Regulation of myosin and overall protein degradation in mouse C2 skeletal myotubes

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

1977 • 2,070 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Cytoplasmic activation of human nuclear genes in stable heterocaryons

1983 • 839 citations

Plasticity of the Differentiated State

1985 • 839 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

The use of Coomassie Brilliant Blue G250 perchloric acid solution for staining in electrophoresis and isoelectric focusing on polyacrylamide gels

1975 • 622 citations

Protein Turnover in Skeletal Muscle

1969 • 317 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA

1982 • 295 citations

Electrophoretic analysis of multiple forms of myosin in fast-twitch and slow-twitch muscles of the chick

1976 • 279 citations

Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors

1989 • 263 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Insulin-like Growth Factors (IGF) in Muscle Development

1989 • 228 citations

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle

1986 • 221 citations

Mechanism and regulation of protein degradation in liver

1989 • 220 citations

Pathogenesis of Muscular Dystrophies

1976 • 215 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain.

1979 • 186 citations

Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins

1986 • 179 citations

Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation.

1989 • 174 citations

Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle

1988 • 147 citations

Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis

1987 • 140 citations

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro

1987 • 127 citations

Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts

1986 • 120 citations

Insulin‐like growth factor binding protein secretion by muscle cells: Effect of cellular differentiation and proliferation

1988 • 119 citations

Parturition-related changes in insulin-like growth factors-I and -II in the perinatal lamb

1983 • 115 citations

Myofibrillar protein turnover. Synthesis rates of myofibrillar and sarcoplasmic protein fractions in different muscles and the changes observed during postnatal development and in response to feeding and starvation

1983 • 110 citations

Isolation and Characterization of Myosin from Cloned Mouse Fibroblasts

1972 • 105 citations

Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin

1980 • 103 citations

Regulation of protein synthesis and degradation in L8 myotubes. Effects of serum, insulin and insulin-like growth factors

1989 • 100 citations

The metabolism of myosin, the meromyosins, actin and tropomyosin in the rabbit

1956 • 98 citations

Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation

1986 • 97 citations

Specific inhibition by NH4Cl of autophagy-associated proteolysis in cultured fibroblasts

1978 • 94 citations

Rat Skeletal Muscle Cells

1973 • 90 citations

Isoform variants of troponin in skeletal and cardiac muscle cells cultured with and without nerves

1983 • 88 citations

Type IIB to IIA fiber transformation in intermittently stimulated rabbit muscles

1982 • 85 citations

Developmental Expression of Receptors for Insulin, Insulin-like Growth Factor I (IGF-I), and IGF-II in Rat Skeletal Muscle*

1989 • 80 citations

Inhibition of protein breakdown in cultured cells is a consistent response to growth factors

1980 • 75 citations

Protein degradation in embryonic skeletal muscle. Effect of medium, cell type, inhibitors, and passive stretch.

1980 • 62 citations

Pre‐ and postnatal growth and protein turnover in four muscles of the rat

1984 • 61 citations

Coordinated synthesis and degradation of actin and myosin in a variety of myogenic and non-myogenic cells

1976 • 56 citations

Effects of food deprivation and refeeding on total protein and actomyosin degradation

1984 • 52 citations

Myofibrillar protein turnover. Synthesis of protein-bound 3-methylhistidine, actin, myosin heavy chain and aldolase in rat skeletal muscle in the fed and starved states

1983 • 52 citations

Differential effects of acute changes in cell Ca2+ concentration on myofibrillar and non-myofibrillar protein breakdown in the rat extensor digitorum longus muscle in vitro. Assessment by production of tyrosine and Nτ-methylhistidine

1987 • 50 citations

Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length

1990 • 48 citations

Inhibition of intracellular proteolysis in muscle cultures by multiplication-stimulating activity. Comparison of effects of multiplication-stimulating activity and insulin on proteolysis, protein synthesis, amino acid uptake, and sugar transport.

1984 • 45 citations

Rat Skeletal Muscle Cells11This work was supported by Grant No. DRG 10007 from the Damon Ruyon Memorial Fund for Cancer Research, a grant-in-aid from the Muscular Dystrophy Association of America, Inc., and a long-term fellowship from EMBO. The valuable comments and suggestions of Sara Neuman, Erika Krull, H. Dym, G. Lavie, and S. Kaufman during the preparation of this manuscript are gratefully acknowledged.

1973 • 42 citations

NONUNIFORM RATES OF TURNOVER OF MYOFIBRILLAR PROTEINS IN RAT DIAPHRAGM

1973 • 40 citations

Diazepam Inhibits Myoblast Fusion and Expression of Muscle Specific Protein Synthesis

1978 • 38 citations

Interference with lysosomal proteolysis fails to reduce cardiac myosin degradation

1980 • 35 citations

Myosin turnover in cultured muscle fibers relaxed by tetrodotoxin

1978 • 31 citations

Changes in the properties of myosin associated with muscle development

1971 • 25 citations

Proteolysis in cultured cells during prolonged serum deprivation and replacement

1986 • 24 citations

Turnover of myosin heavy and light chains in cultured embryonic chick cardiac and skeletal muscle

1976 • 18 citations

Regulation of myofibrillar accumulation in chick muscle cultures: evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteins.

1985 • 13 citations

Biosynthetic Changes of Myosin Heavy Subunit during Myogenesis in Culture

1978 • 11 citations

Metabolism of myosin heavy chain in steady-state chick skeletal muscle cultures

1981 • 10 citations

Turnover of the creatine kinase subunits in chicken myogenic cell cultures and in fibroblasts

1981 • 8 citations

Protein turnover in heart and diaphragm of rat fetus

1984 • 7 citations

Deleted Work

1955 • 0 citations