Dominant-negative effect of the c-fos family gene products on inducible NO synthase expression in macrophages

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

AP-1 function and regulation

1997 • 2,833 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1995 • 532 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase

1998 • 339 citations

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1994 • 327 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

1994 • 207 citations

TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ

2000 • 204 citations

Central Role of Transcription Factor NF-IL6 for Cytokine and Iron-Mediated Regulation of Murine Inducible Nitric Oxide Synthase Expression

1999 • 173 citations

The Role of Nitric Oxide in Inflammation

1995 • 170 citations

Mitogen-activated Protein Kinases Mediate Activator Protein-1-dependent Human Inducible Nitric-oxide Synthase Promoter Activation

2001 • 167 citations

c-fos proto-oncogene regulation and function

1994 • 145 citations

Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line.

1989 • 122 citations

Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human Monocytes

1998 • 122 citations

Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

1998 • 117 citations

Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1.

1998 • 93 citations

A Physiologic Role of Bcl-xL Induced in Activated Macrophages

1998 • 76 citations

Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.

1998 • 66 citations

Prolonged Expression of c-fos Suppresses Cell Cycle Entry of Dormant Hematopoietic Stem Cells

1999 • 45 citations

CCAAT/ENHANCER BINDING PROTEIN IS INVOLVED IN THE EXPRESSION OF THE TUMOUR NECROSIS FACTOR GENE IN HUMAN MONOCYTES

1996 • 42 citations

c-Fos Induces Apoptosis in Germinal Center B Cells

1998 • 40 citations

Lineage-specific expression of c-fos and c-fms in human hematopoietic cells: Discrepancies with the in vitro differentiation of leukemia cells

1986 • 25 citations

Inducible expression of the proto-oncogene c-fos in transgenic mice.

1990 • 14 citations