Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

RNA interference targeting Fas protects mice from fulminant hepatitis

2003 • 1,106 citations

RNA interference in adult mice

2002 • 1,060 citations

siRNA-mediated gene silencing in vitro and in vivo

2002 • 880 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Inhibition of hepatitis B virus in mice by RNA interference

2003 • 616 citations

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

2002 • 561 citations

Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents

2003 • 447 citations

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo

2002 • 402 citations

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

1997 • 366 citations

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C- raf kinase supports an antisense mechanism of action in vivo

1996 • 136 citations

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

1996 • 122 citations

Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice.

1997 • 105 citations

Altered mRNA Splicing and Inhibition of Human E-selectin Expression by an Antisense Oligonucleotide in Human Umbilical Vein Endothelial Cells

1996 • 58 citations

Genasense (Genta Inc).

2001 • 54 citations

Inhibition of cancer cell growth by polyinosinic-polycytidylic acid/cationic liposome complex: a new biological activity.

1999 • 49 citations

Cellular Distribution of Phosphorothioate Oligonucleotide Following Intravenous Administration in Mice

1998 • 41 citations

In vitro inhibition of hepatitis C virus gene expression by chemically modified antisense oligodeoxynucleotides

1996 • 36 citations

Inhibition of metastatic carcinoma cell growth in livers by poly(I):poly(C)/cationic liposome complex (LIC).

1999 • 9 citations

Antisense therapy for B cell lymphomas.

1997 • 4 citations