Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Epidermal Lipids, Barrier Function, and Desquamation

1983 • 1,296 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

1984 • 393 citations

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1985 • 384 citations

Studies on Contact Sensitivity to Chromium in the Guinea Pig. The Role of Valence in the Formation of the Antigenic Determinant

1983 • 354 citations

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

1988 • 336 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Lamellar Body Secretory Response to Barrier Disruption

1992 • 285 citations

Barrier function regulates epidermal DNA synthesis.

1991 • 252 citations

Relationship of epidermal lipogenesis to cutaneous barrier function.

1987 • 245 citations

Regulation of epidermal sphingolipid synthesis by permeability barrier function.

1991 • 227 citations

Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation.

1991 • 220 citations

Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury.

1991 • 216 citations

The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition.

1978 • 215 citations

Lipoprotein Uptake by Neuronal Growth Cones in Vitro

1987 • 209 citations

De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements.

1985 • 208 citations

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

1983 • 200 citations

Cholesterol synthesis is required for cutaneous barrier function in mice.

1990 • 191 citations

Reorganisation of peripheral actin filaments as a prelude to exocytosis

1987 • 144 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

1978 • 143 citations

Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy.

1989 • 131 citations

Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells.

1990 • 124 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements.

1990 • 115 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control.

1985 • 83 citations

Characterization of the estrogen-induced lipoprotein receptor of rat liver.

1986 • 78 citations

Transcriptional and posttranscriptional regulation of rat hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by thyroid hormones.

1988 • 74 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.

1983 • 73 citations

Effect of Essential Fatty Acid Deficiency on Cutaneous Sterol Synthesis

1986 • 69 citations

Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.

1989 • 66 citations

Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver.

1985 • 58 citations

Low Density Lipoprotein Receptor Expression on Keratinocytes in Normal and Psoriatic Epidermis

1987 • 55 citations

Synthesis and Secretion of Apolipoprotein E by Cultured Human Keratinocytes

1989 • 45 citations

The regulation of epidermal lipid synthesis by permeability barrier requirements.

1991 • 34 citations

Synthesis and secretion of apolipoprotein A-I by chick skin.

1991 • 22 citations