Very Slow Turnover of β-Cells in Aged Adult Mice

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

2004 • 2,188 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

β-Cell death during progression to diabetes

2001 • 883 citations

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1996 • 700 citations

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

1999 • 693 citations

The biology of white adipocyte proliferation

2001 • 681 citations

A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development

1993 • 650 citations

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

2003 • 642 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

β cell replication is the primary mechanism for maintaining postnatal β cell mass

2004 • 488 citations

The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom

1986 • 453 citations

Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion

1989 • 447 citations

Gene regulatory factors in pancreatic development

2003 • 378 citations

Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

2005 • 328 citations

The pancreatic ductal epithelium serves as a potential pool of progenitor cells

2004 • 309 citations

Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes

2004 • 297 citations

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

2004 • 230 citations

Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy.

2000 • 221 citations

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

1993 • 191 citations

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

2003 • 183 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

2004 • 162 citations

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model

1995 • 162 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 152 citations

Effects of Aging on the Regenerative Capacity of the Pancreatic B-Cell of the Rat

1983 • 128 citations

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion

1989 • 104 citations

Quantification of Cell Turnover Kinetics Using 5-Bromo-2′-deoxyuridine1

2000 • 101 citations

Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass.

1994 • 62 citations

Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat

1983 • 61 citations

The life span of ganglionic glia in murine sensory ganglia estimated by uptake of bromodeoxyuridine

2004 • 16 citations