PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

2001 • 511 citations

A Mechanism for Nuclear Positioning in Fission Yeast Based on Microtubule Pushing

2001 • 486 citations

Drosophila Atypical Protein Kinase C Associates with Bazooka and Controls Polarity of Epithelia and Neuroblasts

2000 • 467 citations

Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo

1999 • 443 citations

Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans

2001 • 440 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

2000 • 405 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

1987 • 346 citations

A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila

2000 • 332 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Specification of the anteroposterior axis in Caenorhabditis elegans

1996 • 315 citations

Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System

2001 • 314 citations

Video Microscopy: The Fundamentals

1986 • 310 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

The Drosophila Homolog of C. elegans PAR-1 Organizes the Oocyte Cytoskeleton and Directs oskar mRNA Localization to the Posterior Pole

2000 • 291 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos

2001 • 262 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

PARsing Embryonic Polarity

2000 • 248 citations

CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 • 222 citations

Establishing cell polarity in development

2002 • 217 citations

Chapter 13 Blastomere Culture and Analysis

1995 • 151 citations

The Caenorhabditis elegans par-5 Gene Encodes a 14-3-3 Protein Required for Cellular Asymmetry in the Early Embryo

2002 • 150 citations

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.

1995 • 134 citations

Using RNA interference to identify genes required for RNA interference

2002 • 126 citations

LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues inC. elegansembryos

2002 • 107 citations

Fertilization and Establishment of Polarity in the Embryo

1997 • 98 citations

Microtubule dynamics in fish melanophores.

1994 • 76 citations

Microtubule assembly in clarifiedXenopus egg extracts

1997 • 53 citations