The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Myosin isoenzyme redistribution in chronic heart overload

1979 • 524 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

Stretching cardiac myocytes stimulates protooncogene expression.

1990 • 470 citations

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

1987 • 445 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes.

1990 • 377 citations

Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.

1989 • 308 citations

Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation.

1988 • 297 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

The Effects of Antihypertensive Therapy on Left Ventricular Mass in Elderly Patients

1990 • 249 citations

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.

1990 • 237 citations

Growth Factors Proto-Oncogenes and Plasticity of the Cardiac Phenotype

1991 • 228 citations

Expression of cellular oncogenes in the myocardium during the developmental stage and pressure-overloaded hypertrophy of the rat heart.

1988 • 222 citations

Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1

1990 • 221 citations

Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.

1987 • 201 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation

1989 • 187 citations

α-Smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles

1988 • 183 citations

Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

1989 • 154 citations

Cellular distribution of smooth muscle actins during mammalian embryogenesis: expression of the alpha-vascular but not the gamma-enteric isoform in differentiating striated myocytes.

1989 • 149 citations

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.

1990 • 146 citations

Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes

1989 • 135 citations

Reexpression of α-smooth muscle actin isoform in cultured adult rat cardiomyocytes

1990 • 131 citations

Cardiac myocytes as targets for the action of peptide growth factors.

1990 • 126 citations

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

1990 • 124 citations

Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.

1991 • 124 citations

Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy.

1991 • 110 citations

Modulation of actin isoform expression in alveolar myofibroblasts (contractile interstitial cells) during pulmonary hypertension.

1990 • 107 citations

Differential regulation of skeletal alpha-actin transcription in cardiac muscle by two fibroblast growth factors.

1990 • 103 citations

A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle.

1988 • 102 citations

A hemodynamic load in vivo induces cardiac expression of the cellular oncogene, c-myc

1987 • 94 citations

Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter.

1989 • 93 citations

Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.

1990 • 91 citations

A 29-Nucleotide DNA Segment Containing an Evolutionarily Conserved Motif is Required in cis for Cell-Type-Restricted Repression of the Chicken α-Smooth Muscle Actin Gene Core Promoter

1988 • 76 citations

Differentiation of cardiac myocytes after mitogen withdrawal exhibits three sequential states of the ventricular growth response.

1988 • 72 citations

Molecular signals for initiating protein synthesis in organ hypertrophy.

1979 • 72 citations

Alteration in crossbridge kinetics caused by mutations in actin

1990 • 67 citations

Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes.

1989 • 64 citations

Effect of thyroid hormone on the accumulation of mRNA for skeletal and cardiac alpha-actin in hearts from normal and hypophysectomized rats.

1990 • 60 citations

mXBP/CRE-BP2 and c-Jun Form a Complex Which Binds to the Cyclic AMP, but Not to the 12-O-Tetradecanoylphorbol-13-Acetate, Response Element

1990 • 56 citations

Coronary flow as a determinant of c-myc and c-fos proto-oncogene expression in an isolated adult rat heart

1988 • 50 citations

Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region.

1990 • 45 citations

Changes of atrial natriuretic peptide and its messenger RNA with development and regression of cardiac hypertrophy in renovascular hypertensive rats.

1990 • 45 citations

A developmental study of the abnormal expression of α-cardiac and α-skeletal actins in the striated muscle of a mutant mouse

1989 • 35 citations

Modulation of cardiac genes by mechanical stress. The oncogene signalling hypothesis.

1991 • 34 citations

Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac α-Actin Promoter

1989 • 34 citations

A Common Factor Regulates Skeletal and Cardiac α-Actin Gene Transcription in Muscle

1988 • 31 citations

A 29-nucleotide DNA segment containing an evolutionarily conserved motif is required in cis for cell-type-restricted repression of the chicken alpha-smooth muscle actin gene core promoter.

1988 • 30 citations

A Combination of Closely Associated Positive and Negative cis-Acting Promoter Elements Regulates Transcription of the Skeletal α-Actin Gene

1990 • 20 citations

Growth Factors, Proto-oncogenes, And Plasticity Of The Cardiac Phenotype

1991 • 19 citations

Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.

1990 • 15 citations