995 • 207 citations

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

1999 • 197 citations

Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development

1999 • 195 citations

CRM1/Ran-Mediated Nuclear Export of p27^Kip1Involves a Nuclear Export Signal and Links p27 Export and Proteolysis

2003 • 178 citations

p27/Kip1 mutation found in breast cancer.

1996 • 174 citations

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma

1995 • 134 citations

Role of p27Kip1 and Cyclin-Dependent Kinase 2 in the Proliferation of Non-Small Cell Lung Cancer

1998 • 97 citations

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27 Kip1 and p57 Kip2 during mouse development

2001 • 97 citations

Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas

1996 • 86 citations

Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.

1996 • 67 citations

Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas

1996 • 50 citations

Germline configuration of the p27(Kip1) gene in childhood acute lymphoblastic leukemia (ALL).

1996 • 8 citations