Targeting gene expression to specific cardiovascular cell types in transgenic mice.

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

1990 • 913 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

RETRACTED: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.

1991 • 769 citations

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

1982 • 698 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

1990 • 617 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

1992 • 491 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting

1987 • 478 citations

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

1987 • 445 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs.

1988 • 443 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform.

1989 • 388 citations

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

1988 • 374 citations

Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle.

1987 • 374 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 371 citations

Transgenic Mice as Probes into Complex Systems

1989 • 368 citations

ATRIAL NATRIURETIC FACTOR AND RELATED PEPTIDE HORMONES

1991 • 368 citations

Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

1990 • 339 citations

Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis

1989 • 300 citations

Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation.

1988 • 297 citations

MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer

1992 • 290 citations

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

1989 • 283 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias in Mice

1988 • 275 citations

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.

1991 • 273 citations

Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart.

1991 • 244 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

1993 • 242 citations

Cardiac myocytes express multiple gap junction proteins.

1992 • 234 citations

Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning.

1988 • 233 citations

Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms.

1986 • 225 citations

Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours.

1992 • 219 citations

cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms.

1990 • 219 citations

Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development

1992 • 216 citations

Troponin I Switching in the Developing Heart

1989 • 212 citations

Molecular Cloning of the Mammalian Smooth Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase

1989 • 204 citations

Muscle Creatine Kinase Sequence Elements Regulating Skeletal and Cardiac Muscle Expression in Transgenic Mice

1989 • 204 citations

Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.

1987 • 201 citations

Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.

1991 • 201 citations

Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart.

1991 • 197 citations

Antisera specific for the .alpha.1, .alpha.2, .alpha.3, and .beta. subunits of the sodium-potassium ATPase: differential expression of .alpha. and .beta. subunits in rat tissue membranes

1989 • 195 citations

Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1

1991 • 192 citations

Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing

1989 • 187 citations

Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic Mice

1988 • 182 citations

The c-myc proto-oncogene regulates cardiac development in transgenic mice.

1990 • 181 citations

Diet-Induced Hypercholesterolemia in Mice: Prevention by Overexpression of LDL Receptors

1990 • 179 citations

The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression.

1992 • 178 citations

Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.

1990 • 170 citations

Cytoskeletal features of normal andatheromatous human arterial smooth muscle cells

1986 • 163 citations

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.

1989 • 162 citations

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene

1991 • 161 citations

Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage.

1989 • 158 citations

Myocardial recruitment during ANF mRNA increase with volume overload in the rat

1986 • 147 citations

Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.

1990 • 147 citations

Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes.

1990 • 145 citations

Influence of thyroid hormone and retinoic acid on slow sarcoplasmic reticulum Ca2+ ATPase and myosin heavy chain alpha gene expression in cardiac myocytes. Delineation of cis-active DNA elements that confer responsiveness to thyroid hormone but not to retinoic acid

1991 • 145 citations

A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells.

1991 • 144 citations

Identification of atrial natriuretic factor within ventricular tissue in hamsters and humans with congestive heart failure.

1988 • 143 citations

Structure, organization, and expression of the rat cardiac myosin light chain-2 gene

1989 • 140 citations

Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.

1992 • 137 citations

Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis

1991 • 128 citations

The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load.

1991 • 119 citations

A Single Troponin T Gene Regulated by Different Programs in Cardiac and Skeletal Muscle Development

1984 • 113 citations

Heart conduction system: a neural crest derivative?

1988 • 110 citations

Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.

1992 • 108 citations

Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice.

1989 • 107 citations

Tissue-specific expression of the voltage-sensitive sodium channel

1992 • 104 citations

Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis.

1988 • 100 citations

Correlation between the distribution of smooth muscle or non muscle myosins and ?-smooth muscle actin in normal and pathological soft tissues

1988 • 99 citations

Heart and bone tumors in transgenic mice.

1988 • 98 citations

Cardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes

1992 • 95 citations

Distribution of isoelectric variants of the 17,000-dalton myosin light chain in mammalian smooth muscle.

1988 • 94 citations

Troponin T switching in the developing rat heart.

1988 • 92 citations

A Novel, Tissue-Restricted Zinc Finger Protein (HF-1b) Binds to the Cardiac Regulatory Element (HF-1b/MEF-2) in the Rat Myosin Light-Chain 2 Gene

1993 • 85 citations

Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart

1992 • 81 citations

Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells

1989 • 81 citations

Genetic ablation in transgenic mice.

1989 • 74 citations

Molecular Advances in Cardiovascular Biology

1993 • 71 citations

Distribution of conduction system fibers in the developing and adult rabbit heart revealed by an antineurofilament antibody.

1989 • 66 citations

The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase.

1992 • 64 citations

Developmental expression of rat cardiac troponin I mRNA

1991 • 63 citations

Mouse phospholamban gene expression during development in vivo and in vitro.

1992 • 63 citations

Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat.

1986 • 61 citations

Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development

1990 • 56 citations

The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice.

1989 • 54 citations

Expression of diverse Na+ channel messenger RNAs in rat myocardium. Evidence for a cardiac-specific Na+ channel.

1989 • 53 citations

Neurofilament proteins are co-expressed with desmin in heart conduction system myocytes

1990 • 46 citations

Myosin types and fiber types in cardiac muscle. III. Nodal conduction tissue.

1986 • 46 citations

Tissue plasminogen activator mRNA in murine tissues

1988 • 44 citations

The human von Willebrand factor gene

1988 • 41 citations

Developmental expression of cloned cardiac potassium channels

1991 • 40 citations

Oncogenes in transgenic mice

1988 • 38 citations

Distribution of tissue-type plasminogen activator (activity and antigen) in rat tissues.

1990 • 37 citations

Expression and organization of muscle specific proteins during the early developmental stages of the rabbit heart

1992 • 36 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 35 citations

Neural cell adhesion molecule (N-CAM) expression during cardiac development in the rat

1989 • 34 citations

Antisense RNA production in transgenic mice

1990 • 33 citations

Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I

1991 • 31 citations

Atrial natriuretic factor

1991 • 31 citations

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

1989 • 24 citations

An embryonic-like myosin heavy chain is transiently expressed in nodal conduction tissue of the rat heart

1988 • 24 citations

Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon‐inducible gene

1988 • 23 citations

Expression and Function of Cell Adhesion Molecules during the Early Development of the Heart^a

1990 • 23 citations

Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.

1990 • 23 citations

Functional identification of the transcriptional regulatory elements within the promoter region of the human ventricular myosin alkali light chain gene.

1990 • 22 citations

The c-myc proto-oncogene regulates cardiac development in transgenic mice

1990 • 22 citations

The Chicken Skeletal Muscle α-Actin Promoter Is Tissue Specific in Transgenic Mice

1989 • 21 citations

Atrial Natriuretic Factor And Related Peptide Hormones

1991 • 20 citations

Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.

1990 • 15 citations

Troponin T switching in the developing rat heart

1987 • 7 citations

Analysis of the elam-1 and vcam-1 promoters- tools to target gene expression in endothelium in transgenic animals

1992 • 5 citations

Deleted Work

1955 • 0 citations