New Immunosuppressive Drugs: Mechanistic Insights and Potential Therapeutic Advances

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance

1993 • 795 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

Tacrolimus

1993 • 355 citations

CHIMERISM AND DONOR-SPECIFIC NONREACTIVITY 27 TO 29 YEARS AFTER KIDNEY ALLOTRANSPLANTATION

1993 • 346 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides

1992 • 259 citations

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

1993 • 251 citations

RS-61443—A PHASE I CLINICAL TRIAL AND PILOT RESCUE STUDY 1

1992 • 245 citations

RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENT

1991 • 239 citations

SYNERGISTIC INTERACTIONS OF CYCLOSPORINE AND RAPAMYCIN TO INHIBIT IMMUNE PERFORMANCES OF NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO

1991 • 205 citations

RAPAMYCIN INHIBITS ARTERIAL INTIMAL THICKENING CAUSED BY BOTH ALLOIMMUNE AND MECHANICAL INJURY

1993 • 204 citations

Leukocyte chemotactic activity of cyclophilin.

1992 • 203 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

FK-506 — How much potential?

1989 • 181 citations

CADAVERIC SMALL BOWEL AND SMALL BOWEL-LIVER TRANSPLANTATION IN HUMANS 1,2

1992 • 173 citations

Rapamycin: A novel immunosuppressive macrolide

1994 • 166 citations

Long survival in rats after multivisceral versus isolated small-bowel allotransplantation under FK 506.

1991 • 164 citations

Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15-deoxyspergualin

1993 • 162 citations

HAMSTER-TO-RAT HEART AND LIVER XENOTRANSPLANTATION WITH FK506 PLUS ANTIPROLIFERATIVE DRUGS

1993 • 155 citations

PRECLINICAL EVALUATION OF A NEW POTENT IMMUNOSUPPRESSIVE AGENT, RAPAMYCIN

1991 • 147 citations

Calcineurin Is a Key Signaling Enzyme in T Lymphocyte Activation and the Target of the Immunosuppressive Drugs Cyclosporin A and FK506^a

1993 • 131 citations

Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas

1992 • 101 citations

A NOVEL RESCUE DRUG, 15-DEOXYSPERGUALIN

1990 • 99 citations

Leprosy and the Leprosy Bacillus: Recent Developments in Characterization of Antigens and Immunology of the Disease

1987 • 96 citations

Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts.

1991 • 94 citations

LEFLUNOMIDE, A NOVEL IMMUNOSUPPRESSIVE AGENT

1993 • 92 citations

EVIDENCE THAT LONG-TERM SURVIVAL OF CONCORDANT XENOGRAFTS IS ACHIEVED BY INHIBITION OF ANTISPECIES ANTIBODY PRODUCTION

1992 • 90 citations

PRODUCTION OF SYNERGISTIC BUT NONIDENTICAL MECHANISMS OF IMMUNOSUPPRESSION BY RAPAMYCIN AND CYCLOSPORINE

1991 • 88 citations

Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts.

1991 • 82 citations

INDUCTION OF LONG-TERM SURVIVAL OF HAMSTER HEART XENOGRAFTS IN RATS

1991 • 81 citations

Pharmacology of cyclosporine (sandimmune). V. Pharmacological effects on immune function: in vitro studies.

1990 • 73 citations

INHIBITION OF IN VITRO IMMUNOGLOBULIN PRODUCTION BY RAPAMYCIN1

1992 • 72 citations

T cell-specific negative regulation of transcription of the human cytokine IL-4.

1992 • 67 citations

The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat.

1989 • 67 citations

Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions.

1991 • 65 citations

Altered protein tyrosine phosphorylation in anergic Th1 cells.

1993 • 65 citations

FK 506: a novel immunosuppressant for treatment of autoimmune disease

1993 • 60 citations

A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.

1993 • 47 citations

Immunosuppressive drugs: Developments in anti-rejection therapy

1994 • 46 citations

Rapamycin Inhibits p34^cdc2 Expression and Arrests T Lymphocyte Proliferation at the G1/S Transition

1993 • 46 citations

SUPPRESSION OF SYNTHESIS OF NATURAL ANTIBODIES BY MYCOPHENOLATE MOFETIL (RS-61443)

1993 • 46 citations

Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity.

1993 • 42 citations

Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506.

1990 • 40 citations

FACILITATION OF SPECIFIC TOLERANCE INDUCTION IN ADULT MICE BY RS-61443

1992 • 39 citations

FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line.

1991 • 34 citations

Markedly enhanced therapeutic effect of deoxyspergualin on acute rejection when combined with methylprednisolone in kidney recipients.

1991 • 26 citations

Fk 506 and Autoimmune Disease: Perspective and Prospects

1992 • 25 citations

The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo.

1991 • 24 citations

Historical development of brequinar sodium as a new immunosuppressive drug for transplantation.

1993 • 22 citations

The molecular biology of immunosuppression

1992 • 19 citations

INDUCTION OF NONSPECIFIC X-IRRADIATION-RESISTANT SUPPRESSOR CELL ACTIVITY IN VIVO AND PROLONGATION OF VASCULARIZED ALLOGRAFT SURVIVAL BY SK&F 105685, A NOVEL IMMUNOMODULATORY AZASPIRANE

1993 • 14 citations

THE ANTILYMPHOCYTIC ACTIVITY OF BREQUINAR SODIUM AND ITS POTENTIATION BY CYTIDINE

1993 • 14 citations

Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells.

1993 • 11 citations

RS‐61443: Mechanism of action, experimental and early clinical results

1991 • 11 citations

Comparison of the immunosuppressive and toxic effects of FK506 and cyclosporine in xenograft recipients.

1989 • 10 citations

THE EFFECTS OF RAPAMYCIN ON HUMORAL IMMUNITY IN VIVO SUPPRESSION OF PRIMARY RESPONSES BUT NOT OF ONGOING ALLOANTIBODY SYNTHESIS OR MEMORY RESPONSES

1992 • 9 citations

Cytidine Potentiates the Inhibitory Effect of Brequinar Sodium on Xeno‐MLR, Antibody Production, and Concordant Hamster to Rat Cardiac Xenograft Survival^a

1993 • 9 citations

± 15‐deoxyspergualin: A mystery wrapped within an enigma

1991 • 7 citations

FK 506: Pharmacology and molecular action

1993 • 2 citations

Potentiation of the antiproliferative activity of brequinar sodium for murine lymphocytes by exogenous cytidine.

1993 • 1 citations

Deleted Work

1955 • 0 citations