Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours

The Basic Science of Gene Therapy

1993 • 1,767 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

Human gene therapy comes of age

1992 • 927 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Human gene therapy

1992 • 559 citations

Correct integration of retroviral DNA in vitro

1987 • 459 citations

Improved Methods of Retroviral Vector Transduction and Production for Gene Therapy

1994 • 382 citations

A nucleoprotein complex mediates the integration of retroviral DNA.

1989 • 381 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus

1992 • 337 citations

Gene Transfer by Retrovirus Vectors Occurs Only in Cells That Are Actively Replicating at the Time of Infection

1990 • 273 citations

Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA

1977 • 220 citations

Human Gene Therapy

1992 • 206 citations

Integration of Retroviral DNA

1990 • 161 citations

Deficiency of 60 to 70 S RNA in Murine Leukemia Virus Particles Assembled in Cells Treated with Actinomycin D

1974 • 151 citations

Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent

1989 • 129 citations

Retroviral Infection Is Limited by Brownian Motion

1996 • 124 citations

Synthesis of murine leukemia virus proteins associated with virions assembled in actinomycin D-treated cells: evidence for persistence of viral messenger RNA.

1976 • 113 citations

Integration of mini-retroviral DNA: a cell-free reaction for biochemical analysis of retroviral integration.

1989 • 111 citations

Consistent and High Rates of Gene Transfer Can Be Obtained Using Flow-Through Transduction over a Wide Range of Retroviral Titers

1996 • 110 citations

Evidence that retroviruses integrate into post-replication host DNA.

1993 • 110 citations

Cell cycle dependence of synthesis of unintegrated viral DNA in mouse cells newly infected with murine leukemia virus

1981 • 101 citations

Increased Viral Titer Through Concentration of Viral Harvests from Retroviral Packaging Lines

1993 • 86 citations

Inhibition of viral DNA synthesis in stationary chicken embryo fibroblasts infected with avian retroviruses

1977 • 84 citations

The Vector Void in Gene Therapy

1995 • 78 citations

Mechanisms of Retrovirus Replication

1992 • 75 citations

Cell cycle perturbations in normal and transformed fibroblasts caused by detachment from the substratum

1983 • 36 citations

Synthesis of the RNA of RNA-containing tumor viruses

1970 • 33 citations

Cell cycle dependence of retroviral transduction: An issue of overlapping time scales

1998 • 30 citations

Kinetics of Retrovirus Mediated Gene Transfer: The Importance of Intracellular Half-Life of Retroviruses

1996 • 27 citations

Gene Transfer into Human Hematopoietic Progenitor Cells: A Review of Current Clinical Protocols

1993 • 22 citations

Dynamics of retrovirus-mediated gene transfer.

1996 • 1 citations