Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation

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1960 • 10,428 citations

Cardiovascular System

2000 • 2,962 citations

Wall stress and patterns of hypertrophy in the human left ventricle.

1975 • 2,343 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

1990 • 878 citations

Cardiac hypertrophy. Mechanical, neural, and endocrine dependence.

1991 • 625 citations

Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.

1990 • 607 citations

Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure

1967 • 505 citations

Role of Bradykinin in Mediating Vascular Effects of Angiotensin-Converting Enzyme Inhibitors in Humans

1997 • 332 citations

Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy

1995 • 309 citations

Serial Echocardiographic-Doppler Assessment of Left Ventricular Geometry and Function in Rats With Pressure-Overload Hypertrophy

1995 • 306 citations

Relation of left ventricular hemodynamic load and contractile performance to left ventricular mass in hypertension.

1990 • 244 citations

Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.

1994 • 240 citations

A specific B₂‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril

1992 • 236 citations

Angiotensin II Stimulation of Left Ventricular Hypertrophy in Adult Rat Heart

1992 • 207 citations

Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.

1994 • 196 citations

Bradykinin Antagonism Inhibits the Antigrowth Effect of Converting Enzyme Inhibition in the Dog Myocardium After Discrete Transmural Myocardial Necrosis

1995 • 164 citations

ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice

1994 • 159 citations

Cardiac angiotensinogen and its local activation in the isolated perfused beating heart.

1990 • 152 citations

Hemodynamic versus adrenergic control of cat right ventricular hypertrophy.

1985 • 146 citations

Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: a one year study in rats

1992 • 125 citations

Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis.

1994 • 123 citations

Mechanism for the Abnormal Energetics of Pressure-Induced Hypertrophy of Cat Myocardium

1973 • 123 citations

Identification and characterization of angiotensin II receptor subtypes in rabbit ventricular myocardium

1990 • 122 citations

Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart

1996 • 114 citations

Chronic progressive pressure overload of the cat right ventricle.

1981 • 110 citations

Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation

1995 • 102 citations

Angiotensin AT ₁ Receptor Inhibition

1997 • 94 citations

Differential Effects of Kinins on Cardiomyocyte Hypertrophy and Interstitial Collagen Matrix in the Surviving Myocardium After Myocardial Infarction in the Rat

1997 • 93 citations

Effect of angiotensin converting enzyme inhibition on pressure-induced left ventricular hypertrophy in rats.

1991 • 78 citations

Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor

1994 • 74 citations

Contribution of Local Renin-Angiotensin System to Cardiac Hypertrophy, Phenotypic Modulation, and Remodeling in TGR(mRen2)27 Transgenic Rats

1996 • 73 citations

Passive Load and Angiotensin II Evoke Differential Responses of Gene Expression and Protein Synthesis in Cardiac Myocytes

1996 • 70 citations

Load effects on gene expression during cardiac hypertrophy

1995 • 60 citations

Some Growth Factors Stimulate Cultured Adult Rabbit Ventricular Myocyte Hypertrophy in the Absence of Mechanical Loading

1995 • 57 citations

Protein metabolism of the heart

1984 • 53 citations

Load-Induced Growth Responses in Isolated Adult Rat Hearts

1997 • 44 citations

Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture

1996 • 40 citations

Role of Angiotensin in Pressure Overload-Induced Hypertrophy in Rats

1994 • 40 citations

Dose-Dependent Dissociation of ACE-Inhibitor Effects on Blood Pressure, Cardiac Hypertrophy, and β-Adrenergic Signal Transduction

1995 • 32 citations

Influence of Ramipril on Right Ventricular Hypertrophy Induced by Pulmonary Artery Stenosis in Rats

1990 • 26 citations

Activation of the Renin-Angiotensin System in Heart Failure and Hypertrophy--Studies in Human Hearts and Transgenic Rats

1994 • 18 citations

Downregulation of Angiotensin II Receptor Type 1 in Heart Failure

1997 • 18 citations

Effects of Losartan, an Angiotensin II Antagonist, on the Development of Cardiac Hypertrophy Due to Volume Overload.

1995 • 17 citations